Signaling efficiency of the T cell receptor controlled by a single amino acid in the β chain constant region

Journal of Experimental Medicine

Volumn 186, Issue 11, 1997, Pages 1933-1938

  Bäckström, B Thomas ^a   Hausmann, Barbara T ^a   Palmer, Ed ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM IONOPHORE; CD3 ANTIGEN;

AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; HYDROPHOBICITY; IMMUNOGLOBULIN CONSTANT REGION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD3; CALCIUM; IONOPHORES; MAMMALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 1842366740     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.11.1933     Document Type: Article

References (27)

1. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76:263-274.
2. Ashwell, J.D., and R.D. Klausner. 1990. Genetic and mutational analysis of the T-cell antigen receptor. Annu. Rev. Immunol. 8:139-167.
3. Malissen, B., and A.M. Schmitt-Verhulst. 1993. Transmembrane signalling through the T-cell-receptor-CD3 complex. Curr. Opin. Immunol. 5:324-333.
4. Reth, M. 1989. Antigen receptor tail clue. Nature 338:383-384.
5. Chan, A.C., B.A. Irving, J.D. Fraser, and A. Weiss. 1991. The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA. 88:9166-9170.
6. Hatada, M.H., X. Lu, E.R. Laird, J. Green, J.P. Morgenstern, M. Lou, C.S. Marr, T.B. Phillips, M.K. Ram, K. Theriault, et al. 1995. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature. 376: 32-38.
7. Wange, R.L., and L.E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity. 5:197-205.
8. Sciammas, R., Y. Tatsumi, A.I. Sperling, K. Arunan, and J.A. Bluestone. 1994. TCR γδ cells: mysterious cells of the immune system. Immunol. Res. 13:268-279.
9. - T cells. J. Immunol. 140:1107-1110.
10. Salmeron, A., F. Sanchez-Madrid, M.A. Ursa, M. Fresno, and B. Alarcon. 1991. A conformational epitope expressed upon association of CD3-∈ with either CD3-δ or CD3-γ is the main target for recognition by anti-CD3 monoclonal antibodies. J. Immunol. 147:3047-3052.
11. Dave, V.P., Z. Cao, C. Browne, B. Alarcon, G. Fernandex-Miguel, J. Lafaille, A. de la Hera, S. Tonegawa, and D.J. Kappes. 1997. CD3δ deficiency arrests development of the αβ but not the γδ T cell lineage. EMBO (Eur. Mol. Biol. Organ.) J. 16:1360-1370.
12. Correa, I., M. Bix, N.S. Liao, M. Zijlstra, R. Jaenisch, and D. Raulet. 1992. Most γδ T cells develop normally in β 2-microglobulin-deficient mice. Proc. Natl. Acad. Sci. USA. 89:653-657.
13. Bigby, M., J.S. Markowitz, P.A. Bleicher, M.J. Grusby, S. Simha, M. Siebrecht, M. Wagner, C. Nagler-Anderson, and L.H. Glimcher. 1993. Most γδ T cells develop normally in the absence of MHC class II molecules. J. Immunol. 151: 4465-4475.
14. Schweighoffer, E., and B.J. Fowlkes. 1996. Positive selection is not required for thymic maturation of transgenic γδ T cells. J. Exp. Med. 183:2033-2041.
15. Bäckström, B.T., E. Milia, A. Peter, B. Jaureguiberry, C.T. Baldari, and E. Palmer. 1996. A motif within the T cell receptor a chain constant region connecting peptide domain controls antigen responsiveness. Immunity. 5:437-147.
16. DiGiusto, D.L., and E. Palmer. 1994. An analysis of sequence variation in the β chain framework and complementarity determining regions of an allo-reactive T cell receptor. Mol. Immunol. 31:693-699.
17. Letourneur, F., and B. Malissen. 1989. Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α-mRNA of BW5147 origin. Eur. J. Immunol. 19:2269-2274.
18. Lechler, R.I., V. Bal, J.B. Rothbard, R.N. Germain, R. Sekaly, E.O. Long, and J. Lamb. 1988. Structural and functional studies of HLA-DR restricted antigen recognition by human helper T lymphocyte clones by using transfected murine cell lines. J. Immunol. 141:3003-3009.
19. Shimizu, Y., and R. DeMars. 1989. Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line. J. Immunol. 142: 3320-3328.
20. Bäckström, B.T., B. Rubin, A. Peter, G. Tiefenthaler, and E. Palmer. 1997. T cell receptor α-chain tail is required for protein kinase C-mediated down-regulation, but not for signaling. Eur. J. Immunol. 27:1433-1441.
21. Rozdzial, M.M., R.T. Kubo, S.L. Turner, and T.H. Finkel. 1994. Developmental regulation of the TCR ζ-chain. Differential expression and tyrosine phosphorylation of the TCR ζ-chain in resting immature and mature T lymphocytes. J. Immunol. 153:1563-1580.
22. Campbell, K.S., B.T. Bäckström, G. Tiefenthaler, and E. Palmer. 1994. CART: a conserved antigen receptor transmembrane motif. Semin. Immunol. 6:393-410.
23. Rast, J.P., M.K. Anderson, S.J. Strong, C. Luer, R.T. Litman, and G.W. Litman. 1997. α, β, γ, and δ T cell antigen receptor genes arose early in vertebrate phytogeny. Immunity. 6:1-11.
24. Van Neerven, J., J.E. Coligan, and F. Koning. 1990. Structural comparison of α/β and γ/δ T cell receptor-CD3 complexes reveals identical subunit interactions but distinct cross-linking patterns of T cell receptor chains. Eur. J. Immunol. 20: 2105-2111.
25. Garboczi, D.N., P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, and D.C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 [comment]. Nature. 384:134-141.
26. Garcia, K.C., M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton, and I.A. Wilson. 1996. An αβ T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 274:209-219.
27. Kuhlmann, J., S. Caspar-Bauguil, C. Geisler, and B. Rubin. 1993. Characterization of T cell receptor assembly and expression in a Ti γδ-positive cell line. Eur. J. Immunol. 23: 487-493.