The collaborative economy of biotechnology: Alliances, outsourcing and R&D

International Journal of Biotechnology

Volumn 5, Issue 3-4, 2003, Pages 402-438

  Suarez Villa, Luis ^a   Walrod, Wallace ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Res/Commun Orange Co Bus Cncl   (United States)

Author keywords

Alliances; Biotechnology; Collaboration; Innovation; Outsourcing; Research and development

Indexed keywords

INDUSTRIAL ECONOMICS; PATENTS AND INVENTIONS; RESEARCH AND DEVELOPMENT MANAGEMENT;

COLLABORATION;

BIOTECHNOLOGY;

BIOTECHNOLOGY; INNOVATION; RESEARCH AND DEVELOPMENT; SCIENCE AND TECHNOLOGY;

BIOTECHNOLOGY; COST; DRUG INDUSTRY; ECONOMIC ASPECT; EMPIRICISM; EMPLOYMENT; PRACTICE GUIDELINE; RESEARCH; REVIEW;

EID: 1842429545     PISSN: 09636048     EISSN: None     Source Type: Journal    
DOI: 10.1504/ijbt.2003.004104     Document Type: Review

References (94)

1. Acharya, R. (1999) The Emergence and Growth of Biotechnology, Edward Elgar, Northampton, MA.
2. McKelvey, M. (1995) Evolutionary Innovation: the Business of Biotechnology, Oxford University Press, Oxford.
3. Moses, V. and Moses, S. (1995) Exploiting Biotechnology, Harwood Academic, New York.
4. Orsenigo, L., Pammolli, F. and Riccaboni, M. (2001) 'Technological change and network dynamics: lessons from the pharmaceutical industry', Research Policy, Vol. 30, pp.485-508.
5. Russell, A.M. (1988) The Biotechnology Revolution: an International Perspective, St. Martin's, New York.
6. Henderson, R., Orsenigo, L. and Pisano, G.P. (1999) 'The pharmaceutical industry and the revolution in molecular biology: exploring the interactions between scientific institutional and organisational change', in D.C. Mowery and Nelson, R.R. (Eds.) The Sources of Industrial Leadership, Cambridge University Press, Cambridge.
7. Galambos, L. and Sturchio, J.L. (1998) 'Pharmaceutical firms and the transition to biotechnology: a study in strategic innovation', Business History Review, Vol. 72, pp.250-278.
8. Zucker, L.G. and Darby, M.R. (1997) 'Present at the biotechnology revolution: transformation of technological identity for a large incumbent pharmaceutical firm', Research Policy, Vol. 26, pp.429-446.
9. Henderson, R. and Cockburn, I. (1996) 'Scale, scope and spillovers: the determinants of drug productivity in drug discovery', Rand Journal of Economics, Vol. 27, pp.32-59.
10. Ernst and Young, L.L.P. (2000) Convergence: the Biotechnology Industry Report, Ernst and Young, Palo Alto, CA.
11. McCutchen, W.W. and Swamidass, P.M. (1996) 'Exploring larger biotech research firm strategies: projections from a comparison of small and larger firms', Technological Forecasting and Social Change, Vol. 51, pp. 173-184.
12. Grabowski, H. and Vernon, J. (1994) 'Innovation and structural change in pharmaceuticals and biotechnology', Industrial and Corporate Change, Vol. 4, pp.435-449.
13. Lee, K.B. and Burrill, G.S. (1994) Biotech 95: Reform, Restructure, Renewal, Ernst and Young, Palo Alto, CA.
14. Liebeskind, J., Oliver, A., Zucker, L. and Brewer, M. (1996) 'Social networks, learning and flexibility: sourcing scientific knowledge in new biotechnology firms', Organisation Science, Vol. 3, pp.783-831.
15. Powell, W.W., Doput, K.W. and Smith-Doerr, L. (1996) 'Interorganisational collaboration and the locus of innovation: networks of learning in biotechnology', Administrative Science Quarterly, Vol. 41, pp. 116-145.
16. Rosenfeld, S. (1996) 'Does cooperation enhance competitiveness? Assessing the impacts of inter-firm collaboration', Research Policy, Vol. 25, pp.247-263.
17. Arora, A. and Gambardella, A. (1994) 'Evaluating technological information and utilising it: scientific knowledge, technological capability, and external linkages in biotechnology', Journal of Economic Behaviour and Organisation, Vol. 24, pp.91-114.
