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Volumn 33, Issue 4, 1997, Pages 685-691

Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients

Author keywords

Bipolar disorder; Pathophysiology; Phosphoinositides; Second messengers; Signal transduction

Indexed keywords

CALCIUM ION; INOSITOL; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL; PROTEIN KINASE C;

EID: 0031405823     PISSN: 00485764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (52)

References (78)
  • 1
    • 0024581924 scopus 로고
    • Inositol-1-phosphatase of human erythrocytes is inhibited by therapeutic lithium concentrations
    • Agam, G, and Livne, A. Inositol-1-phosphatase of human erythrocytes is inhibited by therapeutic lithium concentrations. Psychiatry Res. 27:217-224, 1989.
    • (1989) Psychiatry Res. , vol.27 , pp. 217-224
    • Agam, G.1    Livne, A.2
  • 2
    • 0029012464 scopus 로고
    • Inositol monophosphatase inhibitors: A novel treatment for bipolar disorder?
    • Atack, JR. Inositol monophosphatase inhibitors: A novel treatment for bipolar disorder? Biol. Psychiatry 37:761-763, 1995.
    • (1995) Biol. Psychiatry , vol.37 , pp. 761-763
    • Atack, J.R.1
  • 3
    • 0344600285 scopus 로고    scopus 로고
    • Are platelet and magnetic resonance spectroscopic changes indicative of altered PI signalling in bipolar disorder?
    • Atack, JR. Are platelet and magnetic resonance spectroscopic changes indicative of altered PI signalling in bipolar disorder? Biol. Psychiatry 39:462-466, 1996.
    • (1996) Biol. Psychiatry , vol.39 , pp. 462-466
    • Atack, J.R.1
  • 4
    • 0029059660 scopus 로고
    • Inositol monophosphatase - A putative target for Li+ in the treatment of bipolar disorder
    • Atack, JR; Broughton, HB; and Pollack, SJ. Inositol monophosphatase - A putative target for Li+ in the treatment of bipolar disorder. Trends in Neurosciences (TIPS) 18:343-349, 1995.
    • (1995) Trends in Neurosciences (TIPS) , vol.18 , pp. 343-349
    • Atack, J.R.1    Broughton, H.B.2    Pollack, S.J.3
  • 5
    • 0025344325 scopus 로고
    • Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients
    • Banks, RE; Aiton, JF; Cramb, G; and Naylor, GJ. Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients. J. Affect. Disord. 19:1-8, 1990.
    • (1990) J. Affect. Disord. , vol.19 , pp. 1-8
    • Banks, R.E.1    Aiton, J.F.2    Cramb, G.3    Naylor, G.J.4
  • 6
    • 0024418268 scopus 로고
    • Second messenger systems and psychoactive drug action: Focus on the phosphoinositide system and lithium
    • Baraban, JM; Worley, PF; and Snyder, SH. Second messenger systems and psychoactive drug action: Focus on the phosphoinositide system and lithium. Am. J. Psychiatry 146:1251-1260, 1989.
    • (1989) Am. J. Psychiatry , vol.146 , pp. 1251-1260
    • Baraban, J.M.1    Worley, P.F.2    Snyder, S.H.3
  • 7
    • 0029875448 scopus 로고    scopus 로고
    • How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory
    • Belmaker, RH; Bersudsky, Y; Agam, G; Levine, J; and Kofman, O. How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory. Annu. Rev. Med. 47:47-56, 1996.
    • (1996) Annu. Rev. Med. , vol.47 , pp. 47-56
    • Belmaker, R.H.1    Bersudsky, Y.2    Agam, G.3    Levine, J.4    Kofman, O.5
  • 9
    • 0027984504 scopus 로고
    • Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls
    • Berk, M; Bodemer, W; van Oudenhove, T; and Butkow, N. Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls. Int. Clin. Psychopharmacol 9:291-293, 1994.
    • (1994) Int. Clin. Psychopharmacol , vol.9 , pp. 291-293
    • Berk, M.1    Bodemer, W.2    Van Oudenhove, T.3    Butkow, N.4
  • 11
    • 0024341795 scopus 로고
    • Neural and developmental actions of lithium: A unifying hypothesis
    • Berridge, MJ; Downes, CP; and Hanley, MR. Neural and developmental actions of lithium: A unifying hypothesis. Cell 59:411-419, 1989.
