The reactivity pattern of hemagglutinin-specific clonotypes from mice immunized as neonates or adults with naked DNA

International Immunology

Volumn 10, Issue 5, 1998, Pages 663-668

  Antohi, Stefan ^a   Bot, Adrian ^a   Manfield, Laura ^a   Bona, Constantin ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

B cell; Genetic vaccination; Influenza virus; Isotypes

Indexed keywords

HEMAGGLUTININ; INFLUENZA VACCINE; VIRUS ANTIBODY;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; IMMUNIZATION; MOUSE; NEWBORN; NONHUMAN; PLASMID; PRIORITY JOURNAL; SURVIVAL; VACCINATION;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, VIRAL; B-LYMPHOCYTES; CLONE CELLS; DNA, VIRAL; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; IMMUNIZATION; IMMUNOLOGIC MEMORY; INFLUENZA A VIRUS; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; VACCINES, DNA;

EID: 0031946557     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.5.663     Document Type: Article

References (18)

1. Billingham, R., Brent, L. and Medawar, P. 1956 Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Proc. Roy. Soc. London 239:44.
2. Cancro, M. P., Wylie, D. E., Gerhard, W. and Klinman, N. R. 1979 Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin specific B cell repertoire in neonatal BALB/c mice. Proc. Natl Acad. Sci. USA 76:6577.
3. Clarke, S. H., Staudt, L. M., Kavaler, J., Schwartz, D., Gerhard, W. and Weigert, M. G. 1990 V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J. Immunol. 144:2795.
4. Bot, A., Antohi, S., Bot, S., Garcia-Sastre, A. and Bona, C. 1997 Induction of humoral and cellular immunity against influenza virus by immunization of newborn mice with a plasmid bearing HA gene. Int. Immunol. 9:101.
5. Garcia-Sastre, A., Muster, T., Barclay, W. S., Percy, N. and Palese, P. 1994. Use of mammalian ribosomal entry site element for expression of a foreign protein by a transfectant influenza virus. J. Virol. 68:6254.
6. Burnet, F. M. and Lind, P. E. 1949. Recombination of characters between two influenza virus strains. Aust. J. Sci. 12:109.
7. Bot, A., Bot, S. and Bona, C. 1998. Enhanced protection following neonatal immunization with a combination of plasmids expressing NP and HA of influenza virus. Vaccine, in press.
8. Klinman, N. R. 1972. The mechanism of antigenic stimulation of primary and secondary clonal precursor cells. J. Exp. Med. 136:241.
9. Rosner, B. 1995. Fundamental of Biostatistics, 4th edn, p. 510. Duxbury Press, New York.
10. Beverly, P. C. L. 1997. Vaccine immunity, Immunol. Today 18:413.
11. Bona, C. and Bot, A. 1997. Neonatal immunoresponsiveness. The Immunologist 5:5.
12. Cambier, J. C., Kettman, J. R., Vitetta, E. S. and Uhr, J. W. 1976. Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B cell tolerance. J. Exp. Med. 144:289.
13. Monroe, J. G. 1996. Tolerance sensitivity of immature-stage B cells. Can developmentally regulated B cell antigen receptor (BCR) signal transduction play a role ? J. Immunol. 156:2657.
14. fgr1. J. Immunol. 154:1919.
15. Forsthuber, T., Yip, H. C. and Lehman, P. V. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science 271:1728.
16. Sun, S., Beard, C., Joenisch, R., Jones, P. and Sprent, J. 1997. Mitogenicity of DNA from different organisms for murine B cells. J. Immunol. 159:3119.
17. Coutelier, J. P., Vanderlogt, T. T. M., Heessen, F. V. A., Vink, A. and Van Snick, J. 1988. Virally induced modulation of murine IgG antibody subclasses. J. Exp. Med. 184:1537.
18. Raz, E., Tighe, H., Sato, Y., Corr, M., Dudler, J. A., Roman, M., Swain, S. L., Spiegelberg, H. L. and Carson, D. A. 1996. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc. Natl Acad. Sci. USA 93:5141.