Response of isolated hepatocytes from carcinogen sensitive (C3H) and insensitive (C57BL) mice to signals inducing replication or apoptosis

Archives of Toxicology

Volumn 76, Issue 12, 2002, Pages 699-706

  Parzefall, Wolfram ^a   Kainzbauer, Eveline ^a   Qin, Hong Min ^a   Chabicovsky, Monika ^a   Schulte Hermann, Rolf ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Carcinogenesis; DNA synthesis; Epidermal growth factor; Mouse; Rat; Short term culture; Transforming growth factor 1

Indexed keywords

CANCER GROWTH FACTOR; CARCINOGEN; EPIDERMAL GROWTH FACTOR; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL ISOLATION; CLINICAL PROTOCOL; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; GENE REPLICATION; HUMAN; LIVER CELL; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; ANIMAL; CARCINOGEN TESTING; COMPARATIVE STUDY; DNA REPLICATION; DOSE RESPONSE; DRUG EFFECT; PATHOLOGY; SPECIES DIFFERENCE;

ANIMALIA;

ANIMALS; APOPTOSIS; CARCINOGENICITY TESTS; CELLS, CULTURED; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMAL GROWTH FACTOR; HEPATOCYTES; MALE; MICE; MICE, INBRED STRAINS; SPECIES SPECIFICITY; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0036451609     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0397-8     Document Type: Article

References (51)

