Role of iron in inactivation of epidermal growth factor receptor after asbestos treatment of human lung and pleural target cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 32, Issue 5, 2005, Pages 436-442

  Baldys, Aleksander ^a   Aust, Ann E ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Asbestos; Human lung epithelial cells; Iron

Indexed keywords

AMOSITE; ASBESTOS; CHRYSOTILE; CROCIDOLITE; DEFEROXAMINE; EPIDERMAL GROWTH FACTOR RECEPTOR; IRON; PHYTIC ACID;

ARTICLE; CANCER; CELL LINE; CELL STRAIN A549; CELL STRAIN MET5A; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; LUNG; LUNG ALVEOLUS EPITHELIUM; MESOTHELIUM CELL; PATHOGENESIS; PLEURA; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TARGET CELL;

ASBESTOS; ASBESTOS, CROCIDOLITE; CARCINOGENS; CELL LINE; CYTOCHALASIN B; CYTOCHALASIN D; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; HUMANS; IRON; IRON CHELATING AGENTS; LUNG; MINERAL FIBERS; PHOSPHORYLATION; PHYTIC ACID; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 18244372151     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2004-0133OC     Document Type: Article

References (36)

1. Hardy JA, Aust AE. Iron in asbestos chemistry and carcinogenicity. Chem Rev 1995;95:97-118.
2. Zanella CL, Timblin CR, Cummins A, Jung M, Goldberg J, Raabe R, Tritton TR, Mossman BT. Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis. Am J Physiol 1999;277:L684-L693.
3. Sachsenmaier C, Radler-Pohl A, Zinck R, Nordheim A, Herrlich P, Rahmsdorf HJ. Involvement of growth factor receptors in the mammalian UVC response. Cell 1994;78:963-972.
4. Ravid T, Sweeney C, Gee P, Carraway KL III, Goldkorn T. Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation. J Biol Chem 2002;277:31214-31219.
5. Pache JC, Janssen YM, Walsh ES, Quinlan TR, Zanella CL, Low RB, Taatjes DJ, Mossman BT. Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers. Am J Pathol 1998;152:333-340.
6. Zanella CL, Posada J, Tritton TR, Mossman BT. Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor. Cancer Res 1996;56:5334-5338.
7. Timblin C, Robledo R, Rincon M, Cummins A, Pfeiffer L, Mossman B. Transgenic mouse models to determine the role of epidermal growth factor receptor in epithelial cell proliferation, apoptosis, and asbestosis. Chest 2001;120:22S-24S.
8. Manning CB, Cummins AB, Jung MW, Berlanger I, Timblin CR, Palmer C, Taatjes DJ, Hemenway D, Vacek P, Mossman BT. A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression. Cancer Res 2002;62:4169-4175.
9. Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM, Shawver LK, Arteaga CL. Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. J Biol Chem 2000;275:6987-6995.
10. Park SY, Seol DW. Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis. Biochem Biophys Res Commun 2002;295:515-518.
11. Faux SP, Houghton CE, Hubbard A, Patrick G. Increased expression of epidermal growth factor receptor in rat pleural mesothelial cells correlates with carcinogenicity of mineral fibres. Carcinogenesis 2000;21:2275-2280.
12. Chao CC, Lund LG, Zinn KR, Aust AE. Iron mobilization from crocidolite asbestos by human lung carcinoma cells. Arch Biochem Biophys 1994;314:384-391.
13. Simeonova PP, Wang S, Hulderman T, Luster MI. c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesis. J Biol Chem 2002;277:2945-2950.
14. Chao CC, Aust AE. Effect of long-term removal of iron from asbestos by desferrioxamine B on subsequent mobilization by other chelators and induction of DNA single-strand breaks. Arch Biochem Biophys 1994;308:64-69.
15. 2 redox stress. Am J Respir Cell Mol Biol 1998;19:786-798.
16. Lund LG, Aust AE. Iron mobilization from asbestos by chelators and ascorbic acid. Arch Biochem Biophys 1990;278:61-64.
17. Aljandali A, Pollack H, Yeldandi A, Li Y, Weitzman SA, Kamp DW. Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. J Lab Clin Med 2001;137:330-339.
18. Kamp DW, Panduri V, Weitzman SA, Chandel N. Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Mol Cell Biochem 2002;234-235(1-2):153-160.
19. Panduri V, Weitzman SA, Chandel N, Kamp DW. The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis. Am J Respir Cell Mol Biol 2003;28:241-248.
20. Opresko LK, Chang CP, Will BH, Burke PM, Gill GN, Wiley HS. Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain. J Biol Chem 1995;270:4325-4333.
21. Zhuang S, Ouedraogo GD, Kochevar IE. Downregulation of epidermal growth factor receptor signaling by singlet oxygen through activation of caspase-3 and protein phosphatases. Oncogene 2003;22:4413-4424.
22. Fang R. Induction of ferritin synthesis in human lung epithelial cells (A549) treated with iron-containing particulates and iron mobilization from these particulates: chemistry and biochemistry. Logan: Utah State University; 1999 (dissertation).
23. Smith KR, Veranth JM, Lighty JS, Aust AE. Mobilization of iron from coal fly ash was dependent upon the particle size and the source of coal. Chem Res Toxicol 1998;11:1494-1500.
24. Chao CC, Park SH, Aust AE. Participation of nitric oxide and iron in the oxidation of DNA in asbestos-treated human lung epithelial cells. Arch Biochem Biophys 1996;326:152-157.
25. Smith KR, Veranth JM, Hu AA, Lighty JS, Aust AE. Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal. Chem Res Toxicol 2000;13:118-125.
26. Fung H, Kow YW, Van Houten B, Mossman BT. Patterns of 8-hydroxy-deoxyguanosine formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos. Carcinogenesis 1997;18:825-832.
27. Ball BR. Comparison of glutathione efflux and ferritin induction by iron-containing particles in three types of human lung epithelial cells: chemistry and biochemistry. Logan: Utah State University; 2000. 66 (dissertation).
28. BeruBe KA, Quinlan TR, Fung H, Magae J, Vacek P, Taatjes DJ, Mossman BT. Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos. Am J Respir Cell Mol Biol 1996;15:141-147.
29. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase. Environ Health Perspect 1997;105:1147-1152.
30. Boylan AM, Sanan DA, Sheppard D, Broaddus VC. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5. J Clin Invest 1995;96:1987-2001.
31. Liu W, Ernst JD, Courtney Broaddus V. Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells. Am J Respir Cell Mol Biol 2000;23:371-378.
32. 2. Eur J Biochem 2000;267:1933-1944.
33. 2. Am J Physiol 1997;273:L1029-L1035.
34. Shukla A, Jung M, Stern M, Fukagawa NK, Taatjes DJ, Sawyer D, Van Houten B, Mossman BT. Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis. Am J Physiol Lung Cell Mol Physiol 2003;285:L1018-L1025.
35. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 1996;98:2050-2059.
36. Shukla A, Stern M, Lounsbury KM, Flanders T, Mossman BT. Asbestos-induced apoptosis is protein kinase C delta-dependent. Am J Respir Cell Mol Biol 2003;29:198-205.