A new ephrin-A1 isoform (ephrin-A1b) with altered receptor binding properties abrogates the cleavage of eptrin-A1a

Biochemical Journal

Volumn 379, Issue 1, 2004, Pages 39-46

  Finne, Eivind F ^a   Munthe, Else ^a   Aasheim, Hans Christian ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cleavage; Ephrin; Isoform; Phosphorylation; Receptor; Transfectant

Indexed keywords

AMINO ACIDS; ENZYME KINETICS; GLUCOSE; NEUROLOGY; PLASMAS; PROTEINS;

LIGANDS; RECEPTORS; TRANSFECTANTS;

BIOCHEMICAL ENGINEERING;

EPHRIN A1; EPHRIN A1A; EPHRIN A1B; EPHRIN RECEPTOR; EPHRIN RECEPTOR A2; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; EMBRYO; EXON; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA SPLICING;

AMINO ACID SEQUENCE; CELL LINE; DNA, COMPLEMENTARY; EPHRIN-A1; EXONS; GENES; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN ISOFORMS; RECEPTORS, EPH FAMILY; RECOMBINANT FUSION PROTEINS; RNA SPLICING; SIGNAL TRANSDUCTION; TONSIL; TRANSFECTION;

EID: 1842844303     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031619     Document Type: Article

References (29)

1. Cowan, C. A. and Henkemeyer, M. (2002) Ephrins in reverse, park and drive. Trends Cell Biol. 12, 339-346
2. Schmucker, D. and Zipursky, S. L. (2001) Signaling downstream of Eph receptors and ephrin ligands. Cell (Cambridge, Mass.) 105, 701-704
3. Flanagan, J. G. and van der Haeghen, P. (1998) The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 21, 309-345
4. Frisen, J., Holmberg, J. and Barbacid, M. (1999) Ephrins and their Eph receptors: multitalented directors of embryonic development. EMBO J. 18, 5159-5165
5. Holder, N. and Klein, R. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development 126, 2033-2044
6. Wilkinson, D. G. (2001) Multiple roles of EPH receptors and ephrins in neural development. Nat. Rev. Neurosci. 2, 155-164
7. Murai, K. K. and Pasquale, E. B. (2003) 'Eph'ective signaling: forward, reverse and crosstalk. J. Cell Sci. 116, 2823-2832
8. Gale, N. W., Holland, S. J., Valenzuela, D. M., Flenniken, A., Pan, L., Ryan, T. E., Henkemeyer, M., Strebhardt, K., Hirai, H., Wilkinson, D. G. et al. (1996) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17, 9-19
9. Sakano, S., Serizawa, R., Inada, T., Iwama, A., Itoh, A., Kato, C., Shimizu, Y., Shinkai, F., Shimizu, R., Kondo, S. et al. (1996) Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells. Oncogene 13, 813-822
10. Brambilla, R., Schnapp, A., Casagranda, F., Labrador, J. P., Bergemann, A. D., Flanagan, J. G., Pasquale, E. B. and Klein, R. (1995) Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J. 14, 3116-3126
11. Cowan, C. A. and Henkemeyer, M. (2001) The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature (London) 413, 174-179
12. Palmer, A., Zimmer, M., Erdmann, K. S., Eulenburg, V., Porthin, A., Heumann, R., Deutsch, U. and Klein, R. (2002) EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol. Cell 9, 725-737
13. Davy, A., Gale, N. W., Murray, E. W., Klinghoffer, R. A., Soriano, P., Feuerstein, C. and Robbins, S. M. (1999) Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev. 13, 3125-3135
14. Huai, J. and Drescher, U. (2001) An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. J. Biol. Chem. 276, 6689-6694
15. Hattori, M., Osterfield, M. and Flanagan, J. G. (2000) Regulated cleavage of a contact mediated axon repellent. Science 289, 1360-1365
16. Aasheim, H. C., Terstappen, L. W. and Logtenberg, T. (1997) Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis. Blood 90, 3613-3622
17. Aasheim, H. C., Munthe, E., Funderud, S., Smeland, E. B., Beiske, K. and Logtenberg, T. (2000) A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. Blood 95, 221-230
18. Munthe, E., Rian, E., Holien, T., Rasmussen, A., Levy, F. O. and Aasheim, H. C. (2000) Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. FEBS Lett. 466, 169-174
19. Wabakken, T., Hauge, H., Funderud, S. and Aasheim, H. C. (2002) Characterization, expression and functional aspects of a novel protein tyrosine phosphatase ε isoform. Scand. J. Immunol. 56, 276-285
20. Holzman, L. B., Marks, R. M. and Dixit, V. M. (1990) A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol. Cell. Biol. 10, 5830-5838
21. Bartley, T. D., Hunt, R. W., Welcher, A. A., Boyle, W. J., Parker, V. P., Lindberg, R. A., Lu, H. S., Colombero, A. M., Elliott, R. L., Guthrie, B. A. et al. (1994) B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature (London) 368, 558-560
22. Himanen, J. P., Rajashankar, K. R., Lackmann, M., Cowan, C. A., Henkemeyer, M. and Nikolov, D. B. (2001 ) Crystal structure of an Eph receptor-ephrin complex. Nature (London) 414, 933-938
23. Toth, J., Cutforth, T., Gelinas, A. D., Bethoney, K. A., Bard, J. and Harrison, C. J. (2001) Crystal structure of an ephrin ectodomain. Dev. Cell 1, 83-92
24. Menzel, P., Valencia, F., Godement, P., Dodelet, V. C. and Pasquale, E. B. (2001) Ephrin-A6, a new ligand for EphA receptors in the developing visual system. Dev. Biol. 230, 74-88
25. Flenniken, A. M., Gale, N. W., Yancopoulos, G. D. and Wilkinson, D. G. (1996) Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev. Biol. 179, 382-401
26. Li, Y. Y., Mi, Z., Feng, Y., McTiernan, C. F., Zhou, R., Robbins, P. D., Watkins, S. C. and Feldman, A. M. (2001) Differential effects of overexpression of two forms of ephrin-A5 on neonatal rat cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 281, H2738-H2746
27. Lai, K. O., Ip, F. C. and Ip, N. Y. (1999) Identification and characterization of splice variants of ephrin-A3 and ephrin-A5. FEBS Lett. 458, 265-269
28. Bergemann, A. D., Cheng, H. J., Brambilla, R., Klein, R. and Flanagan, J. G. (1995) ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol. Cell. Biol. 15, 4921-4929
29. Davy, A. and Robbins, S. M. (2000) Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner. EMBO J. 19, 5396-5405