    • (1989) Cell , vol.59 , pp. 411-419
    • Berridge, M.J.1    Downes, C.P.2    Hanley, M.R.3
  • 14
    • 0027165721 scopus 로고
    • Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania
    • Brown, AS; Mallinger, AG; and Renbaum, LC. Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania. Am. J. Psychiatry 150:1252-1254, 1993.
    • (1993) Am. J. Psychiatry , vol.150 , pp. 1252-1254
    • Brown, A.S.1    Mallinger, A.G.2    Renbaum, L.C.3
  • 15
    • 0029036333 scopus 로고
    • Abnormal frontal lobe phosphorous metabolism in bipolar disorder
    • Deicken, RF; Fein, G; and Weiner, MW. Abnormal frontal lobe phosphorous metabolism in bipolar disorder. Am. J. Psychiatry 152:915-918, 1995a.
    • (1995) Am. J. Psychiatry , vol.152 , pp. 915-918
    • Deicken, R.F.1    Fein, G.2    Weiner, M.W.3
  • 16
    • 0028958244 scopus 로고
    • Decreased temporal lobe phosphomonoesters in bipolar disorder
    • Deicken, RF; Weiner, MW; and Fein, G. Decreased temporal lobe phosphomonoesters in bipolar disorder. J. Affect. Disord. 33:195-199, 1995b.
    • (1995) J. Affect. Disord. , vol.33 , pp. 195-199
    • Deicken, R.F.1    Weiner, M.W.2    Fein, G.3
  • 18
    • 0024277408 scopus 로고
    • Lithium affects G-protein receptor coupling
    • Drummond, AH. Lithium affects G-protein receptor coupling. Nature 331:388, 1988.
    • (1988) Nature , vol.331 , pp. 388
    • Drummond, A.H.1
  • 20
    • 0025758913 scopus 로고
    • Elevated platelet intracellular calcium concentration in bipolar depression
    • Dubovsky, SL; Lee, C; Christiano, J; and Murphy, J. Elevated platelet intracellular calcium concentration in bipolar depression. Biol. Psychiatry 29:441-450, 1991.
    • (1991) Biol. Psychiatry , vol.29 , pp. 441-450
    • Dubovsky, S.L.1    Lee, C.2    Christiano, J.3    Murphy, J.4
  • 21
    • 0026579550 scopus 로고
    • The calcium second messenger system in bipolar disorders: Data supporting new research directions
    • Dubovsky, SL; Murphy, J; Christiano, J; and Lee, C. The calcium second messenger system in bipolar disorders: Data supporting new research directions. J. Neuropsychiatry Clin. Neurosci. 4:3-14, 1992a.
    • (1992) J. Neuropsychiatry Clin. Neurosci. , vol.4 , pp. 3-14
    • Dubovsky, S.L.1    Murphy, J.2    Christiano, J.3    Lee, C.4
  • 22
    • 0026558672 scopus 로고
    • Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients
    • Dubovsky, SL; Murphy, J; Thomas, M; and Rademacher, J. Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am. J. Psychiatry 149:118-120, 1992b.
    • (1992) Am. J. Psychiatry , vol.149 , pp. 118-120
    • Dubovsky, S.L.1    Murphy, J.2    Thomas, M.3    Rademacher, J.4
  • 23
    • 0028281236 scopus 로고
    • Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder
    • Dubovsky, SL; Thomas, M; Hijazi, A; and Murphy, J. Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder. Eur. Arch. Psychiatry Clin. Neurosci. 243:229-234, 1994.
    • (1994) Eur. Arch. Psychiatry Clin. Neurosci. , vol.243 , pp. 229-234
    • Dubovsky, S.L.1    Thomas, M.2    Hijazi, A.3    Murphy, J.4
  • 25
    • 0027518220 scopus 로고
    • Elevated intracellular calcium levels after 5HT2 receptor stimulation in platelets of depressed patients
    • Eckert, A; Gann, H; Riemann, D; Aldenhoff, J; and Muller, WE. Elevated intracellular calcium levels after 5HT2 receptor stimulation in platelets of depressed patients. Biol. Psychiatry 34:565-568, 1993.
