Technetium-99m labeling of tityustoxin and venom from the scorpion Tityus serrulatus

Applied Radiation and Isotopes

Volumn 57, Issue 6, 2002, Pages 849-852

  Nunan, E A ^a   Cardoso, V N ^a   Moraes Santos, T ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Labeling; LD50; Scorpion venom; Technetium 99m; Tityustoxin

Indexed keywords

CHROMATOGRAPHY; NEUROLOGY; SODIUM COMPOUNDS;

TOXIC FRACTION;

TECHNETIUM;

SCORPION VENOM; SEPHADEX; SODIUM BOROHYDRIDE; STANNOUS CHLORIDE; TECHNETIUM 99M; TITYUS TOXIN;

ARTICLE; CHROMATOGRAPHY; DRUG ACTIVITY; ISOTOPE LABELING; NEUROCHEMISTRY; NEUROPHARMACOLOGY; PRIORITY JOURNAL; RADIATION DOSE; SCORPION;

ANIMALS; ORGANOTECHNETIUM COMPOUNDS; SCORPION VENOMS; SCORPIONS;

EID: 0036888713     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(02)00197-5     Document Type: Article

References (17)

1. + channel J. Biol. Chem. 257(21):1982;12553-12558.
2. Catterall W.A. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Ann. Rev. Pharmacol. Toxicol. 20:1980;15-43.
3. Chan P.K., O'Hara G.P., Hayes A.W. Principles and methods for acute and sub chronic toxicity. Hayers W. Principle and Methods of Toxicology. 1992;1-51 Ravens Press, New York.
4. 99mTc labeled radiopharmaceuticals. Semin. Nucl. Med. 20:1990;5-27.
5. 99mTechnetium labelled Escherichia coli. Appl. Radiat. Isotopes. 51:1999;33-36.
6. Finney, D.J., 1978. Statistical Method in Biological Assay, 3rd Ed. Charles Griffin, London, pp. 349-369.
7. Gomez M.V., Diniz C.R. Separation of toxic components from Brazilian scorpion - Tityus serrulatus venom. Mem. Inst. Butantan Simp. Internac. 3:1966;899-902.
8. Hartree E.F. Determination of protein. a modification of the Lowry method that gives a linear photometric response Anal. Biochem. 48:1972;422-427.
9. 2 fraction from scorpion (Tityus serrulatus, Lutz and Mello) venom by iodination and some immunogenic properties of the derivatives. Toxicon. 24:1986;501-505.
10. Ismail M. The scorpion envenoming syndrome. Toxicon. 33:1995;825-858.
11. Ismail M., Abd-Elsalam A. Are the toxicological effects of scorpion envenomation related to tissue venom concentration? Toxicon. 26:1988;233-236.
12. Ismail M., Abd-Elsalam A., Al-Ahaidib M.S. Androctonus crassicauda (Olivier), a dangerous and unduly neglected scorpion - I. Pharmacological and clinical studies. Toxicon. 32:1994;1599-1618.
13. Kalapothakis E., Chávez-Olórtegui C. Venom variability among several Tityus serrulatus specimens. Toxicon. 35(10):1997;1523-1529.
14. 4 and stannous chloride Nucl. Med. Biol. 20(7):1993;825-833.
15. Sampaio S.V., Laure C.J., Giglio J.R. Isolation and characterization of toxic proteins from the venom of the Brazilian scorpion Tityus serrulatus. Toxicon. 21:1983;265-277.
16. United States Pharmacopéia, 1995. 23rev. United States Pharmacopeial Convention, Rockville, pp. 1312-1313.
17. + channel blocking toxin from the scorpion Centruroides noxius Hoffmann. J. Biochem. 116:1994;1383-1391.