1. Andervont HB (1950) Studies on the occurrence of spontaneous hepatomas in mice strains C3H and CBA. J Natl Cancer Inst 11:581-592
2. Becker FF (1985) Tumor phenotype and susceptibility to progression as an expression of subpopulations of initiated murine cells. Cancer Res 45:768-773
3. Bucher NLR, Patel U, Cohen S (1978) Hormonal factors and liver growth. Adv Enzyme Regul 16:205-213
4. Buchmann A, Bauerhofmann R, Mahr J, Drinkwater NR, Luz A, Schwarz M (1991) Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains - Correlation with susceptibility to hepatocarcinogenesis. Proc Natl Acad Sci U S A 88:911-915
5. Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R (1984) Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5:453-458
6. Bursch W, Paffe S, Putz B, Barthel G, Schulte-Hermann R (1990) Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis 11:847-853
7. Carr BI, Hayashi I, Branum EL, Moses HL (1986) Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type β transforming growth factor. Cancer Res 46:2330-2334
8. Counts JL, Kaznowski JM, McClain RM, Goodman JI (1997) 5-Methylcytosine is present in the 5′ flanking region of Ha-ras in mouse liver and increases with ageing. Int J Cancer 72:491-497
9. Diwan BA, Rice JM, Ohshima M, Ward JM (1986) Interstrain differences in susceptibility to liver carcinogenesis initiated by n-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice. Carcinogenesis 7:215-220
10. Diwan BA, Rice JM, Ward JM (1990) Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice. Mouse Liver Carcinog 331:69-83
11. Drinkwater NR, Ginsler JJ (1986) Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice. Carcinogenesis 7:1701-1707
12. Drinkwater NR, Hanigan MH, Kemp CJ (1989) Genetic determinants of hepatocarcinogenesis in the B6C3F1 mouse. Toxicol Lett 49:255-265
13. Dunnett SW (1955) A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50:1096-1121
14. Edwards AM, Lucas CM (1985) Phenobarbital and some other liver tumor promotors stimulate DNA synthesis in cultured rat hepatocytes. Biochem Biophys Res Comm 131:103-108
15. Frey S, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M (2000) Suppression of apoptosis in C3H mouse liver tumors by activated Ha-ras oncogene. Carcinogenesis 21:161-166
16. Gold LS, Zeiger E (1997) Handbook of Carcinogenic Potency and Genotoxicity Databases. Boca Raton
17. Gold LS, Slone TH, Manley NB, Bernstein L (1991) Target organs in chronic bioassays of 533 chemical carcinogens. Environ Health Perspect 93:233-246
18. Goldsworthy TL, Fransson-Steen R (2002) Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice. Toxicol Pathol 30:97-105
19. Goldsworthy TL, Conolly RB, Fransson-Steen R (1996) Apoptosis and cancer risk assessment. Mutat Res 365:71-90
20. Grasso P, Hardy J (1975) Strain difference in natural incidence and response to carcinogens. In: Butler WH, Newberne PM (eds) Mouse Hepatic Neoplasia. Elsevier, New York, pp 111-131
21. Hanigan MH, Kemp CJ, Ginsler JJ, Drinkwater NR (1988) Rapid growth of preneoplastic lesions in hepatocarcinogen-sensitive C3H/HeJ male mice relative to C57Bl/6J male mice. Carcinogenesis 9:885-890
22. Kobusch A-B, Bock KW (1990) Zinc increases EGF-stimulated DNA synthesis in primary mouse hepatocytes studies in tumor promoter-treated cell cultures. Biochem Pharmacol 39:555-558
23. Kumar V, Bustin SA, McKay IA (1995) Transforming growth factor alpha. Cell Biol Int 19:373-388
24. Labarca C, Paigen K (1980) A simple rapid and sensitive DNA assay procedure. Anal Biochem 102:344-352
25. Manenti G, Binelli G, Gariboldi M, Canzian F, De Gregorio L, Falvella FS, Dragani TA, Pierotti MA (1994) Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice. Genomics 23:118-124
26. McGowan JA, Strain AJ, Bucher NLR (1981) DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of EGF, insulin, glucagon, and cyclic-amp. J Cell Physiol 108:353-363
27. Michalopoulos G, Sattler CA, Sattler GL, Pitot HC (1976) Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes. Science 193:907-909
28. Michalopoulos G, Cianciulli HD, Novotny AR, Kligerman AD, Strom SC, Jirtle RL (1982) Liver regeneration studies with rat hepatocytes in primary culture. Cancer Res 42:4673-4682
29. Moolgavkar S, Krewski D, Schwarz M (1999) Mechanisms of carcinogenesis and biologically based models for estimation and prediction of risk. IARC Sci Publ 131:179-237
30. Nakamura T, Tomita Y, Hirai R, Ichihara A (1985) Inhibitory effect of transforming growth factor-beta on DNA synthesis of adult rat hepatocytes in primary culture. Biochem Biophys Res Comm 133:1042-1050
31. Oberhammer FA, Bursch W, Parzefall W, Breit P, Erber E, Stadler M, Schulte-Hermann R (1991) E3ect of transforming growth factor-beta on cell death of cultured rat hepatocytes. Cancer Res 51:2478-2485
32. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-beta1. Proc Nat Acad Sci USA 89:5408-5412
33. Parzefall W, Galle PR, Schulte-Hermann R (1982) Studies on the induction of cell replication by liver tumor promoters in primary cultures of adult rat hepatocytes. Naunyn Schmiedebergs Arch Pharmacol 321:R29
34. Parzefall W, Galle PR, Schulte-Hermann R (1985) Effect of calf and rat serum on the induction of DNA synthesis and mitosis in primary cultures of adult rat hepatocytes by cyproterone acetate and epidermal growth factor. In Vitro Cell Dev Biol 21:665-673
35. Parzefall W, Monschau P, Schulte-Hermann R (1989) Induction by cyproterone acetate of DNA synthesis and mitosis in primary cultures of adult rat hepatocytes in serum free medium. Arch Toxicol 63:456-461
36. Parzefall W, Erber E, Sedivy R, Schulte-Hermann R (1991) Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters. Cancer Res 51:1143-1147
37. Parzefall W, Erber E, Kainzbauer E, Schulte-Hermann R (1996) Effects of insulin, glucagon and triiodothyronine on DNA synthesis in rat hepatocyte primary cultures induced by liver tumour promoters and EGF. Toxicol In Vitro 10:183-193
38. Petersen B, Yee CJ, Bowen W, Zarnegar B, Michalopoulos GK (1994) Distinct morphological and mito-inhibitory effects induced by TGF-β1, HGF and EGF on mouse, rat and human hepatocytes. Cell Biol Toxicol 10:219-230
39. Qiao L, Farrell GC (1999) The effects of cell density, attachment substratum and dexamethasone on spontaneous apoptosis of rat hepatocytes in primary culture. In Vitro Cell Dev Biol 35:417-424
40. Richman RA, Claus TH, Pilkis SJ, Friedman DL (1976) Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes. Proc Nat Acad Sci U S A 73:3589-3593
41. Russell WE (1988) Transforming growth factor beta (TGF-beta) inhibits hepatocyte DNA synthesis independently of EGF binding and EGF receptor autophosphorylation. J Cell Physiol 135:253-261
42. Santoni-Rugiu E, Jensen MR, Thorgeirsson SS (1998) Disruption of the PRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Cancer Res 58:123-134
43. Schulte-Hermann R, Bursch W, Kraupp-Grasl B, Oberhammer F, Wagner A, Jirtle R (1993) Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environ Health Perspect 101:87-90
44. Schulte-Hermann R, Bursch W, Grasl-Kraupp B (1995) Active cell death (apoptosis) in liver biology and disease. Prog Liver Dis 13:1-35
45. Schulte-Hermann R, Bursch W, Gotzmann J, Grasl-Kraupp B, Mikulits W, Parzefall W, Rossmanith W, Vejda S (2002) TGF-β-induced liver cell apoptosis. In: Gressner AM, Heinrich PC, Matern S (eds) Cytokines in Liver Injury and Repair, vol. 125. Kluwer Academic Publishers, Dordrecht, The Netherlands, pp 31-42
46. Seglen OP (1976) Preparation of isolated rat liver cells. In: Prescott DM (ed) Methods in Cell Biology, vol. XIII. Academic Press, New York, pp 29-81
47. Selkirk JK, Soward SM (1993) Compendium of abstracts from long-term cancer studies reported by the National Toxicology Program of the National Institute of Environmental Health Sciences from 1976 to 1992. Environ Health Perspect 101 [Suppl 1]:1-295
48. Vorce RL, Goodman JI (1991) Differential DNAse I hypersensitivity of ras oncogenes in B6C3f1, C3H/he, and C57BL/6 mouse liver. J Toxicol Environ Health 34:385-395
49. Ward JM, Shibata M, Devor DE (1996) Emerging issues in mouse liver carcinogenesis. Toxicol Pathol 24:129-137
50. Wastl UM (1997) Liver Growth and Regression after Short-term Treatment with Tumor Promoters(Phenobarbital, Nafenopin) in Mouse Strains with Different Susceptibility to Hepatocarcinogenesis. Thesis, Vienna
51. Yoshie M, Nishimori H, Lee GH, Ogawa K (1998) High colony forming capacity of primary cultured hepatocytes as a dominant trait in hepatocarcinogenesis-susceptible and resistant mouse strains. Carcinogenesis 19:1103-1107