    • (1993) Biol. Psychiatry , vol.34 , pp. 565-568
    • Eckert, A.1    Gann, H.2    Riemann, D.3    Aldenhoff, J.4    Muller, W.E.5
  • 29
    • 0027278902 scopus 로고
    • Altered platelet protein kinase C activity in bipolar affective disorder, manic episode
    • Friedman, E; Hoau-Yan-Wang; Levinson, D; Connell, TA; and Singh, H. Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol. Psychiatry 33:520-525, 1993.
    • (1993) Biol. Psychiatry , vol.33 , pp. 520-525
    • Friedman, E.1    Wang, H.Y.2    Levinson, D.3    Connell, T.A.4    Singh, H.5
  • 32
    • 0027437727 scopus 로고
    • The phosphoinositide signalling system. I. Historical background. II. Effects of lithium on the accumulation of second messenger inositol 1,4,5-trisphosphate in brain cortex slices
    • Hokin, LE, and Dixon, JF. The phosphoinositide signalling system. I. Historical background. II. Effects of lithium on the accumulation of second messenger inositol 1,4,5-trisphosphate in brain cortex slices. [Review]. Prog. Brain Res. 98:309-315, 1993.
    • (1993) Prog. Brain Res. , vol.98 , pp. 309-315
    • Hokin, L.E.1    Dixon, J.F.2
  • 33
    • 0027401398 scopus 로고
    • CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia
    • Hudson, CJ; Young, LT; Li, PP; and Warsh, JJ. CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia. Synapse 13:278-293, 1993.
    • (1993) Synapse , vol.13 , pp. 278-293
    • Hudson, C.J.1    Young, L.T.2    Li, P.P.3    Warsh, J.J.4
  • 34
    • 0026552893 scopus 로고
    • Membrane trapping of carbon-11-labeled 1,2-diacylglycerols as a basic concept for assessing phosphatidyl-inositol turnover in neurotransmission process
    • Imahori, Y; Fujii, R; Ueda, S; Matsumoto, K; Wakita, K; Ido, T; Nariai, T; Nakahashi, H. Membrane trapping of carbon-11-labeled 1,2-diacylglycerols as a basic concept for assessing phosphatidyl-inositol turnover in neurotransmission process. J. Nucl. Med. 33:413-422, 1992.
    • (1992) J. Nucl. Med. , vol.33 , pp. 413-422
    • Imahori, Y.1    Fujii, R.2    Ueda, S.3    Matsumoto, K.4    Wakita, K.5    Ido, T.6    Nariai, T.7    Nakahashi, H.8
  • 35
    • 0029950633 scopus 로고    scopus 로고
    • The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain
    • Jope, RS; Song, L; Li, PP; Young, LT; Kish, SJ; Pacheco, MA; and Warsh, JJ. The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. J. Neurochem. 66:2402-2409, 1996.
    • (1996) J. Neurochem. , vol.66 , pp. 2402-2409
    • Jope, R.S.1    Song, L.2    Li, P.P.3    Young, L.T.4    Kish, S.J.5    Pacheco, M.A.6    Warsh, J.J.7
  • 36
    • 0028220947 scopus 로고
    • Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder
    • Kato, T; Shioiri, T; Murashita, J; Hamakawa, H; Inubushi, T; and Takahashi, S. Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder. Psychiatry Res. 55:41-50, 1994a.
    • (1994) Psychiatry Res. , vol.55 , pp. 41-50
    • Kato, T.1    Shioiri, T.2    Murashita, J.3    Hamakawa, H.4    Inubushi, T.5    Takahashi, S.6
  • 37
    • 0029004598 scopus 로고
    • Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS
    • Kato, T; Shioiri, T; Murashita, J; Hamakawa, H; Takahashi, Y; Inubushi, T; and Takahashi, S. Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS. Psychol. Med. 25:557-566, 1995.
    • (1995) Psychol. Med. , vol.25 , pp. 557-566
    • Kato, T.1    Shioiri, T.2    Murashita, J.3    Hamakawa, H.4    Takahashi, Y.5    Inubushi, T.6    Takahashi, S.7
  • 38
    • 0025850362 scopus 로고
    • Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS
    • Kato, T; Shioiri, T; Takahashi, S; and Inubushi, T. Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS. J. Affect. Disord. 22:185-190, 1991.
