Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response

Journal of Leukocyte Biology

Volumn 77, Issue 5, 2005, Pages 710-718

  Craig Mylius, Kathleen ^a,c   Weber, Georg F ^b,d   Coburn, Jenifer ^b   Glickstein, Lisa ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

IL 12; Macrophage; Mouse; TNF

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; OSTEOPONTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BORRELIA BURGDORFERI; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; HELPER CELL; IN VIVO STUDY; INFLAMMATION; LYME DISEASE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; TH1 CELL;

ANIMALS; BORRELIA BURGDORFERI; CELLS, CULTURED; INTERLEUKIN-12; LYME DISEASE; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOPONTIN; SIALOGLYCOPROTEINS; TARSAL JOINTS; TH1 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BORRELIA; BORRELIA BURGDORFERI;

EID: 18244396334     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0604356     Document Type: Article

References (38)

1. Ashkar, S., Weber, G. F., Panoutsakopoulou, V., Sanchirico, M. E., Jansson, M., Zawaideh, S., Rittling, S. R., Denhardt, D. T., Glimcher, M. J., Cantor, H. (2000) η-1 (Osteopontin): an early component of type-1 (cell-mediated) immunity. Science 287, 860-864.
2. Patarca, R., Freeman, G. J., Singh, R. P., Wei, F. Y., Durfee, T., Blattner, F., Regnier, D. C., Kozak, C. A., Mock, B. A., Morse III, H. C., et al. (1989) Structural and functional studies of the early T lymphocyte activation 1 (η-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J. Exp. Med. 170, 145-161.
3. Nau, G. J., Guilfoile, P., Chupp, G. L., Berman, J. S., Kim, S. J., Kornfeld, H., Young, R. A. (1997) A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proc. Natl. Acad. Sci. USA 94, 6414-6419.
4. Nau, G. J., Liaw, L., Chupp, G. L., Berman, J. S., Hogan, B. L., Young, R. A. (1999) Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. Infect. Immun. 67, 4223-4230.
5. Chabas, D., Baranzini, S. E., Mitchell, D., Bernard, C. C., Rittling, S. R., Denhardt, D. T., Sobel, R. A., Lock, C., Karpuj, M., Pedotti, R., Heller, R., Oksenberg, J. R., Steinman, L. (2001) The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 294, 1731-1735.
6. Lampe, M. A., Patarca, R., Iregui, M. V., Cantor, H. (1991) Polyclonal B cell activation by the η-1 cytokine and the development of systemic autoimmune disease. J. Immunol. 147, 2902-2906.
7. Kang, I., Barthold, S. W., Persing, D. H., Bockenstedt, L. K. (1997) T-helper-cell cytokines in the early evolution of murine Lyme arthritis. Infect. Immun. 65, 3107-3111.
8. Zeidner, N., Mbow, M. L., Dolan, M., Massung, R., Baca, E., Piesman, J. (1997) Effects of Ixodes scapularis and Borrelia burgdorferi on modulation of the host immune response: induction of a TH2 cytokine response in Lyme disease-susceptible (C3H/HeJ) mice but not in disease-resistant (BALB/c) mice. Infect. Immun. 65, 3100-3106.
9. Schoeler, G. B., Manweiler, S. A., Wikel, S. K. (2000) Cytokine responses of C3H/HeN mice infested with Ixodes scapularis or Ixodes pacificus nymphs. Parasite Immunol. 22, 31-40.
10. Wooten, R. M., Ma, Y., Yoder, R. A., Brown, J. P., Weis, J. H., Zachary, J. F., Kirschning, C. J., Weis, J. J. (2002) Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J. Immunol. 168, 348-355.
11. Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W., Carroll, J. D., Espevik, T., Ingalls, R. R., Radolf, J. D., Golenboek, D. T. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274, 33419-33425.
12. Hirschfeld, M., Kirschning, C. J., Schwandner, R., Wesche, H., Weis, J. H., Wooten, R. M., Weis, J. J. (1999) Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2. J. Immunol. 163, 2382-2386.
13. Patarca, R., Saavedra, R. A., Cantor, H. (1993) Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene. Crit. Rev. Immunol. 13, 225-246.
14. Potter, M. R., Rittling, S. R., Denhardt, D. T., Roper, R. J., Weis, J. H., Teuscher, C., Weis, J. J. (2002) Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi. Infect. Immun. 70, 1372-1381.
15. Steere, A. C., Bartenhagen, N. H., Craft, J. E., Hutchinson, G. J., Newman, J. H., Pachner, A. R., Rahn, D. W., Sigal, L. H., Taylor, E., Malawista, S. E. (1986) Clinical manifestations of Lyme disease. Zentralbl. Bakteriol. Mikrobiol. Hyg. [A] 263, 201-205.
