Influence of C6 and CNS1 brain tumors on methotrexate pharmacokinetics in plasma and brain tissue

Journal of Neuro-Oncology

Volumn 67, Issue 1-2, 2004, Pages 131-138

  Dukic, Sylvain F ^a   Kaltenbach, Matthieu L ^a   Heurtaux, Tony ^a   Hoizey, Guillaume ^b   Lallemand, Aude ^b   Vistelle, Richard ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b REIMS UNIVERSITY HOSPITAL   (France)

Author keywords

Glioma; Methotrexate; Microdialysis; Pharmacokinetics; Tissue distribution

Indexed keywords

METHOTREXATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL; BOLUS INJECTION; BRAIN TISSUE; BRAIN TUMOR; CONTROLLED STUDY; DIALYSATE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG PENETRATION; DRUG TUMOR LEVEL; EXTRACELLULAR FLUID; GLIOMA; HEMISPHERE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IN VIVO STUDY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; STATISTICAL SIGNIFICANCE; TUMOR MODEL; ULTRAVIOLET RADIATION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AREA UNDER CURVE; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; BRAIN NEOPLASMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIALYSIS SOLUTIONS; DISEASE MODELS, ANIMAL; GLIOMA; MALE; METHOTREXATE; MICRODIALYSIS; RATS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 1842589290     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NEON.0000021820.12444.4c     Document Type: Article

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