Molecular studies on the diversification of hemagglutinin - Specific human neonatal repertoire subsequent to immunization with naked DNA

Vaccine

Volumn 22, Issue 13-14, 2004, Pages 1624-1630

  Bona, Constantin ^a   Radu, Dorel ^a,b   Kodera, Takao ^a,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CANTACUZINO INSTITUTE   (Romania)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

DNA immunization; Influenza viruses; Neonatal immunity; RAG

Indexed keywords

ANTIBODY; DNA VACCINE; HEMAGGLUTININ; INFLUENZA VACCINE; LIVE VACCINE; NAKED DNA; RECEPTOR;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; DRUG EFFECT; DRUG MEGADOSE; DRUG RESPONSE; DRUG TOLERABILITY; GENE EXPRESSION; GENE THERAPY; GENETIC ANALYSIS; GERMINAL CENTER; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOCHEMISTRY; IMMUNOGENICITY; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS; LETHAL DOSE; MEMORY CELL; MOLECULAR BIOLOGY; NEWBORN; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTECTION; SURVIVAL; T LYMPHOCYTE;

ANIMALS; ANIMALS, NEWBORN; DNA, VIRAL; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNIZATION; INFANT, NEWBORN; INFLUENZA VACCINES; MICE; ORTHOMYXOVIRIDAE; PLASMIDS; VACCINES, DNA;

EID: 1842479861     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2003.10.045     Document Type: Article

References (20)

1. Billingham R., Brent L., Medawar P. Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Proc. Roy. Soc. London. 239:1956;44-45.
2. Press J.L. Neonatal immunity and somatic mutation. Intern. Rev. Immunol. 19:2000;265-287.
3. Cancro M.P., Wyle D., Gerhard W., Klinman N.R. Patterned acquisition of the antibody repertoire. Diversity of the hemagglutinin-specific B cell repertoire in neonatal Balb/c mice. Proc. Natl. Acad. Sci. USA. 76:1979;6577-6581.
4. Moran T.M., Monestier M., Lai A.C.K., Norton G., Reale M.A., Thompson M.A.et al. Characterization of variable-region genes and crossreactive idiotypes of antibodies specific for antigens of various influenza viruses. Viral Immunol. 1:1987;1-12.
5. Clarke S.H., Staudt L.M., Kavaler J., Schwartz D., Gerhard W.U., Weigert M.G. V region usage and somatic mutation in the primary and secondary responses to influenza virus hemmaglutinin. J. Immunol. 144:1990;2795-2801.
6. Stark S.E., Caton A.J. Antibodies that are specific for a single amino acid interchange in a protein epitope use structurally distinct variable regions. J. Exp. Med. 174:1991;613-624.
7. Kienker L.J., Korostoff J.M., Cancro M.P. Patterns of Ig V region expression among neonatal hemagglutinin-responsive B cells. Evidence for non-random Vh gene representation during later stages of development. J. Immunol. 141:1988;3634-3641.
8. Bot A., Antohi S., Bot S., Garcia-Sastre A., Bona C. Induction of humoral and cellular immunity against influenza virus by immunization of newborn mice with a plasmid bearing a hemagglutinin gene. Intern. Immunol. 9:1997;1641-1650.
9. Pertmer T.R., Robinson H.L. Studies of antibody responses following neonatal immunization with influenza hemagglutinin DNA or protein. Virology. 257:1999;406-414.
10. Antohi S., Bot A., Manfield L., Bona C. The reactivity pattern of hemagglutinin-specific clonotypes from mice immunized as neonates or adults with naked DNA. Intern. Immunol. 10:1998;663-668.
11. Bot A., Antohi S., Bona C. Immune response of neonates elicited by somatic transgene vaccination with naked DNA. Frontiers Biosci. 2:1997;173-188.
12. Oettinger M.A., Schatz D.G., Gorka C., Baltimore D. RAG-1 and RAG-2 adjacent genes that synergistically activate V(D)J recombination. Science. 248:1990;1517-1523.
13. Constantinescu A., Schlissel M.S. Changes in locus specific V(D)J recombinase activity during B cell development. J. Exp. Med. 185:1997;609-620.
14. Bot A., Bona C. Genetic immunization of neonates. Micr. Inf. 4:2002;511-520.
15. MacLennan I.C.M. Germinal centers. Ann. Rev. Immunol. 12:1994;117-139.
16. Magari M., Sawatari T., Kawano Y., Cascalho M., Wabl M., Kanayama N.et al. Contribution of light chain rearrangement in peripheral B cells to the generation of high affinity of antibodies. Eur. J. Immunol. 32:2002;957-966.
17. Hikida M., Mori M., Takai T., Tomochika K., Hamatani K., Ohmori H. Re-expression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science. 274:1996;2092-2094.
18. Hikida M., Mori M., Kawabata T., Takai T., Ohmori H. Characterization of B cells expressing recombination activating genes in germinal centers of immunized mouse lymph nodes. J. Immunol. 158:1997;2509-2512.
19. Han S., Zheng B., Schatz D.G., Spandopolou E., Kelsoe G. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal centers B cells. Science. 274:1996;2094-2097.
20. Kodera T., McGaha T.L., Phelps R., Paul W.E., Bona C.A. Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-β production by fibroblasts. Proc. Natl. Acad. Sci USA. 99:2002;3800-3805.