Lead exposure and (n-3) fatty acid deficiency during rat neonatal development alter liver, plasma, and brain polyunsaturated fatty acid composition

Journal of Nutrition

Volumn 135, Issue 5, 2005, Pages 1027-1033

  Lim, Sun Young ^a   Doherty, John D ^b   Salem Jr , Norman ^c  

^a Korea Maritime University   (South Korea)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

(n 3) fatty acid deficiency; Arachidonic acid; Docosahexaenoic acid; Fatty acid composition; Lead; Pb

Indexed keywords

ACETIC ACID; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; DRINKING WATER; ESSENTIAL FATTY ACID; LEAD;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN LEVEL; BRAIN WEIGHT; CHILDBIRTH; CONTROLLED STUDY; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID ANALYSIS; FEMALE; LACTATION; LIPID COMPOSITION; LIVER; LIVER LEVEL; NONHUMAN; PLASMA; RAT;

EID: 18344385912     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.5.1027     Document Type: Article

References (29)

1. Bernard, S. M. & McGeehin, M. A. (2003) Prevalence of blood lead levels ≤5 μg/dL among US children 1 to 5 years of age and socioeconomic and demographic factors associated with blood of lead levels 5 to 10 μg/dL, Third National Health and Nutrition Examination Survey, 1988-1994. Pediatrics 112: 1308-1313.
2. Lewis, N. M., Widga, A. C., Buck, J. S. & Frederick, A. M. (1995) Survey of omega-3 fatty acids in diets of Midwest low-income pregnant women. J. Agromed. 2: 49-57.
3. Goyer, R. A. (1996) Results of lead research: prenatal exposure and neurological consequences. Environ. Health Perspect. 104: 1050-1054.
4. Cory-Slechta, D. A. (1986) Prolonged lead exposure and fixed ratio performance. Neurobehav. Toxicol. Teratol. 8: 237-244.
5. Cory-Slechta, D. A. & Schaumberg, H. A. (2000) Inorganic lead. In: Experimental and Clinical Neurotoxicology (Spencer, P. S. & Schaumberg, H. A., eds.), pp. 708-719. Oxford University Press, New York, NY.
6. Rice, D. C. (1996) Behavioral effects of lead: commonalities between experimental and epidemiologic data. Environ. Health Perspect. 104 (suppl. 2): 337-351.
7. Kuhlmann, A. C., McGlothan, J. L. & Guilarte, T. R. (1997) Developmental lead exposure causes spatial learning deficits in adult rats. Neurosci. Lett. 233: 101-104.
8. Murphy, K. J. & Regan, C. M. (1999) Low-level lead exposure in the early postnatal period results in persisting neuroplastic deficits associated with memory consolidation. J. Neurochem. 72: 2099-2104.
9. Donaldson, W. E. & Knowles, S. O. (1993) Is lead toxicosis a reflection of altered fatty acid composition of membranes? Comp. Biochem. Physiol C 104: 377-379.
10. Yiin, S. J. & Lin, T. H. (1995) Lead-catalyzed peroxidation of essential unsaturated fatty acid. Biol. Trace Elem. Res. 50: 167-172.
11. Lawton, L. J. & Donaldson, W. E. (1991) Lead-induced tissue fatty acid alterations and lipid peroxidation. Biol. Trace Elem. Res. 28: 83-97.
12. Banks, E. C., Ferretti, L. E. & Shucard, D. W. (1997) Effects of low level lead exposure on cognitive function in children: a review of behavioral, neuropsychological and biological evidence. Neurotoxicology 18: 237-281.
13. Okuyama, H., Kobayashi, T. & Watanabe, S. (1996) Dietary fatty acids-the n-6/n-3 balance and chronic elderly diseases. Excess linoleic acid and relative n-3 deficiency syndrome seen in Japan. Prog. Lipid Res 35: 409-457.
14. Salem, N., Jr., Litman, B., Kim, H. Y. & Gawrisch, K. (2001) Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36: 945-959.
15. Uauy, R., Hoffman, D. R., Mena, P., Llanos, A. & Birch, E. E. (2003) Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. J. Pediatr. 143: S17-S25.
16. Kang, J. X. & Leaf, A. (1996) Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins. Proc. Natl. Acad. Sci. U.S.A. 93: 3542-3546.
17. Chalon, S., Vancassel, S., Zimmer, L., Guilloteau, D. & Durand, G. (2001) Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission. Lipids 36: 937-944.
18. Niu, S. L., Mitchell, D. C., Lim, S. Y., Wen, Z. M., Kim, H. Y., Salem, N., Jr. & Litman, B. J. (2004) Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. J. Biol. Chem. 279: 31098-31104.
19. Lim, S.-Y., Doherty, J., McBride, K., Miller-Ihli, N., Carmona, G., Stark, K. & Salem, N., Jr. (2005) Lead exposure and (n-3) fatty acid deficiency during neonatal development affect subsequent spatial task performance and olfactory discrimination. J. Nutr. 135: 1019-1026.
20. Moriguchi, T., Greiner, R. S. & Salem, N., Jr. (2000) Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J. Neurochem. 75: 2563-2573.
21. Reeves, P. G., Nielsen, F. H. & Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951.
22. Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
23. Morrison, W. R. & Smith, L. M. (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5: 600-608.
24. Salem, N., Jr., Reyzer, M. & Karanian, J. (1996) Losses of arachidonic acid in rat liver after alcohol inhalation. Lipids 31 (suppl.): S153-S156.
25. Zimmermann, L., Pages, N., Antebi, H., Hafi, A., Boudene, C. & Alcindor, L. G. (1993) Lead effect on the oxidation resistance of erythrocyte membrane in rat triton-induced hyperlipidemia. Biol. Trace Elem. Res. 38: 311-318.
26. Donaldson, W. E. & Leeming, T. K. (1984) Dietary lead: effects on hepatic fatty acid composition in chicks. Toxicol. Appl. Pharmacol. 73: 119-123.
27. Knowles, S. O. & Donaldson, W. E. (1996) Dietary lead alters fatty acid composition and membrane peroxidation in chick liver microsomes. Poult. Sci. 75: 1498-1500.
28. Knowles, S. O., Donaldson, W. E. & Andrews, J. E. (1998) Changes in fatty acid composition of lipids from birds, rodents, and preschool children exposed to lead. Biol. Trace Elem. Res. 61: 113-125.
29. Osterode, W. & Ulberth, F. (2000) Increased concentration of arachidonic acid in erythrocyte membranes in chronically lead-exposed men. J. Toxicol. Environ. Health A 59: 87-95.