Theme 9. Genotypic resistance tests for the management of the patient failing highly active antiretroviral therapy: The resistance pattern in different biological compartments

Scandinavian Journal of Infectious Diseases, Supplement

Volumn , Issue 106, 2003, Pages 90-93

  Liuzzi, Giuseppina ^a  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; LAMIVUDINE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; VIRUS RNA; ZIDOVUDINE;

ARTICLE; ASSAY; BODY FLUID; DRUG BLOOD LEVEL; DRUG SENSITIVITY; DRUG TISSUE LEVEL; FEMALE; GENETIC VARIABILITY; GENOTYPE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MALE GENITAL SYSTEM; MEDICAL DECISION MAKING; POPULATION RESEARCH; PRACTICE GUIDELINE; RISK BENEFIT ANALYSIS; SEXUAL TRANSMISSION; SPERM; STRAIN DIFFERENCE; TREATMENT FAILURE; TREATMENT OUTCOME; VIREMIA; VIRUS INHIBITION; VIRUS ISOLATION; VIRUS LOAD; VIRUS REPLICATION; ANTIBIOTIC RESISTANCE; DRUG EFFECT; FOLLOW UP; GENETICS; HOSPITALIZATION; HUMAN IMMUNODEFICIENCY VIRUS 1; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; REVIEW; RISK ASSESSMENT; VIROLOGY;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DRUG RESISTANCE, VIRAL; FOLLOW-UP STUDIES; GENITALIA, MALE; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; RISK ASSESSMENT; RNA, VIRAL; SEVERITY OF ILLNESS INDEX; TREATMENT FAILURE; VIRAL LOAD; VIRUS REPLICATION;

