Effects of parenterally administered ciprofloxacin in a murine model of pulmonary Pseudomonas aeruginosa infection mimicking ventilator-associated pneumonia

Chemotherapy

Volumn 47, Issue 6, 2001, Pages 421-429

  Kaneko, Yukihiro ^a   Yanagihara, Katsunori ^a   Kuroki, Misuzu ^a   Ohi, Hideo ^a   Kakeya, Hiroshi ^a   Miyazaki, Yoshitsugu ^a   Higashiyama, Yasuhito ^a   Hirakata, Yoichi ^a   Tomono, Kazunori ^a   Kadota, Jun Ichi ^a   Kohno, Shigeru ^a,b  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

Ciprofloxacin; Pseudomonas aeruginosa; Ventilator associated pneumonia

Indexed keywords

CEFOZOPRAN; CILASTATIN PLUS IMIPENEM; CIPROFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG TISSUE LEVEL; HISTOPATHOLOGY; LUNG INFECTION; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

ANIMALS; ANTI-INFECTIVE AGENTS; AREA UNDER CURVE; CEPHALOSPORINS; CILASTATIN; CIPROFLOXACIN; DISEASE MODELS, ANIMAL; IMIPENEM; INFUSIONS, PARENTERAL; MALE; MICE; PNEUMONIA, BACTERIAL; PROTEASE INHIBITORS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATION, ARTIFICIAL; THIENAMYCINS;

EID: 18244390962     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048553     Document Type: Article

References (22)

1. Role of different routes of tracheal colonization in the development of pneumonia in patients receiving mechanical ventilation
2. Mortality due to ventilator-associated pneumonia or colonization with Pseudomonas or Acinetobacter species: Assessment by quantitative culture of samples obtained by a protected specimen brush
3. Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Prospective analysis of 52 episodes with use of a protective specimen brush and quantitative culture techniques
4. Emergence of antibiotic-resistant Pseudomonas aeruginosa: Comparison of risks associated with different antipseudomonal agents
5. HIgh-dose intravenous fluoroquinolones in the treatment of severe infections
6. In vitro and in vivo activities of SCE-2787, a new parenteral cephalosporin with a broad antibacterial spectrum
7. In vitro activity of four fluoroquinolones against clinical isolates of Pseudomonas aeruginosa determined by the E test
8. Clinical and economic evaluation of subsequent infection following intravenous ciprofloxacin or imipenem therapy in hospitalized patients with severe pneumonia
9. Treatment of severe pneumonia in hospitalized patients: Results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin
10. Characterization of an animal model of ventilator-associated pneumonia
11. Elastin fiber analysis in acute diffuse lung injury caused by smoke inhalation
12. Analysis of factors related to the development of ventilator-associated pneumonia: Use of existing databases
13. In vitro and in vivo antibacterial activities of S-4661, a new carbapenem
14. Therapeutic efficacy of cefozopran in a murine model of haematogenous pneumococcal meningitis
15. A new macrolide, TE-031 (A-56268), in treatment of experimental Legionnaires' disease
16. The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration
17. Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose
18. Extravascular penetration of ciprofloxacin. A review
19. Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model
20. Pharmacodynamic activities of ciprofloxacin and spar-floxacin in a murine pneumococcal pneumonia model: Relevance for drug efficacy
21. Comparative activities of ciprofloxacin, ticarcillin, and tobramycin against experimental Pseudomonas aeruginosa pneumonia
22. Comparative efficacy of ciprofloxacin, azlocillin, imipenem/cilastatin and tobramycin in a model of experimental septicemia due to Pseudomonas aeruginosa in neutropenic mice