Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal

Chemical Research in Toxicology

Volumn 13, Issue 2, 2000, Pages 118-125

  Smith, Kevin R ^a   Veranth, John M ^b   Hu, Autumn A ^b   Lighty, JoAnn S ^b   Aust, Ann E ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b University of Utah   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COAL; INTERLEUKIN 8; IRON;

AIRBORNE PARTICLE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; FLY ASH; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG TOXICITY; PARTICLE SIZE; PARTICULATE MATTER; TOXICOKINETICS;

BIOLOGICAL AVAILABILITY; CARBON; CELL LINE; COAL; DEFEROXAMINE; EPITHELIAL CELLS; FERRIC COMPOUNDS; FERRITINS; HUMANS; INTERLEUKIN-8; IRON; PARTICLE SIZE; PARTICULATE MATTER; PULMONARY ALVEOLI; QUATERNARY AMMONIUM COMPOUNDS; RNA, MESSENGER;

EID: 0034052218     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9901736     Document Type: Article

References (32)

1. Pope, C. A., Bates, D. V., and Raizenne, M. E. (1995) Health effects of particulate air pollution: time for reassessment? Environ. Health Perspect. 103, 472-480.
2. Schwartz, J., Dockery, D. W., and Neas, L. M. (1996) Is daily mortality associated specifically with fine particles? J. Air Waste Manage. Assoc. 46, 927-939.
3. Dockery, D. W., Pope, A. C. I., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., Jr., and Speizer, F. E. (1993) An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 329, 1753-1759.
4. Halliwell, B., and Gutteridge, J. M. C. (1989) Free Radicals in Biology and Medicine, Oxford University Press, Oxford, U.K.
5. Kadiiska, M. B., Mason, R. P., Dreher, K. L., Costa, D. L., and Ghio, A. J. (1997) In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chem. Res. Toxicol. 10, 1104-1108.
6. Pritchard, R. J., Ghio, A. J., Lehmann, J. R., Winsett, D. W., Tepper, J. S., Park, P., Gilmour, M. J., Dreher, K. L., and Costa, D. L. (1996) Oxidant generation and lung injury after particulate air pollutant exposure increase with concentrations of associated metals. Inhalation Toxicol. 8, 457-477.
7. Carter, J. D., Ghio, A. J., Samet, J. M., and Devlin, R. B. (1997) Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. Toxicol. Appl. Pharmacol. 146, 180-188.
8. Mattoli, S., Miante, S., Calabro, F., Mezzetti, M., Fasoli, A., and Allegra, L. (1990) Bronchial epithelial cells exposed to isocyanates potentiate activation and proliferation of T-cells. Am. J. Physiol. 259, L320-L327.
9. Standiford, T. J., Kunkel, S. L., Basha, M. A., Chensue, S. W., Lynch, J. P. I., Toews, G. B., Westwick, J., and Strieter, R. M. (1990) Interleukin-8 gene expression by a pulmonary epithelial cell line. J. Clin. Invest. 86, 1945-1953.
10. Watkinson, W. P., Campen, M. J., and Costa, D. L. (1998) Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension. Toxicol. Sci. 41, 209-216.
11. Vogl, G., and Elstner, E. F. (1989) Diesel soot particles catalyze the production of oxy-radicals. Toxicology Lett. 47, 17-23.
12. Bayram, H., Devalia, J. L., Sapsford, R. J., Ohtoshi, T., Miyabara, Y., Sagai, M., and Davies, R. J. (1998) The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am. J. Respir. Cell Mol. Biol. 18, 441-448.
13. Weitzman, S. A., and Graceffa, P. (1984) Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide. Arch. Biochem. Biophys. 228, 373-376.
14. Aust, A. E., and Lund, L. G. (1991) Iron mobilization from crocidolite results in enhanced iron-catalyzed oxygen consumption and hydroxyl radical generation in the presence of cysteine. In Mechanisms in Fibre Carcinogenesis (Brown, R. C., Hoskins, J. A., and Johnson, N. F., Eds.) pp 397-406, Plenum Press, New York.
