Methylprednisolone inhibits production of interleukin-1β and interleukin-6 in the spinal cord following compression injury in rats

Journal of Neurosurgical Anesthesiology

Volumn 17, Issue 2, 2005, Pages 82-85

  Fu, Eugene S ^a   Saporta, Samuel ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Cytokines; Interleukins; Methylprednisolone; Spinal cord injury

Indexed keywords

GLUCOCORTICOID; HALOTHANE; INTERLEUKIN 1BETA; INTERLEUKIN 6; METHYLPREDNISOLONE; SODIUM CHLORIDE;

ANALYSIS OF VARIANCE; ANEURYSM CLIP; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG DOSE REGIMEN; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FEMALE; LAMINECTOMY; MOLECULAR INTERACTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SINGLE DRUG DOSE; SPINAL CORD COMPRESSION; SPINAL CORD INJURY;

ANIMALS; FEMALE; INTERLEUKIN-1; INTERLEUKIN-6; METHYLPREDNISOLONE; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD COMPRESSION;

EID: 18044387971     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ana.0000163199.10365.38     Document Type: Article

References (31)

1. Fehlings MG, Sekhorn LHS, Tator C. The role and timing of decompression in acute spinal cord injury. Spine. 2001;26:S101-S110.
2. Tator CH, Fehlings MG, Thorpe K, et al. Current use and timing of spinal surgery for management of acute spinal surgery for management of acute spinal cord injury in North America: results of a retrospective multicenter study. J Neurosurg. 1999;91:12-18.
3. Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury: results of the Second National Acute Spinal Cord Injury Study. N Engl J Med. 1990;322:1405-1411.
4. Bracken MB, Shepard MJ, Holfor TR, et al. Administration of methylprednisolone for 24 or 48 hours of tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury: results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA. 1997;277:1597-1604.
5. Hall ED. Neuroprotective actions of glucocorticoid and nonglucocorticoid steroids in acute neuronal injury. Cell Mol Neurobiol. 1993;13:415-432.
6. +)- ATPase activity. Dose-response analysis during 1st hour after contusion injury in the cat. J Neurosurg. 1982;49:563-568.
7. Chikawa T, Ikata T, Katoh S, et al. Preventive effects of lecithinized Superoxide dismutase and methylprednisolone on spinal cord injury in rats: transcriptional regulation of inflammatory and neurotrophic genes. J Neurotrauma. 2001;18:93-103.
8. Bartholdi D, Schwab ME. Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after spinal cord lesion in the rat. Brain Res. 1995;672:177-186.
9. Wang CX, Olschowka JA, Wrathall JR. Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat. Brain Res. 1997;759:190-196.
10. Benveniste EN. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am J Physiol. 1992;263:C1-16.
11. Yan HQ, Banos MA, Hooghe R, et al. Expression of interleukin (IL)-1 beta, IL-6 and their respective receptor in the normal rat brain and after injury. Eur J Immunol. 1992;22:2963-2971.
12. Schöbitz B, Ron De Kloet E, Holsboer F. Gene expression and function of interlekin 1, interleukin 6 and tumor necrosis factor in the brain. Prog Neurobiol. 1994;44:397-430.
13. Kamencic H, Griebel RW, Lyon AW, et al. Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function. FASEB J. 2001;15:243-250.
14. Tuna M, Polat S, Ermin T, et al. Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: inducible nitric oxide synthase expression, sodium- and potassium-activated, magnesium-dependent adenosine-5′-triphosphatase and Superoxide dismutase activation, and ultrastructural changes. J Neurosurg. 2001;95(1 Suppl):64-73.
15. Relton JK, Rothwell NJ. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res Bull. 1992;29:243-246.
16. Nesic O, Xu GY, McAdoo D, et al. IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury. J Neurotrauma. 2001;18:947-956.
17. Rivlin AS, Tator CH. Effect of duration of acute spinal cord compression in a new acute injury model in the rat. Surg Neurol. 1979;9:39-43.
18. Xu J, Fan G, Chen S, et al. Methylprednisolone inhibition of TNF-α expression and NF-kappaB activation after spinal cord injury in rats. Brain Res Mol Brain Res. 1998;59:135-142.
19. Sumida M, Inaba H, Isawa E, et al. Prevention by methylprednisolone of increased circulating tumor necrosis factor-alpha levels and lung injury associated with systemic inflammatory response syndrome due to intraperitoneal hyperthermia. Anesth Analg. 1999;88:771-776.
20. Hill GE, Alonso A, Spurzem JR, et al. Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induce inflammation in humans. J Thorac Cardiovasc Surg. 1995;110:1658-1662.
21. Kiberd BA, Young ID. Modulation of glomerular structure and function in murine lupus nephritis by methylprednisolone and cyclophosphamide. J Lab Clin Med. 1994;124:496-506.
22. Bartholdi D, Schwab ME. Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: an in situ hybridization study. Eur J Neurosci. 1997;9:1422-1438.
23. Klusman I, Schwab ME. Effects of pro-inflammatory cytokines in experimental spinal cord injury. Brain Res. 1997;762:173-184.
24. Morganti-Kossman MC, Lenzlinger PM, Hans V, et al. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol Psychiatry. 1997;2:133-136.
25. He J, Evans CO, Hoffman SW, et al. Progesterone and allopregnalone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol. 2004;189:404-412.
26. Gonzalez SL, Labombarda F, Gonzalez Deniselle MC, et al. Progesterone up-regulates neuronal brain-derived neurotrophic factor expression in the injured spinal cord. Neuroscience. 2004;125:605-614.
27. Rabchevsky AG, Fugaccia I, Sullivan PG, et al. Efficacy of methylpred-nisolone therapy for the injured rat spinal cord. J Neurosci Res. 2002;68:7-18.
28. Hurlbert RJ. Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J Neurosurg Spine. 2000;93:1-7.
29. Short D. Is the role of steroids in acute spinal cord injury now resolved? Curr Opin Neurol. 2001;14:759-763.
30. Coleman WP, Benzel E, Cahill DW, et al. A critical appraisal of the reporting of the National Acute Spinal Cord Injury Studies (II and III) of Methylprednisolone in Acute Spinal Cord Injury. J Spinal Disord. 2000;13:185-199.
31. American Association of the Neurologic Surgeons and the Congress of Neurologic Surgeons. Guidelines of the American Association of the Neurologic Surgeons and the Congress of Neurologic Surgeons. Pharmacological therapy after acute spinal cord injury. Neurosurgery 2002;50(suppl):63-72.