An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals: A pilot study

Toxicological Sciences

Volumn 68, Issue 2, 2002, Pages 349-360

  Charles, Grantley D ^a   Gennings, C ^b   Zacharewski, Timothy R ^c   Gollapudi, B Bhaskar ^a   Carney, Edward W ^a  

^a DOW CHEMICAL COMPANY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c Michigan State University   (United States)

Author keywords

17 estradiol; Addivity; Diethylstilbestrol; Endocrine; Estrogen receptor; Mixture; Response surface; Synergy

Indexed keywords

DIETHYLSTILBESTROL; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; SOMATOMEDIN C; ESTROGEN;

ARTICLE; CELL STRAIN MCF 7; CHEMICAL INTERACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONLINEAR SYSTEM; PILOT STUDY; REPORTER GENE; STATISTICAL ANALYSIS; ANIMAL; BIOASSAY; BREAST TUMOR; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETIC TRANSCRIPTION; GENETICS; METHODOLOGY; MOUSE; MOUSE STRAIN; NEWBORN; ORGAN SIZE; PATHOLOGY; UTERUS;

ANIMAL; ANIMALS, NEWBORN; BIOLOGICAL ASSAY; BREAST NEOPLASMS; DIETHYLSTILBESTROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; GENES, REPORTER; HUMAN; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED STRAINS; ORGAN WEIGHT; RECEPTORS, ESTROGEN; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UTERUS; ANIMALS; HUMANS; ORGAN SIZE;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036667358     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/68.2.349     Document Type: Article

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