    • (1991) J. Affect. Disord. , vol.22 , pp. 185-190
    • Kato, T.1    Shioiri, T.2    Takahashi, S.3    Inubushi, T.4
  • 39
    • 0026453704 scopus 로고
    • Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy
    • Kato, T; Takahashi, S; Shioiri, T; and Inubushi, T. Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. J. Affect. Disord. 26:223-230, 1992.
    • (1992) J. Affect. Disord. , vol.26 , pp. 223-230
    • Kato, T.1    Takahashi, S.2    Shioiri, T.3    Inubushi, T.4
  • 40
    • 0027339579 scopus 로고
    • Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy
    • Kato, T; Takahashi, S; Shioiri, T; and Inubushi, T. Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. J. Affect. Disord. 27:53-59, 1993.
    • (1993) J. Affect. Disord. , vol.27 , pp. 53-59
    • Kato, T.1    Takahashi, S.2    Shioiri, T.3    Inubushi, T.4
  • 41
    • 0028352678 scopus 로고
    • Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy
    • Kato, T; Takahashi, S; Shioiri, T; Murashita, J; Hamakawa, H; and Inubushi, T. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J. Affect. Disord. 31:125-133, 1994b.
    • (1994) J. Affect. Disord. , vol.31 , pp. 125-133
    • Kato, T.1    Takahashi, S.2    Shioiri, T.3    Murashita, J.4    Hamakawa, H.5    Inubushi, T.6
  • 42
    • 0025923910 scopus 로고
    • Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients
    • Kusumi, I; Koyama, T; and Yamashita, I. Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients. Biol. Psychiatry 30:311-312, 1991.
    • (1991) Biol. Psychiatry , vol.30 , pp. 311-312
    • Kusumi, I.1    Koyama, T.2    Yamashita, I.3
  • 43
    • 0026539939 scopus 로고
    • Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders
    • Kusumi, I; Koyama, T; and Yamashita, I. Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders. Biol. Psychiatry 32:731-734, 1992.
    • (1992) Biol. Psychiatry , vol.32 , pp. 731-734
    • Kusumi, I.1    Koyama, T.2    Yamashita, I.3
  • 44
    • 0024378597 scopus 로고
    • Abnormal signal transduction: A hypothetical model for bipolar affective disorder
    • Lachman, HM, and Papolos, DF. Abnormal signal transduction: A hypothetical model for bipolar affective disorder. Life Sci. 45:1413-1426, 1989.
    • (1989) Life Sci. , vol.45 , pp. 1413-1426
    • Lachman, H.M.1    Papolos, D.F.2
  • 45
    • 0028810958 scopus 로고
    • A molecular model for bipolar affective disorder
    • Lachman, HM, and Papolos, DF. A molecular model for bipolar affective disorder. Med. Hypoth. 45:255-264, 1995.
    • (1995) Med. Hypoth. , vol.45 , pp. 255-264
    • Lachman, H.M.1    Papolos, D.F.2
  • 47
    • 0028219446 scopus 로고
    • Lithium and the brain: A psychopharmacological strategy to a molecular basis for manic depressive illness
    • Lenox, RH, and Watson, DG. Lithium and the brain: A psychopharmacological strategy to a molecular basis for manic depressive illness. [Review]. Clin. Chem. 40:309-314, 1994.
    • (1994) Clin. Chem. , vol.40 , pp. 309-314
    • Lenox, R.H.1    Watson, D.G.2
  • 49
    • 0027538623 scopus 로고
    • Analysis of complex mixtures of phospholipid classes from cell membranes using two-dimensional thin-layer chromatography and scanning laser densitometry
    • Mallinger, AG; Yao, JK; Brown, AS; and Dippold, CS. Analysis of complex mixtures of phospholipid classes from cell membranes using two-dimensional thin-layer chromatography and scanning laser densitometry. J. Chromatogr. 614:67-75, 1993.
    • (1993) J. Chromatogr. , vol.614 , pp. 67-75
    • Mallinger, A.G.1    Yao, J.K.2    Brown, A.S.3    Dippold, C.S.4
  • 50
    • 0027366278 scopus 로고
    • Lithium decreases membrane-associated protein kinase C in hippocampus: Selectivity for the alpha isozyme
    • Manji, HK; Etcheberrigaray, R; Chen, G; and Olds, JL. Lithium decreases membrane-associated protein kinase C in hippocampus: Selectivity for the alpha isozyme. J. Neurochem. 61:2303-2310, 1993.