15. Weitzman, S. A., and Weitberg, A. B. (1985) Asbestos-catalysed lipid peroxidation and its inhibition by desferroxamine. Biochem. J. 225, 259-262.
16. Gulumian, M., and Kilroe-Smith, T. A. (1987) Crocidolite-induced lipid peroxidation. Environ. Res. 44, 254-259.
17. Fang, R., and Aust, A. E. (1997) Induction of ferritin synthesis in human lung epithelial cells treated with crocidolite asbestos. Arch. Biochem. Biophys. 340, 369-375.
18. Luster, M. I., and Simeonova, P. P. (1998) Asbestos induces inflammatory cytokines in the lung through redox sensitive transcription factors. Toxicol. Lett. 102-103, 271-275.
19. Simeonova, P. P., and Luster, M. I. (1996) Asbestos induction of nuclear transcription factors and interleukin 8 gene regulation. Am. J. Respir. Cell Mol. Biol. 15, 787-795.
20. Rosenthal, G. J., Germolec, D. R., Blazka, M. E., Corsini, E., Simeonova, P., Pollock, P., Kong, L.-Y., Kwon, J., and Luster, M. I. (1994) Asbestos stimulates IL-8 production form human lung epithelial cells. The American Association of Immunologists 153.
21. Smith, K. R., and Aust, A. E. (1997) Mobilization of iron from urban particulates leads to generation of reactive oxygen species in vitro and induction of ferritin synthesis in human lung epithelial cells. Chem. Res. Toxicol. 10, 828-834.
22. Lay, J. C., Bennett, W. D., Ghio, A. J., Bromberg, P. A., Costa, D. L., Kim, C. S., Koren, H. S., and Devlin, R. B. (1999) Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. Am. J. Respir. Cell Mol. Biol. 20, 631-642.
23. Chambers, A. (1999) Coal demand growing: GRI study. Power Eng. 103, 5.
24. Smith, K. R., Veranth, J. M., Lighty, J. S., and Aust, A. E. (1998) Mobilization of iron from coal fly ash was dependent upon the particle size and the source of coal. Chem. Res. Toxicol. 11, 1494-1500.
25. Veranth, J. M., Smith, K. R., Aust, A. E., Dansie, S. L., Griffith, J. B., Hu, A. A., Huggins, M. L., and Lighty, J. S. (2000) Coal fly ash and mineral dust for toxicology and particle characterization studies: Equipment and methods for PM2.5- and PM1-enriched samples. Aerosol Sci. Technol. (in press).
26. Welder, A. A., and Acosta, D. (1994) Enzyme leakage as an indicator of cytotoxicity in cultured cells. In In Vitro Toxicity Indicators (Tyson, C. A., and Frazier, J. M., Eds.) pp 46-49, Academic Press, San Diego.
27. Chao, C.-C., Lund, L. G., Zinn, K. R., and Aust, A. E. (1994) Iron mobilization from crocidolite asbestos by human lung carcinoma cells. Arch. Biochem. Biophys. 314, 384-391.
28. Hornbeck, P. (1994) Antibody-sandwich ELISA to detect soluble antigens. In Current Protocols in Immunology (Coico, R., Coligan, J. E., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M., and Strober, W., Eds.) pp 2.1.9-2.1.11, Wiley, New York.
29. Hansen, L. A., Poulsen, O. M., and Wurtz, H. (1999) Endotoxin potency in the A549 lung epithelial cell bioassay and the limulus amebocyte lysate assay [in process citation]. J. Immunol. Methods 226, 49-58.
30. Ghio, A. J., Stonehuerner, J., Dailey, L. A., and Carter, J. D. (1999) Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress. Inhalation Toxicol. 11, 37-49.
31. Lund, L. G., and Aust, A. E. (1992) Iron mobilization from crocidolite asbestos greatly enhances crocidolite-dependent formation of DNA single-strand-breaks in φX174 RFI DNA. Carcinogenesis 13, 637-642.
32. Takizawa, H., Ohtoshi, T., Kawasaki, S., Kohyama, T., Desaki, M., Kasama, T., Kobayashi, K., Nakahara, K., Yamamoto, K., Matsushima, K., and Kudoh, S. (1999) Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. J. Immunol. 162, 4705-4711.