18. Pisano, G.P. and Mang, P.Y. (1993) 'Collaborative product development and the market for know-how: strategies and structures in the biotechnology industry', in R.A. Burgelman and R.S. Rosenbloom (Eds.) Research on Technological Innovation, Management and Policy, JAI Press, Greenwich, CT.
19. Botkin, J.W. and Matthews, J.B. (1992) Winning Combinations: the Coming Wave of Entrepreneurial Partnerships Between Large and Small Companies, Blenheim, London.
20. Pisano, G.P. (1991) 'The governance of innovation: vertical integration and collaborative arrangements in the biotechnology industry', Research Policy, Vol. 20, pp.237-249.
21. Achilladelis, B. and Antonakis, N. (2001) 'The dynamics of technological innovation: the case of the pharmaceutical industry', Research Policy, Vol. 30, pp.535-588.
22. Henderson, R. (1994) 'The evolution of integrative capabilities: innovation in cardiovascular drug discovery', Industrial and Corporate Change, Vol. 3, pp.607-630.
23. Kenney, M. (1986) Biotechnology: the University-Industrial Complex, Yale University Press, New Haven.
24. Johnson, C. and Moore, R. (1990) 'American universities, technology innovation, and technology transfer: implications for biotechnology research', in D.J. Webber (Ed.) Biotechnology: Assessing Social Impacts and Policy Implications, Greenwood, New York.
25. Lacy, W. and Busch, L. (1989) 'Changing division of labour between the university and industry: the case of agricultural biotechnology', in J. Molnar and J. Kinnucan (Eds.) Biotechnology and the New Agricultural Revolution, Westview, Boulder, CO.
26. Mansfield, E. (1998) 'Academic research and industrial innovation: an update of empirical findings', Research Policy, Vol. 26, pp.773-776.
27. Meyer-Krahmer, F. and Schmoch, U. (1998) 'Science-based technologies: university-industry interaction in four fields', Research Policy, Vol. 27, pp.835-851.
28. Peters, L., Groenewegen, P. and Fiebelkorn, N. (1998) 'A comparison of networks between industry and public sector research in materials technology and biotechnology', Research Policy, Vol. 27, pp.255-271.
29. McMillan, G.S., Narin, F. and Deeds, D.L. (2000) 'An analysis of the critical role of public science in innovation: the case of biotechnology', Research Policy, Vol. 29, pp. 1-8.
30. Orsenigo, L. (1989) The Emergence of Biotechnology, St. Martin's, New York.
31. Audretsch, D.B. and Stephan, P.E. (1996) 'Company-scientist locational links: the case of biotechnology', American Economic Review, Vol. 86, pp.641-652.
32. Zucker, L.G. and Darby, M.R. (1996) 'Costly information: firm transformation, exit, or persistent failure', Behavioural Scientist, Vol. 39, pp.959-974.
33. Barley, S.R., Freeman, J. and Hybels, R.C. (1992) 'Strategic alliances in commercial biotechnology', in N. Nohria and R.G. Eccles (Eds.) Networks and Organisations, Harvard Business School, Boston.
34. Forrest, J.E. and Martin, M.J.C. (1992) 'Strategic alliances between large and small research intensive organisations: experiences in the biotechnology industry', R&D Management, Vol. 22, pp.41-53.
35. Saurez-Villa, L. (2003) www.technocapitalism.com website (10 sections).
36. Gambardella, A. (1995) Science and Innovation: the US Pharmaceutical Industry During the 1980s, Cambridge University Press, Cambridge.
37. Bienz-Tadmor, B. and Brown, J.S. (1994) 'Biopharmaceuticals and conventional drugs: comparing development times', BioPharm, Vol. 7, pp.44-49.
38. DiMasi, J.A., Hansen, R.W., Grabowski, H.G. and Lasagna, L. (1991) 'Cost of innovation in the pharmaceutical industry', PharmacoEconomics, Vol. 7, pp. 152-169.
39. Ernst and Young, L.L.P. (1998) New Directions 98: the Twelfth Biotechnology Industry Annual Report, Ernst and Young, L.L.P, Palo Alto, CA.
40. Oryx Press (various years) BioScan: the Worldwide Biotech Industry Reporting Service, Oryx Press, Phoenix, AZ.
41. Dibner, M. (1991) Biotechnology Guide USA, Macmillan, London.