    • (1993) J. Neurochem. , vol.61 , pp. 2303-2310
    • Manji, H.K.1    Etcheberrigaray, R.2    Chen, G.3    Olds, J.L.4
  • 51
    • 0027972567 scopus 로고
    • Long-term action of lithium: A role for transcriptional and posttranscriptional factors regulated by protein kinase C
    • Manji, HK, and Lenox, RH. Long-term action of lithium: A role for transcriptional and posttranscriptional factors regulated by protein kinase C. Synapse 16:11-28, 1994.
    • (1994) Synapse , vol.16 , pp. 11-28
    • Manji, H.K.1    Lenox, R.H.2
  • 52
    • 0029044932 scopus 로고
    • Signal transduction pathways. Molecular targets for lithium's actions
    • Manji, HK; Potter, WZ; and Lenox, RH. Signal transduction pathways. Molecular targets for lithium's actions. [Review]. Arch. Gen. Psychiatry 52:531-543, 1995.
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 531-543
    • Manji, H.K.1    Potter, W.Z.2    Lenox, R.H.3
  • 53
    • 0027980879 scopus 로고
    • Decreased CS inositol monophosphatase activity after lithium treatment
    • Molchan, SE; Atack, JR; and Sunderland, T. Decreased CS inositol monophosphatase activity after lithium treatment. Psychiatry Res. 53:103-105, 1994.
    • (1994) Psychiatry Res. , vol.53 , pp. 103-105
    • Molchan, S.E.1    Atack, J.R.2    Sunderland, T.3
  • 54
    • 0027453433 scopus 로고
    • Effects of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects
    • Molchan, SE; Manji, H; Chen, G; Dou, L; Little, J; Potter, WZ; and Sunderland, T. Effects of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects. Neurosci. Lett. 162:187-191, 1993.
    • (1993) Neurosci. Lett. , vol.162 , pp. 187-191
    • Molchan, S.E.1    Manji, H.2    Chen, G.3    Dou, L.4    Little, J.5    Potter, W.Z.6    Sunderland, T.7
  • 55
    • 0026074687 scopus 로고
    • Platelet alpha-2 adrenergic receptor-mediated phosphoinositide responses in endogenous depression
    • Mori, H; Koyama, T; and Yamashita, I. Platelet alpha-2 adrenergic receptor-mediated phosphoinositide responses in endogenous depression. Life Sci. 48:741-748, 1991.
    • (1991) Life Sci. , vol.48 , pp. 741-748
    • Mori, H.1    Koyama, T.2    Yamashita, I.3
  • 56
    • 0027007777 scopus 로고
    • Effects of lithium on second messenger systems in the brain
    • Mork, A; Geisler, A; and Hollund, P. Effects of lithium on second messenger systems in the brain. [Review]. Pharmacol. Toxicol. 71(Suppl. 1):4-17, 1992.
    • (1992) Pharmacol. Toxicol. , vol.71 , Issue.1 SUPPL. , pp. 4-17
    • Mork, A.1    Geisler, A.2    Hollund, P.3
  • 57
    • 0025321883 scopus 로고
    • Inositol-1-phosphatase in red blood cells of manic-depressive patients before and during treatment with lithium
    • Moscovich, DG; Belmaker, RH; Agam, G; and Livne, A. Inositol-1-phosphatase in red blood cells of manic-depressive patients before and during treatment with lithium. Biol. Psychiatry 27:552-555, 1990.
    • (1990) Biol. Psychiatry , vol.27 , pp. 552-555
    • Moscovich, D.G.1    Belmaker, R.H.2    Agam, G.3    Livne, A.4
  • 58
    • 0027473867 scopus 로고
    • Protein kinase C imaging using carbon-11-labeled phorbol 13-isobutyrate-20-[1-11C]butyrate as the potential ligand for positron emission tomography
    • Ohmori, Y; Imahori, Y; Ueda, S; Fujii, R; Ido, T; Wakita, K; and Nakahashi, H. Protein kinase C imaging using carbon-11-labeled phorbol 13-isobutyrate-20-[1-11C]butyrate as the potential ligand for positron emission tomography. J. Nucl. Med. 34:431-439, 1993.
