Antimicrobial peptides in mucosal secretions: The importance of local secretions in mitigating infection

Journal of Nutrition

Volumn 135, Issue 5, 2005, Pages 1289-1293

  Phadke, Shruti M ^a   Deslouches, Berthony ^b   Hileman, Sara E ^b   Montelaro, Ronald C ^a   Wiesenfeld, Harold C ^c   Mietzner, Timothy A ^b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Antibiotic; Antimicrobial peptide; Pseudomonas aeruginosa; Staphylococcus aureus

Indexed keywords

BETA DEFENSIN 1; CASEIN; GLYCOLIPID; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LACTOFERRIN; LACTOPEROXIDASE; LYSOZYME; MILK PROTEIN;

ANTIMICROBIAL ACTIVITY; BACTERIAL INFECTION; BREAST MILK; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; EUKARYOTIC CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; IMMUNOMODULATION; INNATE IMMUNITY; NONHUMAN; PROTEIN DEGRADATION; PSEUDOMONAS AERUGINOSA; SECRETIONS;

EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS 1; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 18344384293     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.5.1289     Document Type: Conference Paper

References (26)

1. Jensen, R. G., ed. (1995) Handbook of Milk Composition. Academic Press, San Diego, CA.
2. Clare, D. A., Catignani, G. L. & Swaisgood, H. E. (2003) Biodefense properties of milk: the role of antimicrobial proteins and peptides. Curr. Pharm. Des. 9: 1239-1255.
3. Ruiz-Palacios, G. M., Cervantes, L. E., Ramos, P., Chavez-Munguia, B. & Newburg, D. S. (2003) Campylobacter jejuni binds intestinal H(O) antigen (Fucα 1,2Gal β 1,4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. J. Biol. Chem. 278: 14112-14120.
4. Isaacs, C. E. (2001) The antimicrobial function of milk lipids. Adv. Nutr. Res. 10: 271-285.
5. Vogel, H. J., Schibli, D. J., Jing, W., Lohmeier-Vogel, E. M., Epand, R. F. & Epand, R. M. (2002) Towards a structure-function analysis of bovine lactoferricin and related tryptophan- and arginine-containing peptides. Biochem. Cell Biol. 80: 49-63.
6. Liepke, C., Adermann, K., Raida, M., Magert, H. J., Forssmann, W. G. & Zucht, H. D. (2002) Human milk provides peptides highly stimulating the growth of bifidobacteria. Eur. J. Biochem. 269: 712-718.
7. Jia, H. P., Starner, T., Ackermann, M., Kirby, P., Tack, B. F. & McCray, P. B., Jr. (2001) Abundant human beta-defensin-1 expression in milk and mammary gland epithelium. J. Pediatr. 138: 109-112.
8. Pellegrini, A. (2003) Antimicrobial peptides from food proteins. Curr. Pharm. Des. 9: 1225-1238.
9. Tencza, S. B., Douglass, J. P., Creighton, D. J., Jr., Montelaro, R. C. & Mietzner, T. A. (1997) Novel antimicrobial peptides derived from human immunodeficiency virus type 1 and other lentivirus transmembrane proteins. Antimicrob. Agents Chemother. 41: 2394-2398.
10. Tencza, S. B., Creighton, D. J., Yuan, T., Vogel, H. J., Montelaro, R. C. & Mietzner, T. A. (1999) Lentivirus-derived antimicrobial peptides: increased potency by sequence engineering and dimerization. J. Antimicrob. Chemother. 44: 33-41.
11. Phadke, S. M., Lazarevic, V., Bahr, C. C., Islam, K., Stolz, D. B., Watkins, S., Tencza, S. B., Vogel, H. J., Montelaro, R. C. & Mietzner, T. A. (2002) Lentivirus lytic peptide 1 perturbs both outer and inner membranes of Serratia marcescens. Antimicrob. Agents Chemother. 46: 2041-2045.
12. Phadke, S. M., Islam, K., Deslouches, B., Kapoor, S. A., Beer Stolz, D., Watkins, S. C., Montelaro, R. C., Pilewski, J. M. & Mietzner, T. A. (2003) Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model. Peptides 24: 1099-1107.
13. Huttner, K. M. & Bevins, C. L. (1999) Antimicrobial peptides as mediators of epithelial host defense. Pediatr. Res. 45: 785-794.
14. Hancock, R. E. (1999) Host defence (cationic) peptides: what is their future clinical potential? Drugs 57: 469-473.
15. Scott, M. G. & Hancock, R. E. (2000) Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit. Rev. Immunol. 20: 407-431.
16. Epand, R. M. & Vogel, H. J. (1999) Diversity of antimicrobial peptides and their mechanisms of action. Biochim. Biophys. Acta 1462: 11-28.
17. Hancock, R. E. & Chapple, D. S. (1999) Peptide antibiotics. Antimicrob. Agents Chemother. 43: 1317-1323.
18. Bals, R., Wang, X., Wu, Z., Freeman, T., Bafna, V., Zasloff, M. & Wilson, J. M. (1998) Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102: 874-880.
19. Scott, M. G., Rosenberger, C. M., Gold, M. R., Finlay, B. B. & Hancock, R. E. (2000) An alpha-helical cationic antimicrobial peptide selectively modulates macrophage responses to lipopolysaccharide and directly alters macrophage gene expression. J. Immunol. 165: 3358-3365.
20. Schibli, D. J., Hwang, P. M. & Vogel, H. J. (1999) Structure of the antimicrobial peptide tritrpticin bound to micelles: a distinct membrane-bound peptide fold. Biochemistry 38: 16749-16755.
21. De Gregorio, E., Spellman, P. T., Tzou, P., Rubin, G. M. & Lemaitre, B. (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J. 21: 2568-2579.
22. Cole, A. M., Ganz, T., Liese, A. M., Burdick, M. D., Liu, L. & Strieter, R. M. (2001) Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J. Immunol. 167: 623-627.
23. Yeaman, M. R. & Yount, N. Y. (2003) Mechanisms of antimicrobial peptide action and resistance. Pharmacol. Rev. 55: 27-55.
24. Gallo, R. L. & Nizet, V. (2003) Endogenous production of antimicrobial peptides in innate immunity and human disease. Curr. Allergy Asthma Rep. 3: 402-409.
25. Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K. & Gallo, R. L. (2001) Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414: 454-457.
26. Nizet, V. & Gallo, R. L. (2002) Surviving innate immunity. Trends Microbiol. 10: 358-359.