Mutagenic Studies on Histidine 98 of Methylglyoxal Synthase: Effects on Mechanism and Conformational Change

Biochemistry

Volumn 43, Issue 13, 2004, Pages 3802-3813

  Marks, Gregory T ^a   Susler, Majelle ^a   Harrison, David H T ^b,c  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DATA ACQUISITION; DEUTERIUM; ENZYME INHIBITION; ENZYME KINETICS; ENZYMES; HYDROGEN BONDS; PHOSPHATES; PHOSPHOLIPIDS; X RAY ANALYSIS;

KINETIC PARAMETERS; METHYLGLYOXAL SYNTHASE (MGS);

MUTAGENESIS;

DEUTERIUM; ENZYME VARIANT; HISTIDINE; METHYLGLYOXAL; METHYLGLYOXAL SYNTHETASE; PHOSPHATE; SYNTHETASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME REGULATION; ENZYME SUBSTRATE; HYDROGEN BOND; ISOMERIZATION; MUTAGENESIS; MUTATION; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT; WILD TYPE; X RAY ANALYSIS;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; ASPARAGINE; CARBON-OXYGEN LYASES; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; DEUTERIUM OXIDE; DIHYDROXYACETONE PHOSPHATE; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; GLUTAMINE; GLYCOLATES; HISTIDINE; HYDROGEN-ION CONCENTRATION; KINETICS; MUTAGENESIS, INSERTIONAL; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 1842426530     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035838o     Document Type: Article

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