Distribution of somatostatin receptor subtypes in rat lumbar spinal cord examined with gold-labelled somatostatin and anti-receptor antibodies

Brain Research

Volumn 816, Issue 1, 1999, Pages 254-257

  Segond Von Banchet, Gisela ^a   Schindler, Marcus ^b   Hervieu, Guillaume J ^c   Beckmann, Barbara ^d   Emson, Piers C ^c   Heppelmann, Bernd ^d  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b GLAXOSMITHKLINE   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Anti sst antibody; Nanogold; Somatostatin gold; Somatostatin receptor subtype

Indexed keywords

RECEPTOR SUBTYPE; SOMATOSTATIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING SITE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUMBAR SPINAL CORD; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

ANIMALS; IMMUNOHISTOCHEMISTRY; LUMBOSACRAL REGION; MALE; MOTOR NEURONS; NERVE FIBERS; RATS; RATS, WISTAR; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; SPINAL CORD;

EID: 0033573717     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01226-8     Document Type: Article

References (29)

1. Bell G., Resine T. Molecular biology of SRIF receptors. Trends Neurosci. 16:1993;34-38.
2. Dalsgaard C.J., Hökfelt T., Johansson O., Elde R. Somatostatin immunoreactive cell bodies in the dorsal horn and the parasympathetic intermediolateral nucleus of the rat spinal cord. Neurosci. Lett. 27:1981;335-339.
3. Hanesch U., Heppelmann B., Schmidt R.F. Somatostatin-like immunoreactivity in primary afferents of the medial articular nerve and colocalization with substance P in the cat. J. Comp. Neurol. 354:1995;345-352.
4. Helmchen C., Fu Q.-G., Sandkühler J. Inhibition of spinal cord nociceptive neurones by microinjections of somatostatin into the nucleus raphe magnus and the midbrain periaqueductal gray of the anaesthetized cat. Neurosci. Lett. 187:1995;137-141.
5. 1) immunoreactivity in the rat brain using an N-terminal specific antibody. Neuroscience. 85:1998;1263-1284.
6. 2) immunoreactivity in the rat central nervous system. Mol. Brain Res. 58:1998;138-155.
7. 1-14 immunoreactivity in primary afferent neurons of the rat spinal cord. Neurosci. Lett. 46:1984;161-166.
8. Hökfelt T., Johansson O., Ljungdahl A., Lundberg J.M., Schultzberg M. Peptidergic neurons. Nature. 284:1980;515-521.
9. Hoyer D. Molecular pharmacology of somatostatin receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 350:1994;441-453.
10. Kar S., Quirion R. Neuropeptide receptors in developing and adult rat spinal cord: an in vitro quantitative autoradiography study of calcitonin gene-related peptide, neurokinins, μ-opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide receptors. J. Comp. Neurol. 354:1995;253-281.
11. Kong H., DePaol A.M., Breder D.D., Yasuda K., Bell G.I., Reisine T. Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain: analysis by RNA blotting and in situ hybridization histochemistry. Neuroscience. 59:1994;175-184.
12. Randic M., Milectic V. Depressant action of M-enkephalin and somatostatin in cat dorsal horn neurons activated by noxious stimuli. Brain Res. 152:1978;196-205.
13. Reisine T., Bell G.I. Molecular properties of somatostatin receptors. Neuroscience. 7:1995;777-790.
14. Reisine T. Somatostatin receptors. Am. J. Physiol. (Gastrointest. Liver Physiol. 32). 269:1995;G813-G820.
15. Rens-Domiano S., Reisine T. Biochemical and functional properties of SRIF receptors. J. Neurochem. 58:1992;1987-1996.
16. Reubi J.C., Maurer R. Autoradiographic mapping of somatostatin receptors in the rat central nervous system and pituitary. Neuroscience. 15:1985;1183-1193.
17. Sandkühler J., Fu Q.-G., Helmchen C. Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: comparison with spinal morphine. Neuroscience. 34:1990;565-576.
18. Sato H., Ota Z., Ogawa N. Somatostatin receptors in the senescent rat brain: a quantitative autoradiographic study. Reg. Peptides. 33:1991;81-92.
19. Schindler M., Humphrey P.P.A., Emson P.C. Somatostatin receptors in the central nervous system. Prog. Neurobiol. 50:1996;9-47.
20. 2(a) receptor in the rat brain and spinal cord. Neuroscience. 76:1997;225-240.
21. Segond von Banchet G., Heppelmann B. Non-radioactive localization of substance P binding sites in rat brain and spinal cord using peptides labelled with 1.4-nm gold particles. J. Histochem. Cytochem. 43:1995;821-827.
22. Segond von Banchet G., Petersen M., Heppelmann B. Bradykinin receptors in cultured rat dorsal root ganglion cells: influence of length of time in culture. Neuroscience. 75:1996;1211-1218.
23. Señaris R.M., Humphrey P.P.A., Emson P.C. Distribution of somatostatin receptor 1, 2 and 3 mRNA in the rat brain and pituitary. Eur. J. Neurosci. 6:1994;1883-1896.
24. Señaris R.M., Schindler M., Humphrey P.P.A., Emson P.C. Expression of somatostatin receptor 3 mRNA in the motorneurones of the rat spinal cord, and the sensory neurones of the spinal ganglia. Mol. Brain Res. 29:1995;185-190.
25. Taura P., Planella V., Balust J., Beltran J., Anglada T., Carrero E., Burgues S. Epidural somatostatin as an analgesic in upper abdominal surgery: a double-blind study. Pain. 59:1994;135-140.
26. Tessler A., Himes B.T., Gruber-Bollinger J., Reichlin S. Characterization of forms of immunoreactive somatostatin in sensory neurons and normal and deafferented spinal cord. Brain Res. 370:1986;232-240.
27. Uhl G.R., Tran V., Snyder S.H., Martin J.B. Somatostatin receptors: distribution in rat central nervous system and human frontal cortex. J. Comp. Neurol. 240:1985;288-304.
28. Wiesenfeld-Hallin Z. Intrathecal somatostatin modulates spinal sensory and reflex mechanisms: behavioural and electrophysiological studies in the rat. Neurosci. Lett. 62:1985;69-74.
29. Wiesenfeld-Hallin Z. Substance P and somatostatin modulate spinal cord excitability via physiologically different sensory pathways. Brain Res. 372:1986;172-175.