The Tricalbin C2 Domains: Lipid-Binding Properties of a Novel, Synaptotagmin-Like Yeast Protein Family

Biochemistry

Volumn 43, Issue 13, 2004, Pages 3987-3995

  Schulz, Timothy A ^a   Creutz, Carl E ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CALCIUM; LIPIDS; OLIGOMERS; PROTEINS;

LIPID-BINDING PROPERTIES; TRICALBIN C2 DOMAINS;

YEAST;

CALCIUM; FUNGAL PROTEIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; SYNAPTOTAGMIN; SYNAPTOTAGMIN I; TRICALBIN; TRICALBIN 1; TRICALBIN 2; TRICALBIN 3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; FLUOROMETRY; MEMBRANE BINDING; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SEDIMENTATION;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; LIPID BILAYERS; MEMBRANE GLYCOPROTEINS; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PEPTIDES; PHOSPHATIDYLSERINES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; SYNAPTOTAGMIN I; SYNAPTOTAGMINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 1842486857     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036082w     Document Type: Article

References (36)

1. Sudhof, T. C. (2001) Synaptotagmins: why so many? J. Biol. Chem. 277, 7629-7632.
2. Sudhof, T. C., and Rizo, J. (1996) Synaptotagmins: C2 domain proteins that regulate membrane traffic, Neuron 17, 379-388.
3. Davis, D. B., Doherty, K. R., Delmonte, A. J., and McNally, E. M. (2002) Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains, J. Biol. Chem. 277, 22883-22888.
4. Yoshihara, M., and Littleton, J. T. (2002) Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release, Neuron 36, 897-908.
5. Damer, C. K., and Creutz, C. E. (1994) Synergistic membrane interactions of the two C2 domains of synaptotagmin, J. Biol. Chem. 49, 31115-31123.
6. 2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis, J. Cell Biol. 154, 1117-1123.
7. Creutz, C. E., and Snyder, S. L. (1999) The tricalbins: yeast synaptotagmin homologues? Mol. Biol. Cell 10, 215a.
8. Adolfsen, B., and Littleton, J. T. (2000) Genetic and molecular analysis of the synaptotagmin family, Cell. Mol. Life Sci. 58, 393-402.
9. Fukuda, M. (2003) Molecular cloning, expression, and characterization of a novel class of synaptotagmin (SytXIV) conserved from Drosophila to humans, J. Biochem. 133, 641-649.
10. Creutz, C. E., Snyder, S. L., and Schulz, T. A. (2003) Characterization of the yeast tricalbins: membrane-bound multi-C2 domain proteins that form complexes involved in membrane trafficking, Cellular and Molecular Life Sciences, submitted for publication.
11. Zuniga, S., Boskovic, J., Jimenez, A., Ballesta, J. P., and Remacha, M. (1999) Disruption of six Saccharomyces cerevisae novel genes and phenotypic analysis of the deletants, Yeast 15, 945-953.
12. Seeley, E. S., Kato, M., Margolis, N., Wickner, W., and Eitzen, G. (2002) Genomic analysis of homotypic vacuole fusion, Mol. Biol. Cell 13, 782-794.
13. Hallstrom, T. C., Lambert, L., Schorling, S., Balzi, E., Goffeau, A., and Moye-Rowley, W. S. (2001) Coordinate control of sphingolipid biosynthesis and multidrug resistance in Saccharomyces cerevisae, J. Biol. Chem 276, 23674-23680.
14. Nawrocki, A., Fey, S. J., Goffeau, A., Roepstorff, P., and Larsen, P. M. (2001) The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance, Proteomics 1, 1022-1032.
15. Guan, K. L., and Dixon, J. E. (1991) Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase, Anal. Biochem. 192, 262-267.
16. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of micrograms quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72, 248-254.
17. Rebecchi, M., Peterson, A., and McLaughlin, S. (1992) Phosphoinositide-specific phospholipase C-delta 1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate, Biochemistry 31, 12742-12747.
18. Nalefski, E. A., and Falke, J. J. (1996) The C2 domain calcium-binding motif: structural and functional diversity, Protein Sci. 5, 2375-2390.
19. Cheever, M. L., Sato, T. K., de Beer, T., Kutateladze, T. G., Emr, S. D., and Overduin, M. (2001) Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes, Nat. Cell Biol. 3, 613-618.
20. Tuller, G., Nemec, T., Hrastnik, C., and Daum, G. (1999) Lipid compositions of subcellular membranes of an FY1679-derived haploid yeast wild-type strain grown on different carbon sources, Yeast 15, 1555-1564.
21. Creutz, C. E., Snyder, S. L., and Kambouris, N. G. (1991) Calcium-dependent secretory vesicle-binding and lipid-binding proteins of Saccharomyces cerevisae, Yeast 7, 229-244.
22. Odorizzi, G., Babst, M., and Emr, S. D. (1998) Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body, Cell 95, 847-858.
23. Gary, J. D., Wurmser, A. E., Bonangelino, C. J., Weisman, L. S., and Emr, S. D. (1998) Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis, J. Cell Biol. 143, 65-79.
24. 2+-permeable channel in the yeast vacuolar membrane, Proc. Natl. Acad. Sci. U.S.A. 98, 7801-7805.
25. 2+ in yeast, Mol. Cell. Biol. 20, 6686-6694.
26. Tisi, R., Baldassa, S., Belotti, F., and Martegani, E. (2002) Phospholipase C is required for glucose-induced calcium influx in budding yeast, FEBS Lett. 520, 133-138.
27. Csutora, P., Su, Z., Kim, H. Y., Bugrim, A., Cunningham, K. W., Nuccitelli, R., Keizer, J. E., Hanley, M. R., Blalock, J. E., and Marchase, R. B. (1999) Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores, Proc. Natl. Acad. Sci. U.S.A. 96, 121-126.
28. 2+-sensitive fluorescence dye indo-1, FEBS Lett. 256, 55-61.
29. 2+ release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue, J. Cell Biol. 156, 29-34.
30. Osbome, S. L., Herreros, J., Bastiaens, P. I., and Schiavo, G. (1999) Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium, J. Biol. Chem. 274, 59-66.
31. 2+ binding, J. Biol. Chem. 272, 14314-14319.
32. Littleton, J. T., Serano, T. L., Rubin, G. M., Ganetzky, B., and Chapman, E. R. (1999) Synaptic function modulated by changes in the ratio of synaptotagmin I and IV, Nature 400, 757-760.
33. 2+-dependent and -independent activities of neural and non-neural synaptotagmins, Nature 375, 594-599.
34. Hudson, A. W., and Birnbaum, M. J. (1995) Identification of a nonneuronal form of synaptotagmin, Proc. Natl. Acad. Sci. U.S.A. 92, 5895-5899.
35. 2+-binding module, Biochemistry 40, 5854-5860.
36. 2+ affinities, EMBO J. 21, 270-280.