Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 1, 2002, Pages 51-55

  Boyd, Helen F ^a   Fell, Stephen C M ^a   Hickey, Deirdre M B ^a   Ife, Robert J ^a   Leach, Colin A ^a   Macphee, Colin H ^a   Milliner, Kevin J ^a   Pinto, Ivan L ^a   Rawlings, D Anthony ^a   Smith, Stephen A ^a   Stansfield, Ian G ^a   Stanway, Steven J ^a   Theobald, Colin J ^a   Whittaker, Caroline M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LIPOPROTEIN; PHOSPHOLIPASE A2; PYRIMIDINONE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; HUMAN; NONHUMAN; PLASMA; RABBIT;

ADMINISTRATION, ORAL; ANIMALS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; PHOSPHOLIPASES A; PYRIMIDINONES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244363897     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00678-3     Document Type: Article

References (11)