Modulation of the baroreceptor reflex by α 2A- adrenoceptors: A study in α 2A knockout mice

British Journal of Pharmacology

Volumn 141, Issue 5, 2004, Pages 851-859

  Niederhoffer, Nathalie ^a   Hein, Lutz ^b   Starke, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

2A Adrenoceptors; Anaesthetized mice; Baroreceptor reflex; Blood pressure; Cardiovascular regulation; Conscious mice; Heart rate; Knockout mice

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; ISOPRENALINE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ARTICLE; BETA ADRENERGIC STIMULATION; BLOOD PRESSURE MEASUREMENT; BRADYCARDIA; CONSCIOUSNESS; CONTROLLED STUDY; HEART RATE; HEART RATE VARIABILITY; KNOCKOUT MOUSE; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ANIMALS; BAROREFLEX; BLOOD PRESSURE; HEART RATE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITROPRUSSIDE; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 1842507421     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705636     Document Type: Article

References (34)

1. AICHER, S.A., MILNER, T.A., PICKEL, V.M. & REIS, D.J. (2000). Anatomical substrates for baroreflex sympathoinhibition in the rat. Brain Res. Bull., 51, 107-110.
2. 2A-adrenergic receptor knockout mice. Mol. Pharmacol., 56, 154-161.
3. BADOER, E., HEAD, G.A. & KORNER, P.I. (1983). Effects of intracisternal and intravenous alpha-methyldopa and clonidine on haemodynamics and baroreceptor-heart rate reflex properties in conscious rabbits. J. Cardiovasc. Pharmacol., 5, 760-767.
4. 3H]idazoxan in rat brain. J. Pharmacol. Exp. Ther., 241, 1079-1091.
5. DAMPNEY, R.A.L. (1994). Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev., 74, 323-364.
6. DAMPNEY, R.A.L., COLEMAN, M.J., FONTES, M.A.P., HIROOKA, Y., HORIUCHI, J., LI, Y.W., POLSON, J.W., POTTS, P.D. & TAGAWA, T. (2002). Central mechanisms underlying short-and long-term regulation of the cardiovascular system. Clin. Exp. Pharmacol. Physiol., 29, 261-268.
7. 2-adrenoceptors in the nucleus tractus solitarius and rostral ventrolateral medulla: an autoradiographic study. Neuroscience, 79, 581-590.
8. 2-adrenoceptor. Pharmacol. Rev., 35, 143-180.
9. GRANATA, A.R., RUGGIERO, D.A., PARK, D.H., JOH, T.H. & REIS, D.J. (1983). Lesions of epinephrine neurons in the rostral ventrolateral medulla abolish the vasodepressor components of baroreflex and cardiopulmonary reflex. Hypertension, 5 (Suppl. V), V80-V84.
10. 2-adrenoceptors in the nucleus ambiguous in baroreflex-mediated bradycardia. Naunyn-Schmiedeberg's Arch. Pharmacol., 323, 199-204.
11. 2-adrenoceptors of nucleus tractus solitarius in baroreflex mediated bradycardia. Naunyn-Schmiedeberg's Arch. Pharmacol., 321, 38-43.
12. 2-Adrenergic receptors rather than imidazoline binding sites mediate the sympatholytic effect of clonidine in the rostral ventrolateral medulla. In: Ventral Brainstem Mechanisms and the Control of Respiration and Blood Pressure. ed. Trouth, C.O., Millis, R.M., Kiwull-Schöne, H.F. & Schläfke M.E. pp. 319-358. New York, Basel and Hong-Kong: Marcel-Dekker.
13. HAEUSLER, G. (1975). Cardiovascular regulation by central adrenergic mechanisms and its alteration by hypotensive drugs. Circ. Res., 36, 223-232.
14. 2-adrenergic receptor subtype function. Rev. Physiol. Biochem. Pharmacol., 142, 161-185.
15. 2-adrenergic receptors regulate sympathetic neurotransmission. Nature, 402, 181-184.
16. 2-adrenoceptors in the modulation of the baroreflex vagal bradycardia. Eur. J. Pharmacol., 71, 455-461.
17. 2- adrenoceptors in the modulation of the sympathetic component of the baroreflex. Neuropharmacology, 22, 1243-1248.
18. KNUEPFER, M.M., MCCANN, R.K. & KAMALU, L. (1993). Effects of cocaine on baroreflex control of heart rate in conscious rats. J. Auton. Nerv. Syst., 43, 257-266.
19. 2-adrenoceptor- mediated modulation of the aortic baroreceptor reflex in the nucleus tractus solitarii of the rat. Brain Res., 526, 313-317.
20. 2A-adrenergic receptor subtype. Hypertension, 34, 403-407.
21. PARATI, G., FRATTOLA, A., DI RIENZO, M., CASTIGLIONI, P. & MANCIA, G. (1997). Broadband spectral analysis of blood pressure and heart rate variability in very elderly subjects. Hypertension, 30, 803-808.
22. PIRES, S.L.S., BARRES, C., SASSARD, J. & JULIEN, C. (2001). Renal blood flow dynamics and arterial pressure lability in the conscious rat. Hypertension, 38, 147-152.
23. 2C- adrenergic receptor-like immunoreactivity in the rat central nervous system. J. Comp. Neurol., 372, 135-165.
24. 2-adrenergic receptor subtype gene expression in rat brain. Mol. Brain Res., 21, 133-149.
25. SINGEWALD, N. & PHILIPPU, A. (1996). Involvement of biogenic amines and amino acids in the central regulation of cardiovascular homeostasis. TIPS, 17, 356-363.
26. SNYDER, D.W., NATHAN, M.A. & REIS, D.J. (1978). Chronic lability of arterial pressure produced by selective destruction of the catecholamine innervation of the nucleus tractus solitarii in the rat. Circ. Res., 43, 662-671.
27. SOUZA NETO, E.P., NEIDECKER, J. & LEHOT, J.J. (2003). To understand blood pressure and heart rate variability. Ann. Fr. Anesth. Reanim., 22, 425-452.
28. STAUSS, H.M. (2002). Baroreceptor reflex function. Am. J. Physiol., 283, R284-R286.
29. 2-adrenergic receptors in nucleus tractus solitarius is required for the baroreceptor reflex. Brain Res., 576, 297-303.
30. SZABO, B. (2002). Imidazoline antihypertensive drugs: a critical review on their mechanism of action. Pharmacol. Ther., 93, 1-35.
31. SZABO, B., FRITZ, T. & WEDZONY, K. (2001). Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex. Br. J. Pharmacol., 134, 295-304.
32. 2B- adrenergic receptor subtypes in brain. Hypertension, 27, 449-455.
33. 2-adrenoceptor blockade in the rat. Eur. J. Pharmacol., 453, 287-297.
34. YAMAZAKI, T. & NINOMIYA, I. (1993). Noradrenaline contributes to modulation of the carotid sinus baroreflex in the nucleus solitarii area in the rabbit. Acta Physiol. Scand., 149, 1-6.