42. North Carolina Biotechnology Center (1990) State-by-State Biotechnology Directory: Centers, Companies and Contacts, Bureau of National Affairs, Washington, DC.
43. Eddington, S.M. (1994) 'Surviving the '90s: can biotech master clinical trials?' Bio-Technology, Vol. 12, pp.977-981.
44. Saurez-Villa, L. (2002) www.innovativecapacity.com website (9 sections).
45. Saurez-Villa, L. (2003) 'Innovative capacity, networks and the rise of the experimental firm: implications for regional development and policy', paper presented at the International Workshop on Modern Entrepreneurship, Regional Development and Policy: Dynamic and Evolutionary perspectives, Tinbergen Institute, Amsterdam.
46. Gerybadze, A. (1995) Strategic Alliances and Process Redesign: Effective Management and Restructuring of Cooperative Protects and Networks, Walter de Gruyter, Berlin.
47. Badaracco, J. (1991) The Knowledge Link: How Firms Compete Through Strategic Alliances, Harvard Business School Press, Boston.
48. Håkansson, H. (1989) Corporate Technological Behaviour: Co-operation and Networks, Routledge, London.
49. Gates, S. (1993) 'Strategic alliances: guidelines for successful management', Report No. 1028, Conference Board, New York.
50. Limerick, D. and Cunnington, B. (1993) Managing the New Organisation: a Blueprint for Networks and Strategic Alliances, Jossey-Bass, San Francisco.
51. Ring, P. and van de Ven, A. (1992) 'Structuring cooperative relationships between organisations', Strategic Management Journal, Vol. 13, pp.483-498.
52. Lorange, P. and Roos, J. (1991) 'Why some strategic alliances succeed and others fail', Journal of Business Strategy, Vol. 12, pp.25-30.
53. Parkhe, A. (1993) 'Strategic alliance structuring: a game theoretic and transaction cost examination of interfirm cooperation', Academy of Management Journal, Vol. 36, pp.794-829.
54. Suarez-Villa, L. (1998) 'The structures of cooperation: downscaling, outsourcing and the networked alliance', Small Business Economics, Vol, 10, pp.5-16.
55. Hagedoorn, J. (1993) 'Understanding the rationale of strategic technology partnering: interorganisational modes of cooperation and sectoral differences', Strategic Management Journal, Vol. 14, pp.371-385.
56. Segers, J. (1993) 'Strategic partnering between new technology-based firms and large established firms in the biotechnology and microelectronics industries in Belgium', Small Business Economics, Vol. 5, pp.271-281.
57. Borys, B. and Jemison, D. (1989) 'Hybrid arrangements as strategic alliances: theoretical issues in organisational combinations', Academy of Management Review, Vol. 14, pp.234-249.
58. Harrigan, K. (1988) 'Strategic alliances and partner asymmetries', in F. Contractor and P. Lorange (Eds.) Cooperative Strategies in International Business: Joint Ventures and Technology Transfers Between Firms, Lexington Books, New York.
59. Clark, K. (1989) 'Project scope and project performance: the effect of parts strategy and supplier involvement on product development', Management Science, Vol. 35, pp. 1247-1262.
60. Grabher, G. (Ed.) (1993) The Embedded Firm: on the Socioeconomics of Industrial Networks, Routledge, London.
61. Williamson, O.E. (1985) The Economic Institutions of Capitalism: Firms, Markets, and Relational Contracting, Free Press, New York.
62. Becker, C. (1996) 'Trust as non-cognitive security about motives', Ethics, Vol. 107, pp.43-61.
63. Hansen, N.M. (1992) 'Competition, trust and reciprocity in the development of innovative regional milieux', Papers in Regional Science, Vol. 71, pp.95-106.
64. Hardin, R. (1996) 'Trustworthiness', Ethics, Vol. 107, pp.26-42.
65. Misztal, B.A. (1996) Trust in Modern Societies, Polity, Oxford.
66. Cartwright, J. (1991) Unequal Bargaining: a Study of Vitiating Factors in the Formation of Contracts, Clarendon Press, Oxford.
67. Cook, K. and Emerson, R. (1978) 'Power, equity and commitment in exchange relationships', American Sociological Review, Vol. 43, pp.721-739.
