Synergistic interaction of endocrine-disrupting chemicals: Model development using an ecdysone receptor antagonist and a hormone synthesis inhibitor

Environmental Toxicology and Chemistry

Volumn 23, Issue 4, 2004, Pages 1085-1091

  Mu, Xueyan ^a   LeBlanc, Gerald A ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Disruptors; Endocrine; Invertebrate; Mixtures; Synergy

Indexed keywords

ALGORITHMS; HORMONES; MATHEMATICAL MODELS; SYNTHESIS (CHEMICAL); TOXIC MATERIALS; TOXICITY;

MATERNAL TRANSFER; SYNERGISTIC INTERACTIONS;

ENVIRONMENTAL ENGINEERING;

CHEMICAL COMPOUND; ECDYSONE; FENARIMOL; HORMONE INHIBITOR; TESTOSTERONE; TOXIC SUBSTANCE;

ECOTOXICOLOGY; ENDOCRINE SYSTEM; HORMONE; ZOOPLANKTON;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL MODEL; CHEMICAL INTERACTION; CONTROLLED STUDY; DAPHNIA; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEVELOPMENT; ENDOCRINE DISEASE; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE RECEPTOR INTERACTION; HORMONE SYNTHESIS; MATHEMATICAL MODEL; MOLECULAR INTERACTION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROGENY; RADIOIMMUNOASSAY; SIGNAL TRANSDUCTION; TOXICITY TESTING;

ALGORITHMS; ANIMALS; DAPHNIA; DRUG INTERACTIONS; ECDYSTEROIDS; EMBRYONIC DEVELOPMENT; ENDOCRINE SYSTEM; ENVIRONMENTAL POLLUTANTS; FUNGICIDES, INDUSTRIAL; MODELS, THEORETICAL; PYRIMIDINES; RISK ASSESSMENT; TESTOSTERONE;

ANIMALIA; CRUSTACEA; DAPHNIA; DAPHNIA MAGNA; INVERTEBRATA;

EID: 1842458477     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/03-273     Document Type: Article

References (40)