    • (1993) J. Nucl. Med. , vol.34 , pp. 431-439
    • Ohmori, Y.1    Imahori, Y.2    Ueda, S.3    Fujii, R.4    Ido, T.5    Wakita, K.6    Nakahashi, H.7
  • 59
    • 0028869503 scopus 로고
    • Serotonin-induced platelet calcium mobilization is enhanced in mania
    • Okamoto, Y; Kagaya, A; Shinno, H; Motohashi, N; and Yamawaki, S. Serotonin-induced platelet calcium mobilization is enhanced in mania. Life Sci. 56:327-332, 1995.
    • (1995) Life Sci. , vol.56 , pp. 327-332
    • Okamoto, Y.1    Kagaya, A.2    Shinno, H.3    Motohashi, N.4    Yamawaki, S.5
  • 61
    • 0022855739 scopus 로고
    • Blood platelets as neuronal models: Use and limitations
    • Pletscher, A. Blood platelets as neuronal models: Use and limitations. Clin. Neuropharmacol. 9:344-346, 1986.
    • (1986) Clin. Neuropharmacol. , vol.9 , pp. 344-346
    • Pletscher, A.1
  • 63
    • 0026463926 scopus 로고
    • A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: Review and critical analysis
    • Robinson, PJ; Noronha, J; DeGeorge, JJ; Freed, LM; Nariai, T; and Rapoport, SI. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: Review and critical analysis. Brain Res. Rev. 17:187-214, 1992.
    • (1992) Brain Res. Rev. , vol.17 , pp. 187-214
    • Robinson, P.J.1    Noronha, J.2    DeGeorge, J.J.3    Freed, L.M.4    Nariai, T.5    Rapoport, S.I.6
  • 65
    • 0025784323 scopus 로고
    • Lithium sensitive G protein hyperfunction: A dynamic model for the pathogenesis of bipolar affective disorder
    • Schreiber, G, and Avissar, S. Lithium sensitive G protein hyperfunction: A dynamic model for the pathogenesis of bipolar affective disorder. Med. Hypoth. 35:237-243, 1991.
    • (1991) Med. Hypoth. , vol.35 , pp. 237-243
    • Schreiber, G.1    Avissar, S.2
  • 66
    • 0026665540 scopus 로고
    • Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients
    • Sharma, R; Venkatasubramanian, PN; Barany, M; and Davis, JM. Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients. Schizophr. Res. 8:43-49, 1992.
    • (1992) Schizophr. Res. , vol.8 , pp. 43-49
    • Sharma, R.1    Venkatasubramanian, P.N.2    Barany, M.3    Davis, J.M.4
  • 68
    • 0030586852 scopus 로고    scopus 로고
    • Chronic lithium does not alter human myo-inositol or phosphomonoester concentrations as measured by 1H and 31P MRS
    • Silverstone, PH; Hanstock, CC; Fabian, J; Staab, R; and Allen, PS. Chronic lithium does not alter human myo-inositol or phosphomonoester concentrations as measured by 1H and 31P MRS. Biol. Psychiatry 40:235-246, 1996.
    • (1996) Biol. Psychiatry , vol.40 , pp. 235-246
    • Silverstone, P.H.1    Hanstock, C.C.2    Fabian, J.3    Staab, R.4    Allen, P.S.5
  • 69
    • 0026566240 scopus 로고
    • Second messengers and affective illness - Focus on the phosphoinositide cycle
    • Snyder, SH. Second messengers and affective illness - Focus on the phosphoinositide cycle. Pharmacopsychiatry 25:25-28, 1992.
    • (1992) Pharmacopsychiatry , vol.25 , pp. 25-28
    • Snyder, S.H.1
  • 70
    • 0030889081 scopus 로고    scopus 로고
    • Platelet membrane phosphatidylinositol-4,5-bisphosphate alterations in bipolar disorder - Evidence from a single case study
    • Soares, JC; Dippold, CS; and Mallinger, AG. Platelet membrane phosphatidylinositol-4,5-bisphosphate alterations in bipolar disorder - Evidence from a single case study. Psychiatry Res. 69:197-202, 1997a.
