1-(Arylpiperazinylamidoalkyl)-pyrimidones: Orally active inhibitors of lipoprotein-associated phospholipase A2

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 14, 2001, Pages 1925-1929

  Bloomer, Jackie C ^a   Boyd, Helen F ^a   Hickey, Deirdre M B ^a   Ife, Robert J ^a   Leach, Colin A ^a   Macphee, Colin H ^a   Milliner, Kevin J ^a   Pinto, Ivan L ^a   Rawlings, D Anthony ^a   Smith, Stephen A ^a   Stansfield, Ian G ^a   Stanway, Steven J ^a   Taylor, Maxine A ^a   Theobald, Colin J ^a   Whittaker, Caroline M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2 INHIBITOR; PHENYLPIPERAZINEACETAMIDE DERIVATIVE; PHOSPHOLIPASE A2 INHIBITOR; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; PHYSICAL CHEMISTRY; PLASMA; RABBIT; RAT;

ADMINISTRATION, ORAL; ANIMALS; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; PHOSPHOLIPASES A; PIPERAZINES; PYRIMIDINONES; RABBITS; RATS;

EID: 0035939393     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00346-8     Document Type: Article

References (9)