Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess

Osteoarthritis and Cartilage

Volumn 12, Issue 4, 2004, Pages 321-335

  Johnson, K ^a   Terkeltaub, R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chondrocalcinosis; CPPD; NPP1; PC 1; TGF

Indexed keywords

BASIC CALCIUM PHOSPHATE CYRSTAL DEPOSITION INHIBITOR; COLLAGEN; COLLAGENASE 3; INHIBITOR PROTEIN; MEMBRANE PROTEIN; NUCLEOTIDE PYROPHOSPHATASE; PHOSPHODIESTERASE; PROTEIN ANK; PROTEIN PPI; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CALCIFICATION; CARTILAGE CELL; CELL GROWTH; CHONDROCALCINOSIS; CHROMOSOME 5P; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; EXTRACELLULAR SPACE; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNOCKOUT GENE; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PROTEOGLYCAN SYNTHESIS; UPREGULATION; WILD TYPE;

EID: 1842788532     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2003.12.004     Document Type: Article

References (40)

1. Terkeltaub RA. What does cartilage calcification tell us about osteoarthritis? J Rheumatol 2002;29:411-5.
2. Silcox DC, McCarty DJ. Jr. Elevated inorganic pyrophosphate concentrations in synovial fluids in osteoarthritis and pseudogout. J Lab Clin Med 1974; 83:518-31.
3. Johnson K, Hashimoto S, Lotz M, Pritzker K, Goding J, Terkeltaub R. Upregulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification. Arthritis Rheum 2001;44:1071-81.
4. Rosen F, McCabe G, Quach J, Solan J, Terkeltaub R, Seegmiller JE. Differential effects of aging on human chondrocyte responses to transforming growth factor beta: Increased pyrophosphate production and decreased cell proliferation. Arthritis Rheum 1997; 40:1275-81.
5. Doherty M, Chuck A, Hosking D, Hamilton E. Inorganic pyrophosphate in metabolic diseases predisposing to calcium pyrophosphate dihydrate crystal deposition. Arthritis Rheum 1991;34:1297-303.
6. Rosenthal AK, Ryan LM. Ageing increases growth factor-induced inorganic pyrophosphate elaboration by articular cartilage. Mech Ageing Dev 1994; 75:35-44.
7. Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 2001;281:C1-11.
8. Johnson K, Hashimoto S, Lotz M, Pritzker K, Terkelatub R. IL-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa. Am J Pathol 2001;159:149-63.
9. Johnson K, Vaingankar S, Chen Y, Moffa A, Goldring MB, Mary B, et al. Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Arthritis Rheum 1999;42:1986-97.
10. Johnson KA, Hessle L, Vaingankar S, Wennberg C, Mauro S, Narisawa S. Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. Am J Physiol Regul Integr Comp Physiol 2000; 279:R1365-77.
11. Rutsch F, Vaingankar S, Johnson K, Goldfine I, Maddux B, Schauerte P, et al. PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol 2001;158:543-54.
12. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, et al. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA 2002; 99:9445-9.
13. Ho A, Johnson M, Kingsley DM. Role of the mouse ank gene in tissue calcification and arthritis. Science 2000;289:265-70.
14. Nurnberg P, Thiele H, Chandler D, Höhne W, Cunningham ML, Ritter H, et al. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nat Genet 2001;28:37-41.
15. Pendleton A, Johnson MD, Hughes A, Gurley KA, Ho AM, Doherty M. Mutations in ANKH cause chondrocalcinosis. Am J Hum Genet 2002;71: 933-40.
16. Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 1998;19:271-3.
17. Williams CJ, Zhang Y, Timms A, Bonavita G, Caeiro F, Broxholme J, et al. Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH. Am J Hum Genet 2002;71:985-91.
18. Lotz M, Rosen F, McCabe G, Quach J, Blanco F, Dudler J, et al. Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes. Proc Natl Acad Sci USA 1995;92: 10364-8.
19. Hirose J, Ryan LM, Masuda I. Upregulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease. Arthritis Rheum 2002;46:3218-29.
20. i and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. Am J Bone Min Res 2003;18:994-1004.
21. Johnson K, Farley D, Hu S-I, Terkeltaub R. One of two chondrocyte-expressed isoforms of Cartilage Intermediate Layer Protein functions as an IGF-I antagonist. Arthritis Rheum 2003;48:1302-14.
22. Johnson K, Jung AS, Andreyev A, Murphy A, Dykens J, Terkeltaub R. Mitochondrial Oxidative Phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis Rheum 2000;43:1560-70.
23. Wu CW, Tchetina EV, Mwale F. Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization. J Bone Miner Res 2002;17:639-51.
24. Wu W, Billinghurst RC, Pidoux I. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum 2002;46:2087-94.
25. Ryan LM, Rachow JW, McCarty DJ. Synovial fluid ATP: A potential substrate for the production of inorganic pyrophosphate. J Rheumatol 1991;18:716-20.
26. Ryan LM, Kurup IV, Derfus BA, Kushnaryov VM. ATP-induced chondrocalcinosis. Arthritis Rheum 1992;35:1520-5.
27. Ryan LM, Wortmann RL, Karas B, McCarty DJ. Jr. Cartilage nucleoside triphosphate (NTP) pyrophosphohydrolase. Identification as an ecto-enzyme. Arthritis Rheum 1984;27:404-9.
28. Ryan LM, McCarty DJ. Understanding inorganic pyrophosphate metabolism: Toward prevention of calcium pyrophosphate dihydrate crystal deposition. Ann Rheum Dis 1995;54:939-41.
29. Rosenthal AK, Ryan LM. Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes. J Rheumatol 1994;21: 896-900.
30. Scharstuhl A, Glansbeek HL, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB. Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. J Immunol 2002; 169:507-14.
31. Rosenthal AK, Cheung HS, Ryan LM. Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. Arthritis Rheum 1991;34:904-11.
32. Johnson K, Moffa A, Chen Y, Pritzker K, Goding J, Terkeltaub R. Matrix vesicle plasma cell membrane glycoprotein-1 regulates mineralization by murine osteoblastic MC3T3 cells. J Bone Miner Res 1999; 14:883-92.
33. Bello V, Goding JW, Greengrass V, Sali A, Dubljevic V, Lenoir C, et al. Characterization of a di-leucine-based signal in the cytoplasmic tail of the nucleotide-pyrophosphatase NPP1 that mediates basolateral targeting but not endocytosis. Mol Biol Cell 2001; 12:3004-15.
34. Belli SI, van Driel IR, Goding JW. Identification and characterization of a soluble form of the plasma cell membrane glycoprotein PC-1 (5′-nucleotide phosphodiesterase). Eur J Biochem 1993;217: 421-8.
35. Squires GR, Okouneff S, Ionescu M, Poole AR. The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum 2003;48:1261-70.
36. Wei L, Svensson O, Hjerpe A. Proteoglycan turnover during development of spontaneous osteoarthrosis in guinea pigs. Osteoarthritis Cart 1998;6:410-6.
37. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, et al. S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death. Science 2002; 297:1186-90.
38. Jaovisidha K, Rosenthal AK. Calcium crystals in osteoarthritis. Curr Opin Rheumatol 2002;14: 298-302.
39. Ledingham J, Regan M, Jones A, Doherty M. Factors affecting radiographic progression of knee osteoarthritis. Ann Rheum Dis 1995;54:53-8.
40. Doherty M, Dieppe P, Watt I. Pyrophosphate arthropathy: A prospective study. Br J Rheumatol 1993; 32:189-96.