Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose

Journal of Antimicrobial Chemotherapy

Volumn 43, Issue SUPPL. A, 1999, Pages 43-48

  Birmingham, Mary C ^a   Guarino, Ross ^a   Heller, Allen ^b   Wilton, John H ^a   Shah, Anita ^b   Hejmanowski, Linda ^a   Nix, David E ^a   Schentag, Jerome J ^a  

^a Millard Fillmore Gates Circle Hospital   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; LUNG RESECTION; LUNG SURGERY; MALE;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIPROFLOXACIN; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; LUNG; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 0033008222     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Davis, R., Markham, A. & Balfour, J. A. (1996). Ciprofloxacin. An updated review of its pharmacology, therapeutic efficacy and tolerability. Drugs 51,1019-74.
2. Fink, M. P., Snydman, D. R., Niederman, M. S., Leeper, K. V., Johnson, R. H., Heard, S. O. et al. (1994). Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. Antimicrobial Agents and Chemotherapy 38, 547-57.
3. Forrest, A., Nix, D. E., Ballow, C. H., Goss, T. F., Birmingham, M. C. & Schentag, J. J. (1993). Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrobial Agents and Chemotherapy 37, 1073-81.
4. Nix, D. E., Sands, M. F., Peloquin, C. A., Vari, A. J., Cumbo, T. J., Vance, J. W. et al. (1987). Dual individualization of intravenous ciprofloxacin in patients with nosocomial lower respiratory tract infections. American Journal of Medicine 82, Suppl. 4A, 352-6.
5. Schentag, J. J. (1989). Clinical significance of antibiotic tissue penetration. Clinical Pharmacokinetics 16, Suppl 1., 25-31.
6. Davies, B. I., Maesen, F. P. & Gubbelmans, R. (1989). Azithromycin (CP-62,993) in acute exacerbations of chronic bronchitis: an open clinical, microbiological and pharmacokinetic study. Journal of Antimicrobial Chemotherapy 23, 743-51.
7. Girard, A. E., Girard, D. & Retsema, J. A. (1990). Correlation of the extravascular pharmacokinetics of azithromycin with in-vivo efficacy in models of localized infection. Journal of Antimicrobial Chemotherapy 25, Suppl. A, 61-71.
8. Ritrovato, C. A. & Deeter, R. G. (1991). Respiratory tract penetration of quinolone antimicrobials: a case in study. Pharmacotherapy 11, 38-49.
9. Bergogne-Bérézin, E., Berthelot, G., Even, P., Stern, M. & Reynaud, P. (1986). Penetration of ciprofloxacin into bronchial secretions. European Journal of Clinical Microbiology 5, 197-200.
10. Honeybourne, D., Wise, R. & Andrews, J. M. (1987). Ciprofloxacin penetration into lungs. Lancet i, 1040.
11. Hopf, G., Bocker, R., Estler, C.-J., Radtke, H. J. & Floh, W. (1988). Concentration of ciprofloxacin in human serum, lung and pleural tissues and fluids during and after lung surgery. Infection 16, 29-30.
12. Reid, T. M., Gould, I. M., Golder, D., Legge, J. S., Douglas, J. G., Friend, J. A. et al. (1989). Respiratory tract penetration of ciprofloxacin. American Journal of Medicine 87, Suppl. 5A, 60S-61S.
13. Bacracheva, N., Scholl, H., Gerova, Z., Chervenakov, P., Dobrev, P. & Vlahov, V. (1991). The distribution of ciprofloxacin and its metabolites in human plasma, pulmonary and bronchial tissues. International Journal of Clinical Pharmacology, Therapy, and Toxicology 29, 352-6.
14. Caruso, E., Castro, J. M., Chamoles, N., Galimberti, R., Jorge, L. & Rohwedder, R. (1988). Penetration of ciprofloxacin into human lung tissue after oral and IV dosing. Paper presented at the Sixth Mediterranean Congress of Chemotherapy, Taormina, Italy.
15. Forst, H., Ruckdeschel, G., Unertl, K., Dieterich, H. J., Ehret, W. & Sunder-Plassmann, L. (1989). Lung tissue concentrations of ciprofloxacin following intravenous administration in patients. Arzneimittel-forschung 39, 618-9.
16. Rohwedder, R., Caruso, E., Nunez, T. & Schlecker, H. (1994). Penetration of ciprofloxacin into human respiratory tract tissues after a single intravenous dose of 400 mg ciprofloxacin. In Proceedings of the Sixth International Congress for Infectious Disease, Prague, 1994. Abstract 172. International Society for Infectious Diseases.
17. Lowry, O. H. & Hastings, A. B. (1942). Histochemical changes associated with aging: methods and calculations. Journal of Biological Chemistry 143, 257-69.
18. Neuman, M. (1988). Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clinical Pharmacokinetics 14, 96-121 [and Erratum, ibid. 14(5), table of contents].
19. Baldwin, D. R., Honeybourne, D. & Wise, R. (1992). Pulmonary disposition of antimicrobial agents: methodological considerations. Antimicrobial Agents and Chemotherapy 36, 1171-5.
20. Baldwin, D. R., Wise, R., Andrews, J. M., Gill, M. & Honeybourne, D. (1993). Comparative bronchoalveolar concentrations of ciprofloxacin and lomefloxacin following oral administration. Respiratory Medicine 87, 595-601.