No increase of apoptosis in regressing mouse liver after withdrawal of growth stimuli or food restriction

Toxicological Sciences

Volumn 85, Issue 1, 2005, Pages 507-514

  Bursch, Wilfried ^a   Wastl, Ute ^a   Hufnagl, Karin ^a   Schulte Hermann, Rolf ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; B6C3F1; C3H He; C57B1 6J; DNA content; DNA synthesis; Liver weight; Nafenopin; Phenobarbital; Protein content

Indexed keywords

DNA; NAFENOPIN; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA CONTENT; DNA SYNTHESIS; FEMALE; FOOD INTAKE; GROWTH STIMULATION; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER DEVELOPMENT; LIVER HYPERTROPHY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; STRAIN DIFFERENCE; TUMOR REGRESSION;

ANIMALS; APOPTOSIS; DNA; FEMALE; FOOD DEPRIVATION; HEPATOMEGALY; LIVER; MALE; MICE; MICE, INBRED STRAINS; NAFENOPIN; ORGAN SIZE; PHENOBARBITAL; PROTEIN BIOSYNTHESIS; SPECIES SPECIFICITY;

EID: 18144386564     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi128     Document Type: Article

References (35)

1. Blommaart, E. F., Luiken, J. J., and Meijer, A. J. (1997). Autophagic proteolysis: Control and specificity. Histochem. J. 29, 365-385.
2. Bursch, W., Lauer, B., Timmermann-Trosiener, I., Barthel, G., Schuppler, J., and Schulte-Hermann, R. (1984). Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5, 453-458.
3. Bursch, W., Chabicovsky, M., Wastl, U., Grasl-Kraupp, B. Bukowska, K., Taper, H., and Schulte-Hermann, R. (2005). Apoptosis in mouse liver with high and low cancer susceptibility: II. Failure of apoptosis to counterbalance cell proliferation in stages of hepatocarcinogenesis and to account for strain differences in tumor susceptibility. Toxicol. Sci. (accompanying manuscript).
4. Chabicovsky, M., Wastl, U., Taper, H., Grasl-Kraupp, B., Schulte-Hermann, R., and Bursch, W. (2003). Induction of apoptosis in mouse liver adenoma and carcinoma in vivo by transforming growth factor-β1. J. Cancer Res. Clin. Oncol. 129, 536-542.
5. Diwan, B. A., Rice, J. M., and Ward, J. M. (1990). Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice. Prog. Clin. Biol. Res. 331, 69-83.
6. Dragani, T. A. (2003). 10 years of mouse cancer modifier loci: Human relevance. Cancer Res. 63, 3011-3018.
7. Fausto, N., (1999). Mouse liver tumorigenesis: Models, mechanisms, and relevance to human disease. Semin. Liver Dis. 19, 243-252.
8. Feo, F., and Pascale, R. M. (1998). Polygenic control of susceptibility and resistance to hepatocarcinogenesis. In Human Polygenic Diseases. Animal Models. (T. A. Dragani, Ed.), pp. 189-216. Harwood Academic Publishers, Amsterdam.
9. Gold, L. S., Slone, T. H., and Ames, B. N. (1998). What do animal cancer tests tell us about human cancer risk?: Overview of analyses of the carcinogenic potency database. Drug Metab. Rev. 30, 359-404.
10. Goldsworthy, T. L., and Fransson-Steen, R. (2002). Quantification of the cancer process in C57B1/6J, B6C3F1 and C3H/HeJ mice. Toxicol. Pathol. 30, 97-105.
11. Grasl-Kraupp, B., Bursch, W., Ruttkay-Nedecky, B., Wagner, A., Lauer, B., and Schulte-Hermann, R. (1994). Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc. Natl. Acad. Sci. USA 91, 9995-9999.
12. Hikita, H., Nuwaysir, E. F., Vaughan, J., Babcock, K., Haas, M. J., Dragan, Y. P., and Pitot, H. C. (1998). The effect of short-term fasting, phenobarbital and refeeding on apoptotic loss, cell replication and gene expression in rat liver during the promotion stage. Carcinogenesis 19, 1417-1425.
13. Huber, W. W., Grasl-Kraupp, B., and Schulte-Hermann, R. (1996). Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk. Crit. Rev. Toxicol. 26, 365-481.
14. James, N. H., and Roberts, R. A. (1996). Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis. Carcinogenesis 17, 1623-1632.
15. James, S. J., and Muskhelishvili, L. (1994). Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6×C3H F1 mice. Cancer Res. 54, 5508-5510.
16. Kamendulis, L. M., Kolaja, K. L., Stevenson, D. E., Walborg, E. F., Jr., and Klaunig, J. E. (2001). Comparative effects of dieldrin on hepatic ploidy, cell proliferation, and apoptosis in rodent liver. J. Toxicol. Environ. Health A.. 62, 127-141.