1. Kolpin DW, Furlong DT, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ Sci Technol 36:1202-1211.
2. Center for Disease Control. 2003. Second national report on human exposure to environmental chemicals. NCEH Publication 03-0022. Atlanta, GA, USA.
3. Bliss C. 1939. The toxicity of poisons applied jointly. Ann Appl Biol 26:585-615.
4. Broderius SJ, Kahl MD, Hoglund MD. 1995. Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals. Environ Toxicol Chem 14:1591-1605.
5. Kortenkamp A, Altenburger R. 1998. Synergisms with mixtures of xenoestrogens: A reevaluation using the method of isoboles. Sci Total Environ 221:59-73.
6. Grantley DC, Gennings C, Zacharewski TR, Bollapudi BB, Carney EW. 2002. An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals: A pilot study. Toxicol Sci 68:349-360.
7. Rajapakse N, Silva E, Kortenkamp A. 2002. Combining xenoestrogens at levels below individual no-observed-effect-concentrations dramatically enhances steroid hormone action. Environ Health Perspect 110:917-921.
8. Rooney AA, Guillette LJ. 2000. Contaminant interactions with steroid receptors: Evidence for receptor binding. In Guillette LJ, Crain DA, eds, Environmental Endocrine Disruptors. Taylor & Francis, New York, NY, USA, pp 82-125.
9. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA, Wilson EM. 1995. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375:581-585.
10. II cell in vitro assay. Environ Toxicol Chem 20:2038-2046.
11. Pont A, Williams PL, Azhar S, Reitz RE, Bochra C, Smith ER, Stevens DA. 1982. Ketoconazole blocks testosterone synthesis. Arch Intern Med 142:2137-2140.
12. Wilson VS, LeBlanc GA. 1999. The contribution of hepatic inactivation of testosterone to the lowering of serum testosterone levels by ketoconazole. Toxicol Sci 54:128-137.
13. Mu X, LeBlanc GA. 2002a. Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna. J Exp Zool 292:287-292.
14. Darvas B, Rees HH, Kuwano E, Belai I, Matolcsy G, Timar T, Hoggard N, Tag El-Din MH. 1990. Some inhibitors of microsomal ecdysone 20-monooxygenase. Invertebrate Reproduction and Development 118:110.
15. Mu X, LeBlanc GA. 2002b. Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity. Gen Comp Endocrinol 129:127-133.
16. Subramoniam T. 2000. Crustacean ecdysteroids in reproduction and embryogenesis. Comp Biochem Physiol C 125:135-156.
17. Kast-Hutcheson K, Rider CV, LeBlanc GA. 2001. The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna. Environ Toxicol Chem 20:502-509.
18. LeBlanc GA, Mu X, Rider CV. 2000. Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna. Environ Health Perspect 108:1133-1138.
19. Finney DJ. 1942. The analysis of toxicity tests on mixtures of poisons. Ann Appl Biol 29:82-94.
20. Zar JH. 1996. Biostatistical Analysis. Prentice Hall, Upper Saddle River, NJ, USA.
21. Cuzin-Roudy J, Strambi C, Strambi A, Delbecque JP. 1989. Hemolymph ecdysteroids and molt cycle in males and females of Siriella armata M.-Edw. (Crustacea:Mysidacea): Possible control by the M1-ME X-organ of the eyestalk. Gen Comp Endocrinol 74:96-109.
22. Wheatly MG, Hart MK. 1995. Hemolymph ecdysone and electrolytes during the molting cycle of crayfish: A comparison of natural molts with those induced by eyestalk removal of multiple limb autotomy. Physiol Zool 68:583-607.
23. Wilder MN, Okada S, Fusetani N, Aida K. 1995. Hemolymph profiles of juvenoid substances in the giant freshwater prawn Macrobrachium rosenbergii in relation to reproduction and molting. Fish Sci 61:175-176.
24. Okumura T, Aida K. 2000. Fluctuations in hemolymph ecdysteroid levels during the reproductive and non-reproductive molt cycles in the giant freshwater prawn Macrobrachium rosenbergii. Fish Sci 66:876-883.
25. Nijhout HF. 1998. Insect Hormones. Princeton University Press, Princeton, NJ, USA.
26. Grieneisen ML, Warren JT, Gilbert LI. 1993. Early steps in ecdysteroid biosynthesis: Evidence for the involvement of cytochrome P-450 enzymes. Insect Biochem Mol Biol 23:13-23.
27. Webb P, Lopez GN, Uht RM, Kushner PJ. 1995. Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9:443-556.
28. Wong C, Kelce WR, Sar M, Wilson EM. 1995. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J Biol Chem 270:1998-2003.
29. Tabata Y, Iizuka Y, Masuda NT, Shinei R, Kurihara K, Okonogi T, Kurata Y. 2002. In vitro and in vivo characterization of a novel nonsteroidal progesterone receptor antagonist derived from the fungal metabolite PF1092C. J Steroid Biochem Mol Biol 82:217-223.
30. Bucher JR, Lucier G. 1998. Current approaches towards chemical mixture studies at the National Institute of Environmental Health Sciences and the U.S. National Toxicology Program. Environ Health Perspect 106(Suppl. 6):1295-1298.
31. Groten JP, Tajima O, Feron VJ, Schoen ED. 1998. Statistically designed experiments to screen chemical mixtures for possible interactions. Environ Health Perspect 106(Suppl. 6):1362-1365.
32. Land MF, Geer PJ, Bonzek CF, Austin HM. 1995. Juvenile finfish and blue crab stock assessment program bottom trawl survey annual data summary series. Report 124, Volume 1994. Virginia Institute of Marine Science, Gloucester Point, VA, USA.
33. Land MF, Geer PJ, Bonzek CF, Austin HM. 1996. Juvenile finfish and blue crab stock assessment program York River random bottom trawl survey data summary report. Report 124, Volume R1991-1990. Virginia Institute of Marine Science, Gloucester Point, VA, USA.
34. Land MF, Geer PJ, Bonzek CF, Austin HM. 1996. Juvenile finfish and blue crab stock assessment program York River random bottom trawl survey data summary report. Report 124, Volume R1991-1994. Virginia Institute of Marine Science, Gloucester Point, VA, USA.
35. Stevens BG, Otto RS, Haaga JA, MacIntosh RA. 1998. Report to industry on the 1997 Eastern Bering Sea Crab Survey. Report 98-02. National Marine Fisheries Service, Alaska Fisheries Science Center, Kodiak, AK, USA.
36. Reyes GG, Villagrana C, Alvarez GL. 1999. Environmental conditions and pesticide pollution of two coastal ecosystems in the Gulf of California, Mexico. Ecotoxicol Environ Saf 44:280-286.
37. Anderson BS, Hunt JW, Phillips BM, Fairey R, Roberts CA, Oakden JM, Puckett HM, Stephenson M, Tjeerdema RS, Long ER, Wilson CJ, Lyons JM. 2001. Sediment quality in Los Angeles Harbor, USA: A triad assessment. Environ Toxicol Chem 20:359-370.
38. Long ER, Hong CB, Severn CG. 2001. Relationships between acute sediment toxicity in laboratory tests and abundance and diversity of benthic infauna in marine sediments: A review. Environ Toxicol Chem 20:46-60.
39. Oberdorster EA, Cheek AO. 2001. Gender benders at the beach: Endocrine disruption in marine and estuarine: organisms. Environ Toxicol Chem 20:23-36.
40. Dinan L, Bourne PC, Meng Y, Sarker SD, Tolentino RB, Whiting P. 2001. Assessment of natural products in the Drosophila melanogaster BII cell bioassay for ecdysteroid agonist and antagonist activities. Cell Mol Life Sci 58:321-342.