GSK-3β reduces cAMP-induced cholecystokinin gene expression by inhibiting CREB binding

NeuroReport

Volumn 15, Issue 5, 2004, Pages 841-845

  Hansen, Thomas V O ^a   Rehfeld, Jens F ^a   Nielsen, Finn C ^a  

^a Rigshospitalet   (Denmark)

Author keywords

cAMP; Cholecystokinin; CREB; GSK 3 ; Transcriptional regulation

Indexed keywords

CHOLECYSTOKININ; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; RECOMBINANT ENZYME; SERINE; FORSKOLIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; NEUROBLASTOMA; PHYSIOLOGY; PROTEIN BINDING; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CHOLECYSTOKININ; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DRUG INTERACTIONS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FORSKOLIN; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; NEUROBLASTOMA; PROTEIN BINDING; RATS; TRANSFECTION;

EID: 1842452043     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200404090-00021     Document Type: Article

References (21)

1. Rehfeld JF. The new biology of gastrointestinal hormones. Physiol Rev 78, 1087-1108 (1998).
2. Fink H, Rex A, Voits M and Voigt JP. Major biological actions of CCK - a critical evaluation of research findings. Exp Brain Res 123, 77-83 (1998).
3. Rehfeld JF. Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog. J Biol Chem 253, 4022-4030 (1978).
4. Larsson LI and Rehfeld JF. Localization and molecular heterogeneity of cholecystokinin in the central and peripheral nervous system. Brain Res 165, 201-218 (1979).
5. Hansen TVO and Nielsen FC. Regulation of neuronal cholecystokinin gene transcription. Scand J Clin Lab Invest Suppl 234, 61-67 (2001).
6. Shaywitz AJ and Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68, 821-861 (1999).
7. Fiol CJ, Williams JS, Chou CH, Wang QM, Roach PJ et al. A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem 269, 32187-32193 (1994).
8. Grimes CA and Jope RS. The multifaceted roles of glycogen synthase kinase Sbeta in cellular signaling. Prog Neurobiol 65, 391-426 (2001).
9. Tyson DR, Swarthout JT, Jefcoat SC and Partridge NC. PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Endocrinology 143, 674-682 (2002).
10. Salas TR, Reddy SA, Clifford JL, Davis RJ, Kikuchi A et al. Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei. J Biol Chem 278, 41338-41346 (2003).
11. Bullock BP and Habener JF. Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge. Biochemistry 37, 3795-3809 (1998).
12. Grimes CA and Jope RS. CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium. J Neurochem 78, 1219-1232 (2001).
13. Nielsen FC, Pedersen K, Hansen TVO, Rourke IJ and Rehfeld JF. Transcriptional regulation of the human cholecystokinin gene: composite action of upstream stimulatory factor, Sp1, and members of the CREB/ATF-AP-1 family of transcription factors. DNA Cell Biol 15, 53-63 (1996).
14. Sun P and Maurer RA. An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation. J Biol Chem 270, 7041-7044 (1995).
15. Hansen TVO, Rehfeld JF and Nielsen FC. Mitogen-activated protein kinase and protein kinase A signaling pathways stimulate cholecystokinin transcription via activation of cyclic adenosine 3′,5′-monophosphate response element-binding protein. Mol Endocrinol 13, 466-475 (1999).
16. Hansen TVO, Rehfeld JF and Nielsen FC. Cyclic AMP-induced neuronal differentiation via activation of p38 mitogen-activated protein kinase. J Neurochem 75, 1870-1877 (2000).
17. Monstein HJ, Folkesson R and Geijer T. Procholecystokinin and proenkephalin A mRNA expression is modulated by cyclic AMP and noradrenaline. J Mol Endocrinol 4, 37-41 (1990).
18. De Cesare D, Fimia GM and Sassone-Corsi P. Signaling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem Sci 24, 281-285 (1999).
19. Sanchez JF, Sniderhan LF, Williamson AL, Fan S, Chakraborty-Sett S et al. Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Mol Cell Biol 23, 4649-4662 (2003).
20. Lonze BE, Riccio A, Cohen S and Ginty DD. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34, 371-385 (2002).
21. De Groot RP, den Hertog J, Vandenheede JR, Goris J and Sassone-Corsi P. Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12, 3903-3911 (1993).