Expression of the cyclin-dependent kinase inhibitor p27 in transitional cell bladder cancers: Is it a good predictor for tumor behavior?

International Urology and Nephrology

Volumn 35, Issue 2, 2003, Pages 181-188

  Doganay, Latife ^a   Altaner, Semsi ^a   Bilgi, Selcuk ^a   Kaya, Esat ^a   Ekuklu, Galip ^a   Kutlu, Kemal ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

Bladder; p27; p53; PCNA; Progression; Recurrence; Transitional cell carcinoma

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; PARAFFIN; PROTEIN P27; PROTEIN P53;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE; CONTROLLED STUDY; CYSTECTOMY; DISEASE ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; TRANSITIONAL CELL CARCINOMA; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, TRANSITIONAL CELL; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; URINARY BLADDER NEOPLASMS;

EID: 1842485931     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:UROL.0000020301.39181.03     Document Type: Article

References (40)

1. Cotran RS, Kumar VK, Collins T. Pathologic Basis of Disease, 6th edn. Philadelphia, Pennsylvania: W.B. Saunders Company; 1999: 95-96.
2. kip1 in human breast cancers. Clin Can Res 1997; 3: 1879-1887.
3. Xiong Y, Connolly T, Futcher B et al. Human D-type cyclin. Cell 1991; 65: 691-699.
4. Hall PA, Levision DA. Review: assessment of of cell proliferation in histological material. J Clin Pathol 1990; 43: 184-192.
5. Xiong Y, Zhang H, Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 1992; 71: 505-514.
6. Liu Y, Marraccino RL, Keng PC. Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle. Biochemistry 1989; 28: 2967-2974.
7. Finlay CA, Hinds PW, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell 1989; 57: 1083-1093.
8. Lipponen PK. Over-expression of p53 nuclear oncoprotein in transitional-cell bladder cancer and its prognostic value. Int J Cancer 1993; 53: 365-370.
9. Esrig D, Spruck III CH, Nichols PW et al. p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. AJP 1993; 143: 1389-1397.
10. Mostofi F. Histological Typing of Urinary Bladder Tumors. Geneva: World Health Organization, 1973.
11. UICC. TNM Classification of Malignant Tumours, 4th edn. Berlin: Springer-Verlag, 1992.
12. kip1 and degree of malignancy in human breast and colorectal cancers. Proc Natl Acad Sci USA 1997; 94: 6380-6385.
13. Sherr CJ. G1 phase progression: cycling on cue. Cell 1994; 79: 551-555.
14. Hunter T, Pines J. Cyclins and cancer. II: cyclin D and CDK inhibitors come of age. Cell 1994; 79: 73-582.
15. kip1 chromosomal mapping to 12p. 12-12p 13.1 and absence of mutation in human tumors. Canser Res 1995; 55: 1211-1214.
16. kip1, to regions involved in human cancer. Cancer Res 1995; 55: 1199-1205.
17. kip1 gene to 12p13 and its analysis in leukemias. Cancer Res 1995; 55: 1206-1210.
18. kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 1999; 154: 313-323.
19. Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-CDK protein kinase activity is related to p21. Cell 1994; 78: 67-74.
20. kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994; 78: 59-66.
21. kip1, a cyclin-Cdk inhibitor, links transforming growth-β and contact inhibition to cell cycle arrest. Genes Dev 1994; 8: 9-22.
22. kip1 for restriction point control of the fibroblast cell cycle. Science 1996; 272: 877-880.
23. kip1. Genes Dev 1997; 11: 1464-1478.
24. kip1 down regulation, passage through the restriction point and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts. Mol Cell Biol 1997, 17: 5348-5358.
25. kip1 in C3H 10 T1/2 mouse fibroblasts. Cancer Res 1995; 55: 1413-1416.
26. kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancers. Cancer Res 1999; 59: 3245-3250.
27. kip1 and cycling E in transitional cell carcinoma of the bladder correlates with tumor grade and patients survival. Am J Pathol 1999; 155: 1129-1136.
28. Esposito V, Baldi A, De Luca A et al. Prognostic role of the cycling-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res 1997; 57: 3381-3385.
29. kip1. Hum Pathol 2000; 31: 751-760.
30. kip1 and cyclin E, protein levels is associated with progression from superficial into invasive bladder cancer. Br J Cancer 2001; 84: 1242-1251.
31. kip1 protein: prognostic implications in primary breast cancer. Nat Med 1997; 3: 227-230.
32. Porter PL, Malone KE, Heagerty PJ et al. Expression of cell-cycle regulators p27 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 1997; 3: 222-225.
33. Loda M, Cukor B, Tam SW et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 1997; 3: 231-233.
34. kip1 is expressed preferentially in early stages of urothelial carcinoma. Urology 2000; 56: 689-695.
35. kip1 protein in transitional cell carcinoma of the upper urinary tract. Mod Pathol 2001; 14: 371-376.
36. Lipponen PK, Eskelinen MJ. Cell proliferation of transitional cell bladder tumours determined by PCNA/cyclin immunostaining and its prognostic value. Br J Cancer 1992; 66: 171-176.
37. Kuczyk MA, Serth J, Bokemeyer C et al. Value of the proliferation status (PCNA) and p53 immunohistochemistry as a prognostic factor for the clinical course of superficial cancer of the urinary bladder. Urologe A 1995; 34: 146-152
38. Iizumi T, Iiyama T, Tanaka W et al. Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder. Urol Int 1997; 59: 81-87.
39. kip1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. Cancer Res 1998; 58: 1042-1047.
40. Jacks T, Weinberg RA. The expanding role of cell cycle regulators. Science 1998; 280: 1035-1036.