16. Barthold, S. W., Beck, D. S., Hansen, G. M., Terwilliger, G. A., Moody, K. D. (1900) Lyme borreliosis in selected strains and ages of laboratory mice. J. Infect. Dis. 162, 133-138.
17. Dong, Z., Edelstein, M. D., Glickstein, L. J. (1997) CD8+ T cells are activated during the early Th1 and Th2 immune responses in a murine Lyme disease model. Infect. Immun. 65, 5334-5337.
18. Keane-Myers, A., Nickell, S. P. (1995) Role of IL-4 and IFN-γ in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 155, 2020-2028.
19. Steere, A. C., Glickstein, L. (2004) Elucidation of Lyme arthritis. Nat. Rev. Immunol. 4, 143-152.
20. Rittling, S. R., Matsumoto, H. N., McKee, M. D., Nanci, A., An, X. R., Novick, K. E., Kowalski, A. J., Noda, M., Denhardt, D. T. (1998) Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J. Bone Miner. Res. 13, 1101-1111.
21. Coburn, J., Leong, J. M., Erban, J. K. (1993) Integrin α IIb β 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets. Proc. Natl. Acad. Sci. USA 90, 7059-7063.
22. Glickstein, L., Edelstein, M., Dong, J. Z. (2001) γ Interferon is not required for arthritis resistance in the murine Lyme disease model. Infect. Immun. 69, 3737-3743.
23. Weis, J. J., McCracken, B. A., Ma, Y., Fairbairn, D., Roper, R. J., Morrison, T. B., Weis, J. H., Zachary, J. F., Doerge, R. W., Teuscher, C. (1999) Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J. Immunol. 162, 948-956.
24. Morrison, T. B., Ma, Y., Weis, J. H., Weis, J. J. (1999) Rapid and sensitive quantification of Borrelia burgdorferi-infected mouse tissues by continuous fluorescent monitoring of PCR. J. Clin. Microbiol. 37, 987-992.
25. Swanson, M. S., Isberg, R. R. (1995) Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect. Immun. 63, 3609-3620.
26. Leong, J. M., Morrissey, P. E., Ortega-Barria, E., Pereira, M. E., Coburn, J. (1995) Hemagglutination and proteoglycan binding by the Lyme disease spirochete. Borrelia burgdorferi. Infect. Immun. 63, 874-883.
27. Baker, G. A. (1946) Distribution of the ratio of sample range to sample standard deviation for normal and combinations of normal distributions. Ann. Mathematical Statistics 17, 366-369.
28. David, H. A., Hartley, H. O., Pearson, E. S. (1954) The distribution of the ratio, in a single normal sample, of range to standard deviation. Biometrika 41, 482-493.
29. Sorensen, E. S., Hojrup, P., Petersen, T. E. (1995) Posttranslational modifications of bovine osteopontin: identification of twenty-eight phosphorylation and three O-glycosylation sites. Protein Sci. 4, 2040-2049.
30. Singh, K., DeVouge, M. W., Mukherjee, B. B. (1990) Physiological properties and differential glycosylation of phosphorylated and nonphosphorylated forms of osteopontin secreted by normal rat kidney cells. J. Biol. Chem. 265, 18696-18701.
31. Stavnezer, J. (1996) Immunoglobulin class switching. Curr. Opin. Immunol. 8, 199-205.
32. Roper, R. J., Weis, J. J., McCracken, B. A., Green, C. B., Ma, Y., Weber, K. S., Fairbairn, D., Butterfield, R. J., Potter, M. R., Zachary, J. F., Doerge, R. W., Teuscher, C. (2001) Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2, 388-397.
33. Saba, S., VanderBrink, B. A., Perides, G., Glickstein, L. J., Link, M. S., Homoud, M. K., Bronson, R. T., Estes III, M., Wang, P. J. (2001) Cardiac conduction abnormalities in a mouse model of Lyme borreliosis. J. Interv. Card. Electrophysiol. 5, 137-143.
34. Armstrong, A. L., Barthold, S. W., Persing, D. H., Beck, D. S. (1992) Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi. Am. J. Trop. Med. Hyg. 47, 249-258.
35. Radolf, J. D., Norgard, M. V., Brandt, M. E., Isaacs, R. D., Thompson, P. A., Beutler, B. (1991) Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct. J. Immunol. 147, 1968-1974.
36. Ma, Y., Seiler, K. P., Tai, K. F., Yang, L., Woods, M., Weis, J. J. (1994) Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway. Infect. Immun. 62, 3663-3671.
37. Infante-Duarte, C., Kamradt, T. (1997) Lipopeptides of Borrelia burgdorferi outer surface proteins induce Th1 phenotype development in αβ T-cell receptor transgenic mice. Infect. Immun. 65, 4094-4099.
38. Brown, J. P., Zachary, J. F., Teuscher, C., Weis, J. J., Wooten, R. M. (1999) Dual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense. Infect. Immun. 67, 142-5150.