Age effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats

Brazilian Journal of Medical and Biological Research

Volumn 37, Issue 3, 2004, Pages 385-390

  Nunan, E A ^a   Arya, V ^b   Hochhaus, G ^b   Cardoso, V N ^a   Moraes Santos, T ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Age; Bootstrapping resampling; Non compartmental analysis; Pharmacokinetics; Scorpion venom; Tityustoxin

Indexed keywords

SCORPION VENOM; TECHNETIUM 99M; TITYUS TOXIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DATA ANALYSIS; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; GROUPS BY AGE; MALE; NONHUMAN; RAT; TIME; TISSUE DISTRIBUTION; TOXICOKINETICS;

ANIMALIA; SCORPIONES; TITYUS; TITYUS SERRULATUS;

EID: 1842607625     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2004000300016     Document Type: Article

References (32)

1. Sampaio SV, Laure CJ & Giglio JR (1983). Isolation and characterization of toxic proteins from the venom of the Brazilian scorpion Tityus serrulatus. Toxicon, 21: 265-277.
2. Bucaretchi F, Bacarat ECE, Nogueira RJN, Chave A, Zambrone FAD, Fonseca MRCC & Tourinho FS (1995). A comparative study of severe scorpion envenomation in children caused by Tityus bahiensis and Tityus serrulatus. Revista do Instituto de Medicina Tropical de São Paulo, 37: 331-336.
3. Kalapothakis E & Chávez-Olórtegui C (1997). Venom variability among several Tityus serrulatus specimens. Toxicon, 35: 1523-1529.
4. Massensini AR, Suckling J, Brammer MJ, Moraes-Santos T, Gomez MV & Romano-Silva MA (2002). Tracking sodium channels in live cells: confocal imaging using fluorescently labeled toxins. Journal of Neuroscience Methods, 116: 189-196.
5. 2+-channels. Cellular and Molecular Neurobiology, 22: 819-826.
6. 3H] aminobutyric acid in rat brain cortical slices by α-scorpion toxin. Neuroscience Letters, 325: 155-158.
7. Sofer S & Gueron M (1988). Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: hemodynamic and neurological aspects. Toxicon, 26: 931-939.
8. Amaral CFS, Rezende NA & Freire-Maia L (1993). Acute pulmonary edema after Tityus serrulatus scorpion sting in children. American Journal of Cardiology, 71: 242-245.
9. Mesquita MBS, Moraes-Santos T & Moraes MFD (2002). Phenobarbital blocks the lung edema induced by centrally injected tityustoxin in adult Wistar rats. Neuroscience Letters, 332: 119-122.
10. Ismail M & Abd-Elsalam A (1988). Are the toxicological effects of scorpion envenomation related to tissue venom concentration? Toxicon, 26: 233-236.
11. Ismail M, Abd-Elsalam A & Morad AM (1990). Do changes in body temperature following envenomation by the scorpion Leiurus quinquestriatus influence the course of toxicity? Toxicon, 28: 1265-1284.
12. Magalhães MM, Garbacio VL, Almeida MB, Braz ACA, Moraes-Santos T, Freire-Maia L & Cunha-Melo JR (2000). Acid-base balance following Tityus serrulatus scorpion envenoming in anaesthetized rats. Toxicon, 38: 855-864.
13. Cupo P, Jurca M, Azevedo-Marques MM, Oliveira MJS & Hering SE (1994). Severe scorpion envenomation in Brazil. Clinical, laboratory and anatomopathological aspects. Revista do Instituto de Medicina Tropical de São Paulo, 36: 67-76.
14. Amitai Y, Mines Y, Aker M & Goitein K (1985). Scorpion sting in children. Clinical Pediatrics, 24: 136-139.
15. Clot-Faybesse O, Guieu R, Rochat H & Devaux C (2000). Toxicity during early development of the mouse nervous system of a scorpion neurotoxin active on sodium channels. Life Sciences, 66: 185-192.
16. Nunan EA, Cardoso VN & Moraes-Santos T (2001). Lethal effect of the scorpion Tityus serrulatus venom: Comparative study on adult and weanling rats. Brazilian Journal of Pharmaceutical Sciences, 37: 39-44.
17. Magalhães O (1938). Scorpionism. Journal of Tropical Medicine and Hygiene, 41: 393-399.
18. Freire-Maia L, Pinto GI & Franco I (1974). Mechanism of the cardiovascular effects produced by purified scorpion toxin in the rat. Journal of Pharmacology and Experimental Therapeutics, 188: 207-213.
19. Drumond YA, Couto AS, Moraes-Samos T, Almeida AP & Freire-Maia L (1995). Effects of toxin Ts-γ and tityustoxin purified from Tityus serrulatus venom on isolated rat atria. Comparative Biochemistry and Physiology, 111C: 183-190.
20. 125I-labelled venom from the scorpion Androctonus amoreuxi, Aud. and Sav. Toxicon, 18: 301-308.
21. Ismail M, Amal J, Fatani Y & Da Bees TT (1992). Experimental treatment protocols for scorpion envenomation: A review of common therapies and effect of kallikrein-kinin inhibitors. Toxicon, 30: 1257-1279.
22. Ismail M, Abd-Elsalam A & Al-Ahaidib MS (1994). Androctonus crassicauda (Olivier), a dangerous and unduly neglected scorpion. I. Pharmacological and clinical studies. Toxicon, 32: 1599-1618.
23. Santana GC, Freire ACT, Ferreira APL, Chávez-Olórtegui C, Diniz CR & Freire-Maia L (1996). Pharmacokinetics of Tityus serrulatus scorpion venom determined by enzyme-linked immunosorbent assay in the rat. Toxicon, 34: 1063-1066.
24. Calderón-Aranda ES, Rivière G, Choumet V, Possani LD & Bom C (1999). Pharmacokinetics of toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab′) 2. Toxicon, 37: 771-782.
25. Nunan EA, Cardoso VN & Moraes-Santos T (2002). Technetium-99m labeling of tityustoxin and venom from scorpion Tityus serrulatus. Applied Radiation and Isotopes, 57: 849-852.
26. United States Pharmacopoeia (1995). 23rd edn. United States Pharmacopeial Convention, Inc., Rockville, MD, USA, 1312-1313.
27. Iwi GRKM, Palmer AM, Preece AW & Saunders M (1999). Bootstrap resampling: A powerful method of assessing confidence intervals for doses for experimental data. Physics in Medicine and Biology, 44: N55-N62.
28. Mager HGG (1998). Resampling methods in sparse sampling situations in pre-clinical pharmacokinetic studies. Journal of Pharmaceutical Sciences, 87: 372-378.
29. Nunan EA, Moraes MFD, Cardoso VN & Moraes-Santos T (2003). Effect of age on body distribution of tityustoxin from Tityus serrulatus scorpion venom in rats. Life Sciences, 73: 319-325.
30. Rowland M & Tozer TN (1995). Clinical Pharmacokinetics - Concepts and Applications. 3rd edn. Lea & Febriger, London, UK.
31. 125I-labelled antivenom to the venom from scorpion Androctonus amoreuxi. Toxicon, 21: 47-56.
32. 2 and fractions of scorpion and snake antivenins: Merits and potential for therapeutic use. Toxicon, 36: 1523-1528.