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1
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1842645940
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The mechanism of these reactions involves O-protonation (coordination to a Lewis acid) of β-phenethylamides followed by electrophilic aromatic cyclialkylation. See: Olah G.A. New York: Interscience
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The mechanism of these reactions involves O-protonation (coordination to a Lewis acid) of β-phenethylamides followed by electrophilic aromatic cyclialkylation. See: Barclay L.R.C. Olah G.A. Friedel-Crafts and Related Reactions. Vol. 2, Part 2:1964;873-937 Interscience, New York.
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(1964)
Friedel-Crafts and Related Reactions
, vol.22
, pp. 873-937
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Barclay, L.R.C.1
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3
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0037073928
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See, for example:
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See, for example: Koltunov K.Yu., Prakash G.K.S., Rasul G., Olah G.A. J. Org. Chem. 67:2002;8943-8951.
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(2002)
J. Org. Chem.
, vol.67
, pp. 8943-8951
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Koltunov, K.Yu.1
Prakash, G.K.S.2
Rasul, G.3
Olah, G.A.4
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6
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0037872105
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and references cited therein
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Zhang Y., McElrea A., Sanchez G.V., Do D., Gomez A., Aguirre S.L., Rendy R., Klumpp D.A. J. Org. Chem. 68:2003;5119-5122. and references cited therein.
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(2003)
J. Org. Chem.
, vol.68
, pp. 5119-5122
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Zhang, Y.1
McElrea, A.2
Sanchez, G.V.3
Do, D.4
Gomez, A.5
Aguirre, S.L.6
Rendy, R.7
Klumpp, D.A.8
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7
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0000265739
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G.A. Olah, Schleyer P.R. New York: Wiley-Interscience
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Olah G.A., White A.M., O'Brien D.H. Olah G.A., Schleyer P.R. Carbonium Ions. Vol. 4:1973;1697-1781 Wiley-Interscience, New York.
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(1973)
Carbonium Ions
, vol.4
, pp. 1697-1781
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Olah, G.A.1
White, A.M.2
O'Brien, D.H.3
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9
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0034893029
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and references cited therein
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Bagno A., Kantlehner W., Scherr O., Vetter J., Ziegler G. Eur. J. Org. Chem. 16:2001;2947-2954. and references cited therein.
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(2001)
Eur. J. Org. Chem.
, vol.16
, pp. 2947-2954
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Bagno, A.1
Kantlehner, W.2
Scherr, O.3
Vetter, J.4
Ziegler, G.5
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12
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0345735265
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and references cited therein
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Johnston K.M. Tetrahedron. 24:1968;5595-5598. and references cited therein.
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(1968)
Tetrahedron
, vol.24
, pp. 5595-5598
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Johnston, K.M.1
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16
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0034704819
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β-Arylcarboxylic acids (acid chlorides) have mostly been prepared by different ways as precursors and subsequently worked up with ammonia or amines. Another approach includes nucleophilic 1,4-addition of arylsiloxanes or Grignard reagents to α,β-unsaturated amides. See, for example:
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β-Arylcarboxylic acids (acid chlorides) have mostly been prepared by different ways as precursors and subsequently worked up with ammonia or amines. Another approach includes nucleophilic 1,4-addition of arylsiloxanes or Grignard reagents to α,β-unsaturated amides. See, for example: Elz S., Kramer K., Pertz H.H., Detert H., Laak A.M., Kuhne R., Schunack W. J. Med. Chem. 43:2000;1071-1084.
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(2000)
J. Med. Chem.
, vol.43
, pp. 1071-1084
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Elz, S.1
Kramer, K.2
Pertz, H.H.3
Detert, H.4
Laak, A.M.5
Kuhne, R.6
Schunack, W.7
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17
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0034727852
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Froimowitz M., Wu K.-M., Moussa A., Haidar R.M., Jurayj J., George C., Dardner E.L. J. Med. Chem. 43:2000;4981-4992.
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(2000)
J. Med. Chem.
, vol.43
, pp. 4981-4992
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Froimowitz, M.1
Wu, K.-M.2
Moussa, A.3
Haidar, R.M.4
Jurayj, J.5
George, C.6
Dardner, E.L.7
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19
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1842696299
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U.S. Patent 5196607, 1993
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Quallich, G. J. U.S. Patent 5196607, 1993.
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Quallich, G.J.1
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20
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1842696295
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note
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4 and concentrated in vacuo to give 6 as pure individual compound.
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24
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1842746664
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note
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13C NMR δ 35.7, 62.2, 118.7, 127, 136.3, 136.3, 143.2, 158.1, 177.2, 188.7. Quenching this acidic solution with ice provided back the starting material.
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28
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1842797168
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Ref. 12, pp 295-298, 332-335
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(a) Ref. 12, pp 295-298, 332-335.
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