Adenovirus-mediated wild-type p53 gene transfer and overexpression induces apoptosis of human glioma cells independent of endogenous p53 status

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 8, 1997, Pages 872-878

  Li, Hewei ^a   Lochmüller, Hanns ^a   Yong, Voon Wee ^a   Karpati, George ^a   Nalbantoglu, Josephine ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Adenoviras; Apoptosis; Gene transfer; Glioma; p53

Indexed keywords

PROTEIN P53; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; ASTROCYTE; CELL VIABILITY; CENTRAL NERVOUS SYSTEM TUMOR; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GLIOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VIRUS RECOMBINANT;

EID: 1842364872     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199708000-00005     Document Type: Article

References (24)

1. Oldfield EH, Ram Z, Culver KW, Blaese RM, DeVroom HL, Anderson WE Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 1993;4:39-69
2. Kleihues P, Soylemezoglu F, Schauble B, Scheithauer BW, Burger PC. Histopathology, classification and grading of gliomas. GLIA 1995;5:211-21
3. Sidransky D, Mikkelsen T, Schwechheimer K, Rosenblum ML, Cavenee WK, Vogelstein B. Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature 1992;355:846-47
4. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 1996;379:88-91
5. Van Meyel DJ, Ramsay DA, Casson AG, Keeney M, Chambers AF, Cairncross JG. p53 mutation, expression, and DNA ploidy in evolving gliomas: Evidence for two pathways of progression. J Natl Cancer Inst 1994;86:1011-17
6. Curtis CC. Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996;88:1442-55
7. Van Meir EG, Roemer K, Diserens AC, et al. Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proc Natl Acad Sci USA 1995;92:1008-12
8. Gomez-Manzano C, Fueyo J, Kyritsis AP, et al. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 1996;56: 694-99
9. Yong VW, Trevor TB, Goodyer CG, Antel JP, Yong F. Differential proliferative response of human and mouse astrocytes to gamma-interferon. GLIA 1992;6:269-80
10. Katayose D, Gudas J, Nguyen H, Srivastava K, Cowan H, Seth P. Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells. Clinical Cancer Res 1995;1:889-97
11. Lochmuller H, Jani A, Huard J, et al. Emergence of early region 1-containing replication-competent adenovirus in stocks of replication-defective adenovirus recombinants (E1+ E3) during multiple passages in 293 cells. Hum Gene Ther 1994;5:1485-91
12. Acsadi G, Jani A, Massie B, et al. A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity. Hum Mol Genet 1994;3:579-84
13. Rosl F. A simple and rapid method for detection of apoptosis in human cells. Nucleic Acids Res 1992;20:5243
14. Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 1992;256:827-30
15. Asai A, Miyagi Y, Sugiyama A, et al. Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. J Neuro-Oncol 1994;19:259-68
16. El-Deiry WS, Tokino VE, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993;75:817-25
17. El-Deiry WS, Harper JW, O'Connor PM, et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 1994; 54:1169-74
18. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993;75:805-16
19. Miyashita T, Krajewski S, Krajewska M, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9:1799-1805
20. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995;80:293-99
21. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell 1994;80:189-92
22. Chen X, Ko LJ, Jayaraman L, Prives C. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 1996;10:2438-51
23. Haupt Y, Powan S, Shaulian E, Vousden KH, Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 1995;9:2170-83
24. Dobner T, Horikoshi N, Rubenwolf S, Shenk T. Blockage by adenovirus E4 orf6 of transcriptional activation by the p53 tumor suppressor. Science 1996;272:1470-73