Effect of a selective nonsteroidal anti-inflammatory inhibitor of cyclooxygenase-2 on the small bowel of rats

Brazilian Journal of Medical and Biological Research

Volumn 37, Issue 3, 2004, Pages 333-336

  Leite, A Z A ^a,b   Sipahi, A M ^a   Damiao A O M C ^a   Garcez, A T ^a   Buchpiguel, C A ^a   Lopasso, F P ^a   Lordello, M L L ^a   Agostinho, C L O ^a   Laudanna, A A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Departamento de Medicina   (Brazil)

Author keywords

COX 2 inhibitor; Enteropathy; Indomethacin; Intestinal permeability; Nonsteroidal anti inflammatory drugs; Rofecoxib

Indexed keywords

CHROMIUM 51; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; EDETIC ACID; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; ROFECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG SAFETY; ENTEROPATHY; ENZYME INHIBITION; FEEDING; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; RAT; SCORING SYSTEM; SINGLE DRUG DOSE; SMALL INTESTINE; STOMACH INJURY;

ANIMALIA; RATTUS NORVEGICUS;

EID: 1842503105     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2004000300007     Document Type: Article

References (20)

1. Tibble JA, Sigthorsson G, Foster R, Scott D, Fagerhol MK, Roseth A & Bjarnason I (1999). High prevalence of NSAID enteropathy as shown by a simple fecal test. Gut, 45: 362-366.
2. 111Indium-labelled polymorphonuclear leucocyte scans in rheumatoid arthritis - an important clinical cause of false positive results. British Journal of Rheumatology, 25: 167-170.
3. Morris AJ, Madhok R, Sturrock RD, Capell HA & MacKenzie JF (1991). Enteroscopic diagnosis of small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs. Lancet, 337: 520 (Abstract).
4. Allison MC, Howatson AG, Torrance CJ, Lee FD & Russell RI (1992). Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. New England Journal of Medicine, 327: 749-754.
5. Lengeling RW, Mitros FA, Brennan JA & Schulze KS (2003). Ulcerative ileitis encountered at ileo-colonoscopy: Likely role of nonsteroidal agents. Clinical Gastroenterology and Hepatology, 1: 160-169.
6. Somasundaram S, Hayllar H, Rafi S, Wrigglesworth JM, MacPherson AJ & Bjarnason I (1995). The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: A review and a hypothesis. Scandinavian Journal of Gastroenterology, 30: 289-299.
7. Mingatto FE, Santos AC, Uyemura SA, Jordani MC & Curti C (1996). In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: Respiration and ATP synthesis. Archives of Biochemistry and Biophysics, 334: 303-308.
8. Mahmud T, Rafi SS, Scott DL, Wrigglesworth JM & Bjarnason I (1996). Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis and Rheumatism, 39: 1998-2003.
9. Bjarnason I, Williams P, So A, Zanelli GD, Levi AJ, Gumpel JM, Peters TJ & Ansell B (1984). Intestinal permeability and inflammation in rheumatoid arthritis: Effects of non-steroidal anti-inflammatory drugs. Lancet, 2: 1171-1174.
10. 51Cr-EDTA in rats with experimentally induced enteropathy. Gut, 26: 579-585.
11. Bjarnason I, Williams P, Smethurst P, Peters TJ & Levi AJ (1986). Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine. Gut, 27: 1292-1297.
12. Mahmud T, Somasundaram S, Sigthorsson G et al. (1998). Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat. Gut, 43: 775-782.
13. Tanaka A, Hase S, Miyazawa T & Takeuchi K (2002). Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: A key to nonsteroidal anti-inflammatory drug-induced intestinal damage. Journal of Pharmacology and Experimental Therapeutics, 300: 754-761.
14. Shah AA, Thjodleifsson B, Murray FE et al. (2001). Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: A comparison of nimesulide and naproxen. Gut, 48: 339-346.
15. Tibble JA, Sigthorsson G, Foster R & Bjarnason I (2000). Comparison of the intestinal toxicity of celecoxib, a selective COX-2 inhibitor, and indomethacin in the experimental rat. Scandinavian Journal of Gastroenterology, 35: 802-807.
16. Sigthorsson G, Crane R, Simon T, Hoover M, Quan H, Bolognese J & Bjarnason I (2000). COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: A double blind crossover study comparing rofecoxib with placebo and indomethacin. Gut, 47: 527-532.
17. Ford J, Martin SW & Houston JB (1995). Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat. Journal of Pharmacological and Toxicological Methods, 34: 9-16.
18. Suenaert P, Bulteel V, Den Hond E, Geypens B, Monsuur F, Luypaerts A, Ghoos Y & Rutgeerts P (2003). In vivo influence of nicotine on human basal and NSAID-induced gut barrier function. Scandinavian Journal of Gastroenterology, 38: 399-408.
19. Leite AZ, Sipahi AM, Damiao AO et al. (2001). Protective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: A new mechanism. Gut, 48: 163-167.
20. Reuter BK, Asfaha S, Buret A, Sharkey KA & Wallace JL (1996). Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. Journal of Clinical Investigation, 98: 2076-2085.