AH receptor, ARNT, glucocorticoid receptor, EGF receptor, EGF, TGFα, TGFβ1, TGFβ2, and TGFβ3 expression in human embryonic palate, and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Teratology

Volumn 58, Issue 2, 1998, Pages 30-43

  Abbott, B D ^a   Probst, M R ^b,d   Perdew, G H ^c   Buckalew, A R ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CARRIER PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ARTICLE; CELL FUSION; CELL HYPERPLASIA; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; EMBRYO; EMBRYO DEVELOPMENT; EPITHELIUM; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; PALATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; SPECIES DIFFERENCE; TEMPORAL LOBE; TERATOGENESIS;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; DNA-BINDING PROTEINS; ENVIRONMENTAL POLLUTANTS; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; GROWTH SUBSTANCES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; ORGAN CULTURE TECHNIQUES; PALATE; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTORS;

EID: 0031693559     PISSN: 00403709     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9926(199808)58:2<30::AID-TERA4>3.0.CO;2-4     Document Type: Article

References (42)

1. Abbott, B.D. (1997) Developmental toxicity of dioxin: Searching for the cellular and molecular basis of morphological responses. In: Handbook of Experimental Pharmacology 124/II: Drug Toxicity in Embryonic Development II. R.J. Kavlock and G.P. Daston, eds. New York: Springer-Verlag, pp. 407-433.
2. Abbott, B.D., and L.S. Birnbaum (1990a) Retinoic acid induced alterations in expression of growth factors in embryonic mouse palatal shelves. Teratology, 42:597-610.
3. Abbott, B.D., and L.S. Birnbaum (1990b) TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD. Toxicol. Appl. Pharmacol., 106:418-432.
4. Abbott, B.D., and L.S. Birnbaum (1991) TCDD exposure of human embryonic palatal shelves in organ culture alters the differentiation of medial epithelial cells. Teratology, 43:119-132.
5. Abbott, B.D., and A.R. Buckalew (1992) Embryonic palatal responses to teratogens in serum-free organ culture. Teratology, 45:369-382.
6. Abbott, B.D., and M.R. Probst (1995) Developmental expression of two members of a new class of transcriptional factors. Part II: Expression of Ah receptor nuclear translocator (ARNT) in the C57BL/6N mouse embryo. Dev. Dynam., 204:144-155.
7. Abbott, B.D., E.D. Adamson, and R.M. Pratt (1988) Retinoic acid alters EGF receptor expression during palatogenesis. Development, 102: 853-867.
8. Abbott, B.D., J.J. Diliberto, and L.S. Birnbaum (1989) TCDD alters embryonic palatal medial epithelial cell differentiation in vitro. Toxicol. Appl. Pharmacol., 100:119-131.
9. Abbott, B.D., G.H. Perdew, and L.S. Birnbaum (1994a) Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. Toxicol. Appl. Pharmacol., 126:16-25.
10. Abbott, B.D., F.M.A. McNabb, and C. Lau (1994b) Glucocorticoid receptor expression during the development of the embryonic mouse secondary palate. J. Craniofac. Genet. Dev. Biol., 14:87-96.
11. Abbott, B.D., G.H. Perdew, A.R. Buckalew, and L.S. Birnbaum (1994c) Interactive regulation of Ah and glucocorticoid receptors in the synergistic induction of cleft palate by TCDD and hydrocortisone. Toxicol. Appl. Pharmacol., 128:138-150.
12. Abbott, B.D., M.R. Probst, and G.H. Perdew (1994d) Immunohistochemical double-staining for Ah receptor and ARNT in human embryonic palatal shelves. Teratology, 50:361-366.
13. Abbott, B.D., L.D. Birnbaum, and G.H. Perdew (1995) Developmental expression of two members of a new class of transcriptional factors. Part I: Expression of Ah receptor in the C57BL/6N mouse embryo. Dev. Dynam., 204:133-143.
14. Birnbaum, L.S. (1995) Developmental effects of dioxin. Environ. Health Perspect., 103:89-94.
15. Birnbaum, L.S., and B.D. Abbott (1997) Effect of dioxin on growth factor and receptor expression in developing palate. In: Methods in Developmental Toxicology and Biology. S. Klug and R. Theil, eds. Malden, MA: Blackwell Science, Ltd., pp. 51-63.
16. Brunet, C.L., P.M. Sharpe, and M.W.J. Ferguson (1995) Inhibition of TGF-β3 (but not TGF-β1 or TGFβ2) activity prevents normal mouse embryonic palate fusion. Int. J. Dev. Biol., 39:345-355.
17. Burbach, K.M., A. Poland, and C.A. Bradfield (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc. Natl. Acad. Sci. USA, 89:8185-8189.
18. Choi, E.J., D.G. Toscano, J.A. Ryan, N. Reidel, and W.A. Toscano (1991) Dioxin induces transforming growth factor-α in human kerationcytes. J. Biol. Chem., 266:9591-9597.
