Aromatase inhibition by 15-deoxy-prostaglandin J2 (15-dPGJ 2) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production

Journal of Steroid Biochemistry and Molecular Biology

Volumn 94, Issue 1-3 SPEC. ISS., 2005, Pages 159-165

  Andrews, William J ^a   Winnett, Georgia ^a   Rehman, Farah ^a   Shanmugasundaram, Pradeep ^a   Van Hagen, Daphne ^a   Schrey, Michael P ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

15 dPGJ2; 4HPR; Aromatase; Breast cancer; Ceramide

Indexed keywords

15 DEOXYPROSTAGLANDIN J2; ACETYLCYSTEINE; ANTIOXIDANT; AROMATASE; AROMATASE INHIBITOR; CERAMIDE; CERAMIDE DERIVATIVE; FENRETINIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CHORIOCARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MIMICRY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 18244400231     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.01.014     Document Type: Article

References (30)

1. M. Reed The role of aromatase in breast tumours Breast Cancer Res. Treat. 30 1994 7 17
2. W. Miller Aromatase inhibitors and breast cancer Cancer Treat Rev. 23 1997 171 187
3. H. Mouridsen, M. Gershanovich, Y. Sun, R. Perez-Carrion, C. Boni, A. Monnier, J. Apffelstaedt, R. Smith, H. Sleeboom, F. Janicke, A. Pluzanska, M. Dank, D. Becquart, P. Bapsy, E. Salminen, R. Snyder, M. Lassus, J. Verbeek, B. Staffler, H. Chaudri-Ross, and M. Dugan Superior efficacy of letrozole (Femara) versus tamoxifen as first-time therapy for postmenopausal women with advanced breast cancer: results of a phase II study of the International Letrozole Breast Cancer Group J. Clin. Oncol. 19 2001 2596 2606
4. J. Bonneterre, B. Thurlimann, J. Robertson, M. Krzakowski, L. Mauriac, P. Koralewski, I. Vergote, A. Webster, M. Steinberg, and M.v. Euler Anastrazole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the tamoxifen or arimidex randomized group efficacy and tolerability study J. Clin. Oncol. 18 2000 3748 3757
5. M. Baum, A. Budzar, J. Cuzick, J. Forbes, J. Houghton, J. Klijn, T. Sahmoud, and T.A.T. Group Anastrazole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomized trial. The ATAC Trialists' Group Lancet 359 2002 2131 2139
6. H. Ciolino, T. Wang, and N. Sathymoorthy Inhibition of aromatase activity and expression in MCF-7 cells by the chemopreventitive retinoid N-(4-hydroxyphenyl)-retinamide Br. J. Cancer 83 2000 333 337
7. 2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy Int. J. Cancer 103 2003 600 605
8. U. Veronesi, G.D. Palo, E. Marubini, A. Costa, F. Formelli, L. Mariani, A. Decensi, T. Camerini, M.D. Turco, M.D. Mauro, M. Muraca, M.D. Vecchio, C. Pinto, G. D'Aiuto, C. Boni, T. Campa, A. Magni, R. Miceli, M. Perloff, W. Malone, and M. Sporn Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer J. Natl. Cancer Inst. 91 1999 1847 1856
9. N. Oridate, D. Lotan, X. Xu, W. Hong, and R. Lotan Differential induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl) retinamide in human head and neck squamous cell carcinoma cell lines Clin. Cancer Res. 2 1996 855 863
10. C. Zou, J. Kurie, D. Lotan, C. Zou, W. Hong, and R. Lotan Higher potency of N-(4-hydroxyphenyl) retinamide than all-trans-retinoic acid in induction of apoptosis in non-small cell lung cancer cell lines Clin. Cancer Res. 4 1998 1345 1355
11. 2 exerting cell growth inhibition Biochem. Biophys. Res. Commun. 127 1985 739 745
