The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder

Biological Psychiatry

Volumn 57, Issue 10, 2005, Pages 1097-1102

  Hashimoto, Ryota ^a   Okada, Takeya ^a   Kato, Tadafumi ^d   Kosuga, Asako ^b   Tatsumi, Masahiko ^c,e   Kamijima, Kunitoshi ^c   Kunugi, Hiroshi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^e Yokohama Shinryo Clinic   (Japan)

Author keywords

22q; Association study; Bipolar disorder; Breakpoint cluster region (BCR); Major depression; Single nucleotide polymorphism (SNP)

Indexed keywords

RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; BIPOLAR DISORDER; BREAKPOINT CLUSTER REGION GENE; CHROMOSOME 22Q; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 18144381571     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.02.019     Document Type: Article

References (37)

1. M. Amano, K. Chihara, K. Kimura, Y. Fukata, N. Nakamura, Y. Matsuura Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase Science 275 1997 1308 1311
2. J.A. Badner, E.S. Gershon Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia Mol Psychiatry 7 2002 405 411
3. G. Chen, G. Rajkowska, F. Du, N. Seraji-Bozorgzad, H.K. Manji Enhancement of hippocampal neurogenesis by lithium J Neurochem 75 2000 1729 1734
4. W. Coryell, J. Endicott, T. Reich, N. Andreasen, M. Keller A family study of bipolar II disorder Br J Psychiatry 145 1984 49 54
5. S.D. Detera-Wadleigh, J.A. Badner, W.H. Berrettini, T. Yoshikawa, L.R. Goldin, G. Turner A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2 Proc Natl Acad Sci U S A 96 1999 5604 5609
6. D. Diekmann, S. Brill, M.D. Garrett, N. Totty, J. Hsuan, C. Monfries Bcr encodes a GTPase-activating protein for p21rac Nature 351 1991 400 402
7. H.J. Edenberg, T. Foroud, P.M. Conneally, J.J. Sorbel, K. Carr, C. Crose Initial genomic scan of the NIMH genetics initiative bipolar pedigrees chromosomes 3, 5, 15, 16, 17, and 22 Am J Med Genet 74 1997 238 246
8. S. Etienne-Manneville, A. Hall Rho GTPases in cell biology Nature 420 2002 629 635
9. T. Fioretos, J.W. Voncken, T.Z. Baram, F. Kamme, J. Groffen, N. Heisterkamp Regional localization and developmental expression of the BCR gene in rodent brain Cell Mol Biol Res 41 1995 97 102
10. S.B. Gabriel, S.F. Schaffner, H. Nguyen, J.M. Moore, J. Roy, B. Blumenstiel The structure of haplotype blocks in the human genome Science 296 2002 2225 2229
11. P. Good Permutation tests A practical guide to resampling methods for testing hypothesis Second edition ed 2000 Springer-Verlag New York
12. L.M. Hallcher, W.R. Sherman The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain J Biol Chem 255 1980 10896 10901
13. R. Hashimoto, C. Hough, T. Nakazawa, T. Yamamoto, D.M. Chuang Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation J Neurochem 80 2002 589 597
14. R. Hashimoto, Y. Nakamura, H. Goto, Y. Wada, S. Sakoda, K. Kaibuchi Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase Biochem Biophys Res Commun 245 1998 407 411
15. R. Hashimoto, V. Senatorov, H. Kanai, P. Leeds, D.M. Chuang Lithium stimulates progenitor proliferation in cultured brain neurons Neuroscience 117 2003 55 61
16. R. Hashimoto, N. Takei, K. Shimazu, L. Christ, B. Lu, D.M. Chuang Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons an essential step for neuroprotection against glutamate excitotoxicity Neuropharmacology 43 2002 1173 1179
17. R. Hashimoto, M. Yoshida, N. Ozaki, Y. Yamanouchi, N. Iwata, T. Suzuki Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia J Neural Transm 111 2004 217 221
18. R. Hashimoto, M. Yoshida, N. Ozaki, Y. Yamanouchi, N. Iwata, T. Suzuki A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men Schizophr Res 73 2005 383 385
19. A.B. Huber, A.L. Kolodkin, D.D. Ginty, J.F. Cloutier Signaling at the growth cone ligand-receptor complexes and the control of axon growth and guidance Annu Rev Neurosci 26 2003 509 563
20. K. Kaibuchi, S. Kuroda, M. Amano Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells Annu Rev Biochem 68 1999 459 486
21. C. Kakiuchi, K. Iwamoto, M. Ishiwata, M. Bundo, T. Kasahara, I. Kusumi Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder Nat Genet 35 2003 171 175
22. J.R. Kelsoe Arguments for the genetic basis of the bipolar spectrum J Affect Disord 73 2003 183 197
23. J.R. Kelsoe, M.A. Spence, E. Loetscher, M. Foguet, A.D. Sadovnick, R.A. Remick A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22 Proc Natl Acad Sci U S A 98 2001 585 590
24. P.S. Klein, D.A. Melton A molecular mechanism for the effect of lithium on development Proc Natl Acad Sci U S A 93 1996 8455 8459
25. M. Korus, G.M. Mahon, L. Cheng, I.P. Whitehead p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr Oncogene 21 2002 4601 4612
26. H. Kosako, M. Amano, M. Yanagida, K. Tanabe, Y. Nishi, K. Kaibuchi Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase J Biol Chem 272 1997 10333 10336
27. M.A. Lemmon, K.M. Ferguson, C.S. Abrams Pleckstrin homology domains and the cytoskeleton FEBS Lett 513 2002 71 76
28. Y. Maru, O.N. Witte The BCR gene encodes a novel serine/threonine kinase activity within a single exon Cell 67 1991 459 468
29. M. Negishi, H. Katoh Rho family GTPases as key regulators for neuronal network formation J Biochem (Tokyo) 132 2002 157 166
30. F. Pane, M. Intrieri, C. Quintarelli, B. Izzo, G.C. Muccioli, F. Salvatore BCR/ABL genes and leukemic phenotype from molecular mechanisms to clinical correlations Oncogene 21 2002 8652 8667
31. J.K. Pritchard, M. Stephens, P. Donnelly Inference of population structure using multilocus genotype data Genetics 155 2000 945 959
32. H. Shimon, G. Agam, R.H. Belmaker, T.M. Hyde, J.E. Kleinman Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder Am J Psychiatry 154 1997 1148 1150
33. J.C. Soares, A.G. Mallinger Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients Psychopharmacol Bull 33 1997 685 691
34. G. Turecki, P. Grof, E. Grof, V. D'Souza, L. Lebuis, C. Marineau Mapping susceptibility genes for bipolar disorder a pharmacogenetic approach based on excellent response to lithium Mol Psychiatry 6 2001 570 578
35. E. Vieta, C. Gasto, A. Otero, E. Nieto, J. Vallejo Differential features between bipolar I and bipolar II disorder Compr Psychiatry 38 1997 98 101
36. R.S. Williams, L. Cheng, A.W. Mudge, A.J. Harwood A common mechanism of action for three mood-stabilizing drugs Nature 417 2002 292 295
37. K. Yamada, K. Nakamura, Y. Minabe, Y. Iwayama-Shigeno, H. Takao, T. Toyota Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts Biol Psychiatry 56 2004 683 690