Hemodynamic profile of activation of histamine H3 receptors by R-α-methylhistamine in the guinea pig

General Pharmacology

Volumn 27, Issue 6, 1996, Pages 1001-1007

  McLeod, Robbie L ^a   Gertner, Sheldon B ^b   Hey, John A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

atenolol; hemodynamics; hexamethonium; histamine H3 receptors; prazosin; presynaptic inhibition; R methylhistamine; sympathetic neurotransmission

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA METHYLHISTAMINE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; GANGLION BLOCKING AGENT; HEXAMETHONIUM; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR AGONIST; METHACHOLINE; MUSCARINIC AGENT; PRAZOSIN; VERAPAMIL;

ADRENERGIC TRANSMISSION; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CONTROLLED STUDY; DRUG ANTAGONISM; GUINEA PIG; HEART OUTPUT; HEART RATE; HEMODYNAMICS; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; VAGOTOMY; VASCULAR RESISTANCE;

EID: 0030250264     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02110-8     Document Type: Article

References (35)

1. 3) of histamine receptor. Nature 302, 832-837.
2. 2-receptors. Nature 236, 385-390.
3. Brimblecombe R., Owen D. and Parsons M. (1974) The cardiovascular effects of histamine in laboratoy animals. Agents Action 4, 191-192.
4. 3H]-acetylcholine release from slices of rat entorhinal cortex. Br. J. Pharmac. 105, 919-923.
5. 2 antagonists in the monkey. Experientia 32, 1428-1430.
6. 3-agonist is reduced by inhibitors of nitric oxide and prostacyclin synthesis. Br. J. Pharmac. 105, 103-106.
7. 3 agonist decreases arterial blood pressure in the guinea pig. J. Pharmac. 45, 929-931.
8. Furchgott R. (1983) Role of endothelium in responses of vascular smooth muscle. Circ. Res. 53, 557-573.
9. 3-receptors. Br. J. Pharmac. 107, 347-35.
10. Hutchison R. W. and Hey J. A. (1994) Pharmacological characterization of the inhibitory effect of R-α-methylhistamine on sympathetic cardiopressor responses in the pithed guinea pig. J. Auton. Pharmac. 14, 393-402.
11. Holmberg S., Serzysko W. and Varnauskas E. (1971) Coronary circulation during heavy exercise in control subjects and patients with coronary heart disease. Acta Med Scand 190, 465-480.
12. Imamura M., Poli E., Omonyi A. T. and Levi R. (1994) Unmasking of activated histamine receptors in myocardial ischemic: their role as regulators of exocyclotic norepinephrine release. J. Pharmac. Exp. Trer. 221, 1259-1266.
13. 3-receptors in the human heart. Circ. Res. 77, 206-210.
14. 3) of histamine receptor on perivascular nerve terminals. Nature 327, 158-160.
15. Kitamura K., Jorgensen C., Gobel F., Taylor H. and Wang Y. (1972) Hemodynamic correlates of myocardial oxygen consumption during upright exercise. J. Appl. Physiol. 32, 516-522.
16. 3 histamine receptors in guinea pigs by N-α-methylhistamine. Biochem. Biophys. Res. Commun. 168, 979-986.
17. 3 receptors produces presynaptic inhibition of neurally evoked cat nicitating membrane responses in vivo. Naunyn-Schmiedeberg's Pharmac. 346, 208-212.
18. Levi R., Owen D. and Trzeciakowski J. (1982) Actions of histamine on the heart and vasculature. In: Pharmacology of Histamine Receptors (Edited by Ganellin C., Parsons M.), pp. 236-297.
19. 3-receptors inhibit sympathetic neurotransmission in guinea pig myocardium. Eur. J. Pharmac. 204, 311-314.
20. 3 receptor-mediated inhibition of neurogenic vasopressor response in pithed rats. Eur. J. Pharmac. 205, 307-310.
21. 3 receptors in the piked rat. Naosyn-Schniedenberg's Arch. Pharmacol. 347, 55-60.
22. 3 modulation of vagal tone and blood pressure in the conscious guinea pig. Eur. J. Pharmac. 209, 141-142.
23. 3 receptor mediated decrease in basal vascular resistance in guinea pigs. Br. J. Pharmac. 110, 553-558.
24. 3 receptor activation. Eur. J. Pharmac. 259, 211-214.
25. 3 receptors. Naunyn-Schmiedeberg's Pharmac. 346, 46-50.
26. Owens D. (1975) The effects of histamine and some histamine-like agonists on blood pressure in the cat. Br. J. Pharmac. 55, 173-179.
27. Satoh H. and Inui J. (1984) Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery. Eur. J. Pharmac. 97, 321-324.
28. 3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn-Schmiedeberg's Arch. Pharmac. 337, 588-590.
29. 3 receptors. Naunyn-Schmiedeberg's Arch. Pharmac. 340, 633-638.
30. 3 receptor-mediated inhibition of noradrenaline release in pig retina discs. Naunyn-Schmiedeherg's Arch. Pharmac. 324, 497-501.
31. 2 in the vascular action of histamine in dogs. J. Pharmac. Exp. Ther. 223, 257-262.
32. Toda N. (1986) Mechanism of histamine-induced relaxation in isolated monkey and dog coronary arteries. J. Pharmac. Exp. Ther. 239, 529-535.
33. Tsuru H., Kohno S., Iwata M. and Shigei T. (1987) Characterization of histamine receptors in isolated rabbit veins. J. Pharmac. Exp. Ther. 243, 696-702.
34. 2-receptors in pulmonary and systemic vasculature of the dog. Am. J. Physiol. 229, 1008-1013.
35. Zanzinger J., Czachurski J. and Seller H. (1994) Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo. Res. 75, 1073-1077.