ABT-627, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma growth in vitro

Clinical Science

Volumn 103, Issue SUPPL. 48, 2002, Pages

  Salani, Debora ^a   Rosanò, Laura ^a   Di Castro, Valeriana ^a   Spinella, Francesca ^a   Venuti, Aldo ^a   Padley, Robert J ^a   Nicotra, Maria Rita ^a   Natali, Pier Giorgio ^a   Bagnato, Anna ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Autocrine factor; G protein coupled receptor; Mitogenic effect

Indexed keywords

ATRASENTAN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR AGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; CANCER INVASION; CANCER THERAPY; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOGENESIS; NEOVASCULARIZATION (PATHOLOGY); OVARY CARCINOMA; PRIORITY JOURNAL;

EID: 0036670301     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs103s318s     Document Type: Conference Paper

References (10)

1. Carcinoma of the ovary: A clinicopathological study of 86 autopsied cases with a special reference to mode of spread
2. Endothelins
3. Expression of Endothelin-1 and endothelin A receptor in ovarian carcinoma: Evidence for an autocrine role in tumor growth
4. Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells
5. Role of endothelin-1 in neovascularization of ovarian carcinoma
6. Endothelin-1 promotes proteolytic activity of ovarian carcinoma
7. Pharmacokinetics and pharmacodynamic effects of ABT-627, an oral ETA selective endothelin antagonist, in humans
8. Irreversible endothelin-1 binding does not prohibit ABT-627 from reversing Endothelin-1-induced effects
9. Activation of mitogenic signaling by endothelin-1 in ovarian carcinoma cells
10. Transactivation of the epidermal growth factor receptor in endothelin-1 in neovascularization of ovarian carcinoma