12. 2 induce apoptosis in L1210 cells FEBS Lett. 321 1993 209 214
13. 2 is cytotoxic in human malignancies and synergizes with both cisplatin and radiation Cancer Res. 56 1996 3866 3869
14. C. Clay, A. Namen, G. Atsumi, M. Willingham, K. High, T. Kute, A. Trimboli, A. Fonteh, P. Dawson, and F. Chilton Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells Carcinogenesis 20 1999 1905 1911
15. T. Bui, and D. Straus Effects of cyclopentenone prostaglandins and related compounds on insulin-like growth factor-1 and Waf1 gene expression Biochem. Biophys. Acta 1397 1998 31 42
16. G. Rubin, Y. Zhao, A. Klaus, and E. Simpson Peroxisome proliferator-activated receptor γ ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy Cancer Res. 60 2000 1604 1608
17. S.-Y. Sun, W. Li, Y. Ping, S. Lippman, W. Hong, and R. Lotan Mediation of N-(4-hydroxyphenyl) retinamide-induced apoptosis in human cancer cells by different mechanisms Cancer Res 59 1999 2493 2498
18. B. Spiegelman PPAR-γ: adipogenic regulator and thiazolidinedione receptor Diabetes 47 1998 507 514
19. A.-M. Simeone, S. Ekmekcioglu, L. Broemeling, E. Grimm, and A. Tari A novel mechanism by which N-(4-hydroxyphenyl) retinamide inhibits breast cancer cell growth: the production of nitric oxide Mol. Cancer Ther. 1 2002 1009 1017
20. A. DiPietrantonio, T.-C. Hsieh, S. Olson, and J. Wu Regulation of G1/S transition and induction of apoptosis in HL-60 leukaemia cells by fenretinide (4HPR) Int. J. Cancer 78 1998 53 61
21. N. Andrieu-Abadie, V. Gouaze, R. Salvayre, and T. Levade Ceramide in apoptosis signalling: relationship with oxidative stress Free Radic. Biol. Med. 31 2001 717 728
22. P. Santana, L. Llanes, I. Hernandez, G. Gellardo, J. Quintana, J. Gonzales, F. Estevez, C.R.d. Galarreta, and L. Fanjul Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells Endocrinology 136 1995 2345 2348
23. G. Snyder, R. Holmes, J. Bates, and B.v. Voorhis Nitric oxide inhibits aromatase activity: mechanisms of action J. Steroid Biochem. Mol. Biol. 58 1996 63 69
24. M. Cabot, T.-Y. Han, and A. Giuliano The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation FEBS Lett. 431 1998 185 188
25. 2 in the autocrine control of cell function Int. J. Cancer 67 1996 684 689
26. S. Lim, A. Simeone, C. Kim, A. Tari, and Cyclosporin A enhances the apoptotic effects of N-(4-hydroxyphenyl) retinamide in breast cancer cells Int. J. Cancer 101 2002 243 247
27. B. Maurer, L. Metelista, R. Seeger, M. Cabot, and P. Reynolds Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl) retinamide in neuroblastoma cell lines J. Natl. Cancer Inst. 91 1999 1138 1146
28. E. Simpson, Y. Zhao, V. Agarwal, M. Michael, S. Bulun, M. Hinshelwood, S. Graham-Lorence, T. Sun, C. Fisher, K. Qin, and C. Mendelson Aromatase expression in health and disease Recent Prog. Hormone Res. 52 1997 185 213
29. S. Zhu, H. Li, Y. Wang, Z. Xiao, P. Vikko, and Y. Piao Retinoic acids promote the action of aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17 beta-estradiol in placental cells J. Endocrinol. 172 2002 31 43
30. P. Rauhala, T. Andoh, K. Yeh, and C. Chiueh Contradictory effects of sodium nitroprusside and S-nitroso-N-acetylpencillamine on oxidative stress in brain dopamine neurons in vivo Ann. NY Acad. Sci. 962 2002 60 72