Target driven chemistry in drug discovery

Drug Discovery Today

Volumn 9, Issue 8, 2004, Pages 348-349

  Eliseev, Alexey V ^a  

^a Alantos Pharmaceuticals Inc   (United States)

Author keywords

Drug Discovery; HTS; Pharmaceutical Science; Small molecule inhibitors; Target driven chemistry; Techniques Methods

Indexed keywords

NEW DRUG;

CATALYSIS; CHEMICAL COMPOSITION; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CHEMISTRY; CYCLOADDITION; DRUG RESEARCH; DRUG SYNTHESIS; REACTION ANALYSIS; SHORT SURVEY; SYNTHESIS;

EID: 1842635467     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(04)03026-0     Document Type: Note

References (7)

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2. Ramstrom O., Lehn J.M. Drug discovery by dynamic combinatorial libraries. Nature Rev. Drug Discov. 1:2002;26-36.
3. Nguyen R., Huc I. Using an enzyme's active site to template inhibitors. Angew. Chem. Int. Ed. 40:2001;1774-1776.
4. Yu Y.H., et al. Formation of a class of enzyme inhibitors (drugs), including a chiral compound, by using imprinted polymers or biomolecules as molecular-scale reaction vessels. Angew. Chem. Int. Ed. 41:2002;4459-4463.
5. Lewis W.G., et al. Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angew. Chem. Int. Ed. 41:2002;1053-1057.
6. Nicolaou K.C., et al. Target-accelerated combinatorial synthesis and discovery of highly potent antibiotics effective against vancomycin-resistant bacteria. Angew. Chem. Int. Ed. 39:2000;3823-3828.
7. Jencks W.P. Catalysis in Chemistry and Enzymology. 1969;McGrow Hill.