Selective inhibition of endothelin receptor A as an anti-angiogenic and anti-proliferative strategy for human pancreatic cancer

Journal of Gastrointestinal Surgery

Volumn 9, Issue 5, 2005, Pages 703-709

  Bhargava, Sarah ^a   Stummeyer, Till ^a   Hotz, Birgit ^a   Hines, O Joe ^b   Reber, Howard A ^b   Buhr, Heinz J ^a   Hotz, Hubert G ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; Endothelin 1; Pancreatic cancer; Vascular endothelial growth factor

Indexed keywords

ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; LU 302146;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; EXPERIMENTATION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; MALE; MEASUREMENT; METASTASIS; MOUSE; NONHUMAN; RECEPTOR AFFINITY; RECEPTOR BLOCKING;

EID: 18044394375     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gassur.2004.11.007     Document Type: Article

References (30)

1. S.L. Parker, T. Tong, S. Bolden, and P.A. Wingo Cancer statistics, 1997 CA Cancer J Clin 47 1997 5 27
2. C.J. Yeo, and J.L. Cameron Pancreatic cancer Curr Probl Surg 36 1999 59 152
3. T.J. Howard Pancreatic adenocarcinoma Curr Probl Cancer 20 1996 281 328
4. L. Rosenberg Pancreatic cancer: A review of emerging therapies Drugs 59 2000 1071 1089
5. K. Grant, M. Loizidou, and I. Taylor Endothelin-1: A multifunctional molecule in cancer Br J Cancer 88 2003 163 166
6. A. Bagnato, and F. Spinella Emerging role of endothelin-1 in tumor angiogenesis Trends Endocrinol Metab 14 2002 44 50
7. T. Oikawa, M. Kushuhara, and S. Ishikawa Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells Br J Cancer 69 1994 1059 1064
8. M. Kusuhara, K. Yamaguchi, and K. Nagasaki Production of endothelin in human cancer cell lines Cancer Res 50 1990 3257 3261
9. E.H. Asham, M. Loizidou, and I. Taylor Endothelin-1 and tumour development Eur J Surg Oncol 24 1998 57 60
10. D. Salani, G. Taraboletti, and L. Rosano Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo Am J Pathol 157 2000 1703 1711
11. A. Bagnato, D. Salani, and V. Di Castro Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: Evidence for an autocrine role in tumor growth Cancer Res 59 1999 720 727
12. F. Spinella, L. Rosano, V. Di Castro, P.G. Natali, and A. Bagnato Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1alpha in ovarian carcinoma cells J Biol Chem 277 2002 27850 27855
13. M. Guba, H. Seeliger, A. Kleespies, K.W. Jauch, and C. Bruns Vascular endothelial growth factor in colorectal cancer Int J Colorectal Dis 19 2004 510 517
14. L. Peduto Eberl, R. Bovey, and L. Juillerat-Jeanneret Endothelin-receptor antagonists are proapoptotic and anti-proliferative in human colon cancer cells Br J Cancer 88 2003 788 795
15. D. Salani, L. Rosano, and V. Di Castro ABT-627, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma growth in vitro Clin Sci (Lond) 103 Suppl 48 2002 318 321S
16. L. Rosano, F. Spinella, and V. Di Castro Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo Am J Pathol 163 2003 753 762
17. A. Venuti, D. Salani, and A. Cirilli Endothelin receptor blockade inhibits the growth of human papillomavirus-associated cervical carcinoma Clin Sci (Lond) 103 Suppl 48 2002 310 313S
18. A. Bagnato, and P.G. Natali Endothelin receptors as novel targets in tumor therapy J Transl Med 2 2004 16
19. L. Rosano, F. Spinella, and D. Salani Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma Cancer Res 63 2003 2447 2453
20. A. Bagnato, A. Cirilli, and D. Salani Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade Cancer Res 62 2002 6381 6384
21. L.K. Lassiter, and M.A. Carducci Endothelin receptor antagonists in the treatment of prostate cancer Semin Oncol 30 2003 678 688
22. B. Sipos, S. Moser, H. Kalthoff, V. Torok, M. Lohr, and G. Kloppel A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform Virchows Arch 442 2003 444 452
23. H.G. Hotz, H.A. Reber, and B. Hotz An orthotopic nude mouse model for evaluating pathophysiology and therapy of pancreatic cancer Pancreas 26 2003 e89 e98
24. N. Weidner Intratumor microvessel density as a prognostic factor in cancer Am J Pathol 147 1995 9 19
25. N. Weidner Tumoral vascularity as a prognostic factor in cancer patients: The evidence continues to grow J Pathol 184 1998 119 122
26. K. Kuwahara, T. Sasaki, Y. Kuwada, M. Murakami, S. Yamasaki, and K. Chayama Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival Pancreas 26 2003 344 349
27. A. Cruz, C. Parnot, D. Ribatti, P. Corvol, and J.M. Gasc Endothelin-1, a regulator of angiogenesis in the chick chorioallantoic membrane J Vasc Res 38 2001 536 545
28. D. Salani, V. Di Castro, and M.R. Nicotra Role of endothelin-1 in neovascularization of ovarian carcinoma Am J Pathol 157 2000 1537 1547
29. J.P. Duffy, G. Eibl, H.A. Reber, and O.J. Hines Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer Mol Cancer 2 2003 12
30. A.C. Koong, V.K. Mehta, and Q.T. Le Pancreatic tumors show high levels of hypoxia Int J Radiat Oncol Biol Phys 48 2000 919 922