Rapid and Accurate Prediction of Degradant Formation Rates in Pharmaceutical Formulations Using High-Performance Liquid Chromatography-Mass Spectrometry

Journal of Pharmaceutical Sciences

Volumn 93, Issue 4, 2004, Pages 838-846

  Darrington, Richard T ^a   Jiao, Jim ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Arrhenius extrapolation; Degradation kinetics; Formulation; Initial rate method; Liquid chromatography mass spectrometry; Nonlinear regression; Stability prediction

Indexed keywords

MACROLIDE;

ACCURACY; ARTICLE; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; MASS SPECTROMETRY; NONLINEAR REGRESSION ANALYSIS; PREDICTION; QUANTITATIVE ANALYSIS; SHELF LIFE;

EID: 1842482936     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20006     Document Type: Article

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