    • (1997) Psychiatry Res. , vol.69 , pp. 197-202
    • Soares, J.C.1    Dippold, C.S.2    Mallinger, A.G.3
  • 71
    • 0345031222 scopus 로고    scopus 로고
    • Platelet membrane phospholipids in euthymic bipolar disorder patients: Are they affected by lithium treatment?
    • in press
    • Soares, JC; Dippold, CS; Mallinger, AG; Frank, E; and Kupfer, DJ. Platelet membrane phospholipids in euthymic bipolar disorder patients: Are they affected by lithium treatment? Biol. Psychiatry, in press, 1997b.
    • (1997) Biol. Psychiatry
    • Soares, J.C.1    Dippold, C.S.2    Mallinger, A.G.3    Frank, E.4    Kupfer, D.J.5
  • 72
    • 0029855764 scopus 로고    scopus 로고
    • Nuclear magnetic resonance spectroscopy - New insights into the pathophysiology of mood disorders
    • Soares, JC; Krishnan, KRR; and Keshavan, MS. Nuclear magnetic resonance spectroscopy - New insights into the pathophysiology of mood disorders. Depression 4:14-30, 1996.
    • (1996) Depression , vol.4 , pp. 14-30
    • Soares, J.C.1    Krishnan, K.R.R.2    Keshavan, M.S.3
  • 73
    • 0030584457 scopus 로고    scopus 로고
    • Abnormal phosphatidylinositol (PI)-signalling in bipolar disorder
    • Soares, JC, and Mallinger, AG. Abnormal phosphatidylinositol (PI)-signalling in bipolar disorder. Biol. Psychiatry 39:461-462, 1996.
    • (1996) Biol. Psychiatry , vol.39 , pp. 461-462
    • Soares, J.C.1    Mallinger, A.G.2
  • 74
    • 0022400685 scopus 로고
    • Peripheral models for the study of neurotransmitter receptors in man
    • Stahl, SM. Peripheral models for the study of neurotransmitter receptors in man. Psychopharmacol. Bull. 21:663-671, 1985.
    • (1985) Psychopharmacol. Bull. , vol.21 , pp. 663-671
    • Stahl, S.M.1
  • 75
    • 0029089840 scopus 로고
    • Myo-inositol monophosphatase: Diverse effects of lithium, carbamazepine, and valproate
    • Vadnal, R, and Parthasarathy, R. Myo-inositol monophosphatase: Diverse effects of lithium, carbamazepine, and valproate. Neuropsychopharmacol. 12:277-285, 1995.
    • (1995) Neuropsychopharmacol. , vol.12 , pp. 277-285
    • Vadnal, R.1    Parthasarathy, R.2
  • 76
    • 0027304657 scopus 로고
    • Increased sensitivity to agonist stimulation of the Ca2+ response in neutrophils of manic-depressive patients: Effect of lithium therapy
    • van Calker, D; Forstner, U; Bohus, M; Gebicke-Harter, P; Hecht, H; Wark, HJ; and Berger, M. Increased sensitivity to agonist stimulation of the Ca2+ response in neutrophils of manic-depressive patients: Effect of lithium therapy. Neuropsychobiol. 27:180-183, 1993.
    • (1993) Neuropsychobiol. , vol.27 , pp. 180-183
    • Van Calker, D.1    Forstner, U.2    Bohus, M.3    Gebicke-Harter, P.4    Hecht, H.5    Wark, H.J.6    Berger, M.7
  • 77
    • 0024570010 scopus 로고
    • Dysbalance of neuronal second messenger function in the aetiology of affective disorders: A pathophysiological concept hypothesizing defects beyond first messenger receptors
    • Wachtel, H. Dysbalance of neuronal second messenger function in the aetiology of affective disorders: A pathophysiological concept hypothesizing defects beyond first messenger receptors. J. Neural Transm. 75:21-29, 1989.
    • (1989) J. Neural Transm. , vol.75 , pp. 21-29
    • Wachtel, H.1
  • 78
    • 0025010781 scopus 로고
    • The second-messenger dysbalance hypothesis of affective disorders
    • Wachtel, H. The second-messenger dysbalance hypothesis of affective disorders. Pharmacopsychiatry 23:27-32, 1990.
    • (1990) Pharmacopsychiatry , vol.23 , pp. 27-32
    • Wachtel, H.1


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