Epstein-Barr Virus-Positive Gastric Carcinoma Has a Distinct Protein Expression Profile in Comparison with Epstein-Barr Virus-Negative Carcinoma

Clinical Cancer Research

Volumn 10, Issue 5, 2004, Pages 1698-1705

  Lee, Hye Seung ^a   Chang, Mee Soo ^a   Yang, Han Kwang ^a   Lee, Byung Lan ^a   Kim, Woo Ho ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CARCINOEMBRYONIC ANTIGEN; CELL NUCLEUS ANTIGEN; DNA; FRAGILE HISTIDINE TRIAD PROTEIN; GENE PRODUCT; LATENT MEMBRANE PROTEIN 1; MUCIN 1; MUCIN 2; MUCIN 5AC; PROTEIN DCC; PROTEIN KAI 1; PROTEIN P16; PROTEIN P53; SMAD4 PROTEIN; SMAD7 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE AMPLIFICATION; GENE CLUSTER; GENE DELETION; GENE EXPRESSION PROFILING; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; ONCOGENE C ERB; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; SEX RATIO; STOMACH CARCINOMA;

BASE SEQUENCE; CLUSTER ANALYSIS; DNA PRIMERS; FEMALE; GENE EXPRESSION PROFILING; HERPESVIRUS 4, HUMAN; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; SEQUENCE DELETION; STOMACH NEOPLASMS; VIRAL MATRIX PROTEINS;

EID: 1842428749     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-1122-3     Document Type: Article

References (30)