EID: 1842830220     PISSN: 03008878     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Baxter JD, Mayers DL, Wentworth DN, Neaton JD, Hoover ML, Winters MA, et al. A randomised study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. AIDS 2000; 14: F83-4.
2. Durant J, Clevenbergh P, Halfon P, Delgiudice P, Porsin S, Simonet P, et al. Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial. Lancet 1999; 353: 2195-9.
3. Kroodsma KL, Kozal MJ, Hamed KA, Winters MA, Merigan TC. Detection of drug resistance mutations in the human immunodeficiency virus type 1 pol gene: differences in semen and blood HIV-1 RNA and proviral DNA. J Infect Dis 1994; 170: 1292-5.
4. Di Stefano M, Sabri F, Leitner T, Svennerholm B, Hagberg L, Norkrans G, Chiodi F. Reverse transcriptase sequence of paired isolates of cerebrospinal fluid and blood from patients infected with human immunodeficiency virus type 1 during zidovudine treatment. J Clin Microbiol 1995; 33: 352-5.
5. Gunthard HF, Wong JK, Ignacio CC, Guatelli JC, Riggs NL, Havlir DV, Richman DD. Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy. J Virol 1998; 72: 2422-8.
6. Venturi G, Catucci M, Romano L, Corsi P, Leoncini F, Valensin PE, Zazzi M. Antiretroviral resistance mutations in human immunodeficiency virus type 1 reverse transcriptase and protease from paired cerebrospinal fluid and plasma samples. J Infect Dis 2000; 181: 740-5.
7. Royce RA, Sena A, Cates Jr W, Cohen MS. Sexual transmission of HIV. N Engl J Med 1997; 336: 1072-8.
8. Vernazza PL, Eron JJ, Cohen MS, van der Horst CM, Troiani L, Fiscus SA. Detection and biologic characterisation of infectious HIV-1 in semen of seropositive men. AIDS 1994; 8: 1325-9.
9. Liuzzi G, Chirianni A, Clementi M, Bagnarelli P, Valenza A, Tullio Cataldo P, Piazza M. Analysis of HIV-1 load in blood, semen and saliva: evidence for different viral compartments in a cross-sectional and longitudinal study. AIDS 1996; 10: F51-6.
10. Zhu T, Wang N, Carr A, Nam DS, Moor-Jankowski R, Cooper DA, Ho DD. Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J Virol 1996; 70: 3098-107.
11. Liuzzi G, Chirianni A, Bagnarelli P, Clementi M, Piazza M. A combination of nucleoside analogues and a protease inhibitor reduces HIV-1 RNA levels in semen: implications for sexual transmission of HIV infection. Antivir Ther 4(year?): 95-9.
12. Vernazza PL, Troiani L, Flepp MJ, Cone RW, Schock J, Roth F, et al. Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. AIDS 2000; 14: 117-21.
13. Richman D. Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents. Antimicrob Agents Chemother 1993; 37: 1207-13.
14. Condra JH, Schleif WA, Blahy OM, Gabryelski LJ, Graham DJ, Quintero JC, et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995; 374: 569-71.
15. Eron JJ, Vernazza PL, Johnston DM, Seillier-Moiseiwitsch F, Alcorn TM, Fiscus SA, Cohen MS. Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: implications for transmission. AIDS 1998; 12: F181-9.
16. Little SJ, Daar ES, D'Aquila RT, Keiser PH, Connick E, Whitcomb JM, et al. Reduced antiretroviral drug susceptibility among patients with primary HIV infection. JAMA 1999; 282: 1142-9.
17. Brodine SK, Shaffer RA, Starkey MJ, Tasker SA, Gilcrest JL, Louder MK, et al. Drug resistance patterns, genetic subtypes, clinical features, and risk factors in military personnel with HIV-1 seroconversion. Ann Intern Med 1999; 131: 502-6.
18. Mayer KH, Boswell S, Goldstein R, Lo W, Xu C, Tucker L, et al. Persistence of human immunodeficiency virus in semen after adding indinavir to combination antiretroviral therapy. Clin Infect Dis 1999; 28: 1252-9.
19. Byrn R, Zhang D, Eyre R, McGowan K, Kiessling AA. HIV-1 in semen: an isolated virus reservoir. Lancet 1997; 350: 1141.
20. DePaquale MP, Kartsonia N, Martinez-Picado J, Eron J, Fiscus S, Schok J, et al. Selection of protease resistance mutations in semen. Program and Abstracts of the 6th Conference on Retroviruses and Opportunistic Infections, Chicago, USA, 31 January-4 February 1999. Abstract 11.
21. Kashuba A, Dyer J, Kramer L, Raasch R, Eron J, Cohen M. Antiretroviral drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1. Antimicrob Agents Chemother 1999; 43: 1817-26.
22. van Praag RM, Weverling GJ, Portegies P, Jurriaans S, Zhou XJ, Turner-Foisy ML, et al. Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir. AIDS 2000; 14: 1187-94.
23. Pereira A, Eron J, Dunn J, Gerber J, Tidwell R, Kenney K, et al. Analysis of amprenavir (APV)/3TC/ZDV in blood and seminal plasma: penetration of APV into the male genital tract. Program and Abstracts of the 7th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, 30 January-2 February 2000. Abstract 317.
24. Clinical and laboratory guidelines for the use of HIV-1 drug resistance testing as part of treatment management recommendations for the European setting. AIDS 2001; 15: 309-20.
25. Wainberg MA, Friedland G. Public health implications of antiretroviral therapy and HIV drug resistance. JAMA 1999; 279: 1984-91.
26. Yerly S, Kaiser L, Race E, Bru J-P, Clavel F, Perrin L. Transmission of antiretroviral-drug-resistant HIV-1 variants. Lancet 1999; 354: 729-33.
27. Boden D, Hurley A, Zhang L, Cao Y, Guo Y, Jones E, et al. HIV-1 drug resistance in newly infected individuals. JAMA 1999; 282: 1135-41.
28. Pereira A., Kashuba A., Fiseus S, et al. Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentrations and viral burden. J Infect Dis 1999; 180: 2039-2043.
29. Liuzzi G, Chirianni A, Casazza R, Tallarino A, Piazza M. Concentration of stavudine in blood and semen from HIV-1 infected patients. 5th International Congress on Drug Therapy in HIV Infection, Glasgow, UK, 22 26 October 2000. p. 279. AIDS 2000; 14 (Suppl 4): S96.
30. Gupta P, Mellors J, Kingsley L, Riddler S, Singh MK, Schreiber S, et al. High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors. J Virol 1997; 71: 6271-5.
31. Hecht FM, Grant RM, Petropoulos CJ, Dillon B, Chesney MA, Tian H, et al. Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors. N Engl J Med 1998; 339: 307-11.
32. Imrie A, Beveridge A, Genn W, Vizzard J, Cooper DA. Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine. Sydney Primary HIV Infection Study Group. J Infect Dis 1997; 175: 1502-6.
33. Cohen MS, Hoffman IF, Royce RA, Kazembe P, Dyer JR, Daly CC, et al. Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSAP Malawi Research Group. Lancet 1997; 349: 1868-73.