68. Gambetta, D. (Ed.) (1988) Trust: Making and Breaking Co-operative Relations, Basil Blackwell. Oxford.
69. Luhmann, N. (1979) Trust and Power, John Wiley, New York.
70. Suarez-Villa, L. and Karlsson, C. (1996) 'The development of Sweden's R&D-intensive electronics industries: exports, outsourcing and territorial distribution', Environment and Planning A, Vol. 28, pp.783-818.
71. Suarez-Villa, L. and Rama, R. (1996) 'Outsourcing, R&D and the pattern of intra-metropolitan location: the electronics industries of Madrid', Urban Studies, Vol. 33, pp.1155-1197.
72. Braun, E. and MacDonald, S. (1982) Revolution in Miniature: the History and Impact of Semiconductor Electronics, Cambridge University Press, Cambridge.
73. Fischer, M.M. (1990) 'The micro-electronic revolution and its impact on labour and employment', in R. Cappellin and P. Nijkamp (Eds.) The Spatial Context of Technological Development, Avebury, Aldershot.
74. Eisenberg, R.S. (1987) 'Proprietary rights and the norms of science in biotechnology research', Yale Law Journal, Vol. 97, pp. 177-231.
75. Ko, Y. (1992) 'An economic analysis of biotechnology patent protection', Yale Law Journal, Vol. 102, pp.777-804.
76. Lerner, J. (1991) 'The impact of patent scope: an empirical examination of new biotechnology firms', CSIA Discussion Paper No. 91-4. Kennedy School of Government, Harvard University, Cambridge, MA.
77. Linck, N.J. and Chambers, S.A. (1995) 'Utility in biotech patent applications', Bio-Technology, Vol. 13, pp.962-964.
78. McGough, K.J. (1995) 'Defining the scope of biotech patent claims', Bio-Technology, Vol. 13, pp.318-319.
79. Sibley, K.D. (1994) The Law and Strategy of Biotechnology Patents, Butterworth-Heinemann, Boston.
80. Dronamraju, K.R. (1998) Biological and Social Issues in Biotechnology Sharing, Ashgate, Brookfield, VT.
81. Joly, P-B. and de Looze, M-A. (1996) 'An analysis of innovation strategies and industrial differentiation through patent applications: the case of plant biotechnology', Research Policy, Vol. 25, pp. 1027-1046.
82. Suarez-Villa, L. (2000) Invention and the Rise of Technocapitalism, Rowman and Littlefield, Lanham, MD.
83. Suarez-Villa, L. (1990) 'Invention, inventive learning, and innovative capacity', Behavioural Science, Vol. 35, pp.290-310.
84. Håkansson, H., Kjelberg, P. and Lundgren, A. (1993) 'Strategic alliances in global biotechnology: a network approach', International Business Review, Vol. 2, pp.65-82.
85. Hamel, G. (1991) 'Competition for competence and interpartner learning within international strategic alliances', Strategic Management Journal, Vol. 12, pp.83-103.
86. Bleeke, J. and Ernst, D. (1993) Collaborating to Compete: Using Strategic Alliances and Acquisitions in the Global Marketplace, John Wiley, New York.
87. Lei, D. and Slocum, J. (1992) 'Global strategy, competence building and strategic alliances', California Management Review, Vol. 34, pp.81-97.
88. Yoshino, M.Y. and Rangan, U.S. (1995) Strategic Alliances: an Entrepreneurial Approach to Globalisation, Harvard Business School Press, Boston.
89. Cooke, P. and Morgan, K. (1998) The Associational Economy, Oxford University Press, Oxford.
90. Malecki, E.J. (1991) Technology and Economic Development, Longman, New York.
91. Suarez-Villa, L. and Walrod, W. (1997) 'Operational strategy, R&D, and intra-metropolitan clustering in a polycentric structure: the advanced electronics industries of the Los Angeles Basin', Urban Studies, Vol. 34, pp. 1343-1380.
92. Suarez-Villa, L. and Fischer, M.M. (1995) 'Technology, organisation and export-driven research and development in Austria's electronics industry', Regional Studies, Vol. 29, pp. 19-42.
93. Dougherty, D.C. (1989) Strategic Organisation Planning: Downsizing for Survival, Quorum, New York.
94. Hoskisson, R.E. and Hitt, M.A. (1994) Downscoping: How to Tame the Diversified Firm, Oxford University Press, New York.