1. International Agency for Research on Cancer. Epstein-Barr Virus and Kaposi's Sarcoma Herpesvirus/Human Herpesvirus 8, Vol. 70. Lyon, France: IARC Press, 1997.
2. Shibata, D., and Weiss, L. M. Epstein-Barr virus-associated gastric adenocarcinoma. Am. J. Pathol., 140: 769-774, 1992.
3. Rowlands, D. C., Ito, M., Mangham, D. C., Reynolds, G., Herbst, H., Hallissey, M. T., Fielding, J. W., Newbold, K. M., Jones, E. L., Young, L. S., and Niedobitek, G. Epstein-Barr virus and carcinomas: rare association of the virus with gastric adenocarcinomas. Br. J. Cancer, 68: 1014-1019, 1993.
4. Osato, T., and Imai, S. Epstein-Barr virus and gastric carcinoma. Semin. Cancer Biol., 7: 175-182, 1996.
5. Kang, G. H., Lee, S., Kim, W. H., Lee, H. W., Kim, J. C., Rhyu, M., and Ro, J. Y. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am. J. Pathol., 160: 787-794, 2002.
6. van Rees, B. P., Caspers, E., zur Hausen, A., van den Brule, A., Drillenburg, P., Weterman, M. A., and Offerhaus, G. J. Different pattern of allelic loss in Epstein-Barr virus-positive gastric cancer with emphasis on the p53 tumor suppressor pathway. Am. J. Pathol., 161: 1207-1213, 2002.
7. Chang, M. S., Lee, H. S., Kim, C. W., Kim, Y. I., and Kim, W. H. Clinicopathologic characteristics of Epstein-Barr virus-incorporated gastric cancers in Korea. Pathol. Res. Pract., 197: 395-400, 2001.
8. Chang, M. S., Lee, H. S., Kim, H. S., Kim, S. H., Choi, S. I., Lee, B. L., Kim, C. W., Kim, Y. I., Yang, M., and Kim, W. H. Epstein-Barr virus and microsatellite instability in gastric carcinogenesis. J. Pathol., 199: 447-452, 2003.
9. zur Hausen, A., van Grieken, N. C., Meijer, G. A., Hermsen, M. A., Bloemena, E., Meuwissen, S. G., Baak, J. P., Meijer, C. J., Kuipers, E. J., and van den Brule, A. J. Distinct chromosomal aberrations in Epstein-Barr virus-carrying gastric carcinomas tested by comparative genomic hybridization. Gastroenterology, 121: 612-618, 2001.
10. Kaye, K. M., Izumi, K. M., and Kieff, E. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA, 90: 9150-9154, 1993.
11. Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E., and Rickinson, A. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell, 65: 1107-1115, 1991.
12. Hayashi, K., Chen, W. G., Chen, Y. Y., Murakami, I., Chen, H. L., Ohara, N., Nose, S., Hamaya, K., Matsui, S., Bacchi, M. M., Bacchi, C. E., Chang, K. L., and Weiss, L. M. Deletion of Epstein-Barr virus latent membrane protein 1 gene in Japanese and Brazilian gastric carcinomas, metastatic lesions, and reactive lymphocytes. Am. J. Pathol., 152: 191-198, 1998.
13. Sample, J., Young, L., Martin, B., Chatman, T., Kieff, E., Rickinson. A., and Kieff, E. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. J. Virol., 64: 4084-4092, 1990.
14. Lee, H. S., Lee, H. K., Kim, H. S., Yang, H., and Kim, W. H. Tumor suppressor gene expression correlates with gastric cancer prognosis. J. Pathol., 200: 39-46, 2003.
15. American Joint Committee on Cancer. AJCC Cancer Staging Manual, Ed. 5. Philadelphia: Lippincott-Raven, 1997.
16. Hamilton, S. R., and Aaltonen, L. A. World health organization classification of tumours; tumours of the digestive system. Lyon, France: IARC Press, 2000.
17. Lee, H. S., Lee, H. K., Kim, H. S., Yang, H. K., Kim, Y. I., and Kim, W. H. MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Cancer (Phila.), 92: 1427-1434, 2001.
18. Bouras, T., Southey, M. C., Chang, A. C., Reddel, R. R., Willhite, D., Glynne, R., Henderson, M. A., Armes, J. E., and Venter, D. J. Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Cancer Res., 62: 1289-1295, 2002.
19. Chen, W. G., Chen, Y. Y., Bacchi, M. M., Bacchi, C. E., Alvarenga, M., and Weiss, L. M. Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue. Type A with a high prevalence of deletions within the latent membrane protein gene. Am. J. Pathol., 148: 17-23, 1996.
20. Leoncini, L., Vindigni, C., Megha, T., Funto, I., Pacenti, L., Musaro, M., Renieri, A., Seri, M., Anagnostopoulos, J., and Tosi, P. Epstein-Barr virus and gastric cancer: data and unanswered questions. Int. J. Cancer, 53: 898-901, 1993.
21. Takano, Y., Kato, Y., Saegusa, M., Mori, S., Shiota, M., Masuda, M., Mikami, T., and Okayasu, I. The role of the Epstein-Barr virus in the oncogenesis of EBV(+) gastric carcinomas. Virchows Arch., 434: 17-22, 1999.
22. Tokunaga, M., Land, C. E., Uemura, Y., Tokudome, T., Tanaka, S., and Sato, E. Epstein-Barr virus in gastric carcinoma. Am. J. Pathol., 143: 1250-1254, 1993.
23. Yanai, H., Murakami, T., Yoshiyama, H., Takeuchi, H., Nishikawa, J., Nakamura, H., Okita, K., Miura, O., Shimizu, N., and Takada, K. Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis. J. Clin. Gastroenterol., 29: 39-43, 1999.
24. Schneider, B. G., Gulley, M. L., Eagan, P., Bravo, J. C., Mera, R., and Geradts, J. Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach. Hum. Pathol., 31: 45-50, 2000.
25. Shim, Y. H., Kang, G. H., and Ro, J. Y. Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas. Lab. Investig., 80: 689-695, 2000.
26. Kume, T., Oshima, K., Shinohara, T., Takeo, H., Yamashita, Y., Shirakusa, T., and Kikuchi, M. Low rate of apoptosis and overexpression of bel-2 in Epstein-Barr virus-associated gastric carcinoma. Histopathology, 34: 502-509, 1999.
27. Nishisho, I., Nakamura, Y., Miyoshi, Y., Miki, Y., Ando, H., Horii, A., Koyama, K., Utsunomiya, J., Baba, S., and Hedge, P. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (Wash. DC), 253: 665-669, 1991.
28. Koriyama, C., Akiba, S., Itoh, T., Kijima, Y., Sueyoshi, K., Corvalan, A., Herrera-Goepfer, R., and Eizuru, Y. Prognostic significance of Epstein-Barr virus involvement in gastric carcinoma in Japan. Int. J. Mol. Med., 10: 635-639, 2002.
29. Hu, L. F., Chen, F., Zheng, X., Ernberg, I., Cao, S. L., Christensson, B., Klein, G., and Winberg, G. Clonability and tumorigenicity of human epithelial cells expressing the EBV encoded membrane protein LMPI. Oncogene, 8: 1575-1583, 1993.
30. Knecht, H., Bachmann, E., Brousset, P., Sandvej, K., Nadal, D., Bachmann, F., Odermatt, B. F., Delsol, G., and Pallesen, G. Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma. Blood, 82: 2937-2942, 1993.