17. Klaunig, J. E., Babich, M. A., Baetcke, K. P., Cook, J. C., Corton, J. C., David, R. M., DeLuca, J. G., Lai, D. Y., McKee, R. H., Peters, J. M., et al. (2003). PPARalpha agonist-induced rodent tumors: Modes of action and human relevance. Crit. Rev. Toxicol. 33, 655-780.
18. Kolaja, K. L., Bunting, K. A., and Klaunig, J. E. (1996). Inhibition of tumor promotion and hepatocellular growth by dietary restriction in mice. Carcinogenesis 17, 1657-1664.
19. Kanzler, S., and Galle, P. R. (2000). Apoptosis and the liver. Semin. Cancer Biol. 10, 173-184.
20. Maronpot, R. R., Fox, T., Malarkey, D. E., and Goldsworthy, T. L. (1995). Mutations in the ras proto-oncogene: Clues to etiology and molecular pathogenesis of mouse liver tumors. Toxicology 10, 125-156.
21. Oberhammer, F., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A., Bursch, W., and Schulte-Hermann, R. (1992). Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-Fβ1. Proc. Natl. Acad. Sci. U.S.A. 89, 5408-5412.
22. Ogawa, K., Osanai, M., Obata, M., Ishizaki, K., and Kamiya, K. (1999). Gain of chromosomes 15 and 19 is frequent in both mouse hepatocellular carcinoma cell lines and primary tumors, but loss of chromosomes 4 and 12 is detected only in the cell lines Carcinogenesis 20, 2083-2088.
23. Oliver, J. D., and Roberts, R. A. (2002). Receptor-mediated hepatocarcinogenesis: Role of hepatocyte proliferation and apoptosis. Pharmacol. Toxicol. 91,1-7.
24. Parzefall, W., Kainzbauer, E., Hong-Min, Q., Chabicovsky, M., and Schulte-Hermann, R. (2002). Response of isolated hepatocytes from carcinogen sensitive (C3H) and insensitive mice to signals inducing replication or apoptosis. Arch. Toxicol. 76, 699-706.
25. Pearse, A. G. E. (1980). Histochemistry. Theoretical and Applied. Vol. I., 4th ed., p. 146. Churchill Livingstone, London.
26. Poole, T. M., and Drinkwater, N. R. (1996). Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones. Proc. Natl. Acad. Sci. U.S.A. 93, 5848-5853.
27. Sanders, S., and Thorgeirsson, S. S. (2000). Promotion of hepatocarcinogenesis by phenobarbital in e-myc/TGF-alpha transgenic mice. Mol. Carcinog. 28, 168-173.
28. Sarraf, C. E., Horgan, M., Edwards, R. J., and Alison, M. R. (1997). Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice. Int. J. Exp. Pathol. 78, 49-56.
29. Schulte-Hermann, R., Bursch, W., and Grasl-Kraupp, B. (1995). Active cell death (apoptosis) in liver biology and disease. In Progress in Liver Diseases (J. L. Boyer, and R. K. Ockner, Eds.), Vol. XIII, pp. 1-35. W. B. Saunders, Philadelphia.
30. Schulte-Hermann, R., Bursch, W., Gotzman, J. Grasl-Kraupp, B., Mikulits, W., Parzefall, W., Rossmanith, W., and Vejda, S. (2002a). TGF-β induced liver cell apoptosis. In Progress in Gastroenterology and Hepatology (A. M. Gressner, P. C. Heinrich, and S. Matern, Eds.), Proceedings of Falk Symposium 125, Hannover, September 30-October 1, 2001, Part II, pp. 31-43. Kluwer Academic Publishers, London.
31. Schulte-Hermann, R., Bursch, W. Grasl-Kraupp, B., Mikulits, W., Gotzmann, J. Vejda, S., Rossmanith, W., and Parzefall, W. (2002b). Apoptotic cytokines as regulators of anti-oncogenic responses and hepatocellular carcinoma growth. In Immunology and the Liver.- Cytokines. (R. Moreno-Otreo, A. Albillos, and C. García-Monzón, Eds.; G. Castellano, G. Clemente, and V. Cuervas-Mons, Co-Eds.), pp. 281-290. Association Liver Hígado de Investigacíon Científica (ALHIC), Madrid. Accion Médica, S.A.
32. Stevenson, D. E., Walborg, E. F. Jr., North, D. W., Sielken, R. L. Jr., Ross, C. E., Wright, A. S., Xu, Y., Kamendulis, L. M. and Klaunig, J. E. (1999). Monograph: Reassessment of human cancer risk of aldiin/dieldrin. Toxicol. Lett. 109, 123-186.
33. Takahashi, M., Dinse, G. E., Foley, J. F., Hardisty, J. F., Maronpot, R. R. (2002). Comparative prevalence, multiplicity, and progression of spontaneous and vinyl carbamate-induced liver lesions in five strains of male mice. Toxicol. Pathol. 30, 599-605.
34. Tomasi, C., Laconi, E., Laconi, S., Greco, M., Sarma, D. S., and Pani, P. (1999). Effect of fasting/refeeding on the incidence of chemically induced hepatocellular carcinoma in the rat. Carcinogenesis 20, 1979-1983.
35. Whysner, J., Ross, P. M., and Williams, G. M. (1996). Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 71, 153-191.