19. Citterio, H.L. and D.A. Gaillard (1994) Expression of transforming growth factor alpha (TGFα), epidermal growth factor receptor (EGF-R) and cell proliferation during human palatogenesis: An immunohistochemical study. Int. J. Dev. Biol., 38:499-505.
20. Costa, A., M.P. Rocci, R. Arisio, C. Benedetto, C. Fabris, E. Bertino, G. Botta, L. Marozio, M. Mostert, D. Urbano, and A. Emanuel (1996) Glucocorticoid receptors immunoreactivity in tissue of human embryos. J. Endocrinol. Invest., 19:92-98.
21. Couture, L.A., B.D. Abbott, and L.S. Birnbaum (1990) A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Recent advances toward understanding the mechanism. Teratology, 42:619-627.
22. Derynck, R., J.A. Jarrett, E.Y. Chen, D.H. Eaton, J.R. Bell, R.K. Assoian, A.B. Roberts, M.B. Sporn, and D.V. Goeddel (1985) Human transforming growth factor-α complementary DNA sequence and expression in normal and transformed cells. Nature, 316:701-705.
23. Fitzpatrick, D.R, F. Denhez, P. Kondaiah, and R.J. Akhurst (1990) Differential expression of TGF beta isoforms in murine palatogenesis. Development, 109:585-595.
24. Gaido, K.W., and S.C. Maness (1994) Regulation of gene expression and acceleration of differentiation in human keratinocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol., 127:199-208.
25. Gaido, K.W., S.C. Maness, L.S. Leonard, and W.F. Greenlee (1992) 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-α and -β2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control. J. Biol. Chem., 267:24591-24595.
26. Gheris, A.L., M. D'Angelo, and R.M. Greene (1991) Immunodetection of the transforming growth factors β1 and β2 in the developing murine palate. Int. J. Dev. Biol., 35:17-24.
27. Hoffman, E.C., H. Reyes, F.-F. Chu, F. Sander, L.H. Conley, B.A. Brooks, and O. Hankinson (1991) Cloning of a factor required for activity of the Ah (dioxin) receptor. Science, 252:954-958.
28. Hord, N.G., and G.H. Perdew (1994) Physicochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocator: Characterization of two monoclonal antibodies to the aryl hydrocarbon receptor nuclear translocator. Mol. Pharmacol., 46:618-626.
29. Kong, F.-M., M.S. Anscher, T. Murase, B.D. Abbott, J.D. Igelhart, and R.L. Jirtle (1995) Elevated plasma TGFβ1 levels in breast cancer patients decrease following surgery: A possible tumor marker. Ann. Surg., 222:155-162.
30. Lee, D.C., K.D. Barlow, and K.W. Gaido (1996) The actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin on transforming growth factor-β2 promoter activity are localized to the TATA box binding region and controlled through a tyrosine kinase-dependent pathway. Toxicol. Appl. Pharmacol., 137:90-99.
31. MacKay, K., P. Kondaiah, D. Danielpour, H.A. Austin III, and P.D. Brown (1990) Expression of transforming growth factor-β1 and β2 in rat glomeruli. Kidney Int., 38:1095-1100.
32. Miesfeld, R., S. Rusconi, P.J. Godowski, B.A. Maler, S. Okret, A.-C. Wikstrom, J.-A. Gustafson, and K.R. Yamamoto (1986) Genetic complementation of a glucocorticoid receptor deficiency by expression of a cloned receptor cDNA. Cell, 46:389-399.
33. Pelton, R.W., B.L. Hogan, D.A. Miller, and H.L. Moses (1990) Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation. Devl. Biol., 147:456-460.
34. Perdew, G.H. (1992) Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7. Biochem. Biophys. Res. Commun., 182:55-62.
35. Perdew, G.H., B. Abbott, and L.H. Stanker (1995) Production and characterization of monoclonal antibodies directed against the Ah receptor. Hybridoma, 14:279-283.
36. Probst, M.R., S. Reisz-Porszasz, R.V. Agbunag, M.S. Ong, and O. Hankinson (1993) Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Molec. Pharmacol. 44:511-518.
37. Proetzel, G., S.A. Pawlowski, M.V. Wiles, M. Yin, G.P. Boivin, P.N. Howles, J. Ding, M.W.J. Ferguson, and T. Doetschman (1995) Transforming growth factor-β3 is required for secondary palate fusion. Nat. Genet., 11:409-414.
38. SAS Institute, Inc. (1989) SAS/STAT User's Guide: Version 6, Volume 2. Cary, NC: SAS Institute, Inc.
39. SAS Institute, Inc. (1996) SAS/STAT Software: Changes and Enhancements for Release 6.12. Cary, NC: SAS Institute, Inc.
40. Schmidt, J.V., and C.A. Bradfield (1996) AH receptor signaling pathways. Annu. Rev. Cell Dev. Biol., 12:55-89.
41. Vogel, C., and J. Abel (1995) Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on growth factor expression in the human breast cancer cell line MCF-7. Arch. Toxicol., 69:259-265.
42. Zimmerman. E.F. (1997) Palate. In: Handbook of Experimental Pharmacology 124/I: Drug Toxicity in Embryonic Development I. R.J. Kavlock and G.P. Daston, eds. New York: Springer-Verlag, pp. 183-208.