Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat

Journal of Physiology

Volumn 564, Issue 2, 2005, Pages 619-630

  Brown, David A ^a   Lynch, Joshua M ^a   Armstrong, Casey J ^a   Caruso, Nicholas M ^a   Ehlers, Lindsay B ^a   Johnson, Micah S ^a   Moore, Russell L ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; MANGANESE SUPEROXIDE DISMUTASE; POTASSIUM CHANNEL; PROTEIN SUBUNIT; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PROTEIN SUR2A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DATA ANALYSIS; DISEASE PREDISPOSITION; FEMALE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYPEREMIA; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RUNNING; SARCOLEMMA; SEX DIFFERENCE; STATISTICAL ANALYSIS; TREADMILL EXERCISE; CORONARY ARTERY DISEASE; CORONARY VASCULAR HYPEREMIA; HEART INFARCTION; HEART MUSCLE FIBER MEMBRANE; KINESIOTHERAPY; THERAPY EFFECT; TREADMILL;

ANIMALS; DISEASE SUSCEPTIBILITY; FEMALE; MALE; MYOCARDIAL REPERFUSION INJURY; PHYSICAL CONDITIONING, ANIMAL; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; SUPEROXIDE DISMUTASE;

EID: 17844377994     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.081323     Document Type: Article

References (40)

1. Barp J, Araujo AS, Fernandes TR, Rigatto KV, Llesuy S, Bello-Klein A et al. (2002). Myocardial antioxidant and oxidative stress changes due to sex hormones. Braz J Med Biol Res 35, 1075-1081.
2. Bolli R (2000). The late phase of preconditioning. Circ Res 87, 972-983.
3. Bowles DK, Farrar RP & Starnes JW (1992). Exercise training improves cardiac function after ischemia in the isolated, working rat heart. Am J Physiol 263, H804-H809.
4. Bowles DK & Starnes JW (1994). Exercise training improves metabolic response after ischemia in isolated working rat heart. J Appl Physiol 76, 1608-1614.
5. Brandes RP & Mugge A (1997). Gender differences in the generation of superoxide anions in the rat aorta. Life Sci 60 391-396.
6. Brown DA, Jew KN, Sparagna GC, Musch TI & Moore RL (2003). Exercise training preserves coronary flow and reduces infarct size following ischemia-reperfusion in rat heart. J Appl Physiol 95 2510-2518.
7. ATP channels. Circ Res 89, 273-278.
8. 1 receptor activation induces delayed preconditioning in rats mediated by manganese superoxide dismutase. Circulation 101, 2841-2848.
9. Demirel HA, Powers SK, Zergeroglu MA, Shanely RA, Hamilton K, Coombes J et al. (2001). Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. J Appl Physiol 91, 2205-2212.
10. + channels. FASEB J 12, 523-529.
11. Furuya K & Chaudhuri G (1993). Estradiol does not influence myocardial superoxide dismutase activity in rabbits. J Cardiovasc Pharmacol 22, 65-68.
12. Gross GJ & Auchampach JA (1992). Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.Circ Res 70, 223-233.
13. ATP channels and myocardial preconditioning: an update. Am J Physiol Heart Circ Physiol 285 H921-H930.
14. Gumina RJ, Pucar D, Bast P, Hodgson DM, Kurtz CE, Dzeja PP et al. (2003). Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. Am J Physiol Heart Circ Physiol 284, H2106-H2113.
15. Hamilton KL, Powers SK, Sugiura T, Kim S, Lennon S, Tumer N et al. (2001). Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins. Am J Physiol Heart Circ Physiol 281, H1346-H 1352.
16. Hamilton KL, Staib JL, Phillips T, Hess A, Lennon SL & Powers SK (2003). Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion. Free Radic Biol Med 34, 800-809.
17. Inagaki N, Gonoi T, Clement J, Pt Namba N, Inazawa J, Gonzalez G et al. (1995). Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270 1166-1170.
18. Jew KN & Moore RL (2001). Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats. J Appl Physiol 91, 1545-1554.
19. Jew KN & Moore RL (2002). Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes. J Appl Physiol 92, 1473-1479.
20. Laughlin MH, Oltman CL & Bowles DK (1998). Exercise training-induced adaptations in the coronary circulation. Med Sci Sports Exerc 30, 352-360.
21. Laughlin MH, Rubin LJ, Rush JW, Price EM, Schrage WG & Woodman CR (2003a). Short-term training enhances endothelium-dependent dilation of coronary arteries, not arterioles. J Appl Physiol 94, 234-244.
22. Laughlin MH, Welshons WV, Sturek M, Rush JW, Turk JR, Taylor JA et al. (2003b). Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries. J Appl Physiol 95, 250-264.
23. + channels in canine hearts. J Mol Cell Cardiol 32, 1147-1158.
24. Li Y & KJoner RA (1995). Is there a gender difference in infarct size and arrhythmias following experimental coronary occlusion and reperfusion? J Thromb Thrombolysis 2, 221-225.
25. Manfroi WC, Peukert C, Berti CB, Noer C, Gutierres Dde A & Silva FT (2002). Acute myocardial infarction: the first manifestation of ischemic heart disease and relation to risk factors. Arq Bras Cardiol 78, 392-395.
26. McNulty PH, Jagasia D, Whiting JM & Caulin-Glaser T (2000). Effect of 6-wk estrogen withdrawal or replacement on myocardial ischemic tolerance in rats. Am J Physiol Heart Circ Physiol 278, H1030-H1034.
27. Morris JN, Everitt MG, Pollard R, Chave SP & Semmence AM (1980). Vigorous exercise in leisure-time: protection against coronary heart disease. Lancet 2, 1207-1210.
28. ATP channels in preconditioning. Circ Res 87, 845-855.
29. Paroo Z, Haist JV, Karmazyn M & Noble EG (2002). Exercise improves postischemic cardiac function in males but not females: consequences of a novel sex-specific heat shock protein 70 response. Circ Res 90, 911-917.
30. Powers SK, Demirel HA, Vincent HK, Coombes JS, Naito H, Hamilton KL et al. (1998). Exercise training improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. Am J Physiol 275, R1468-RR1468-R1477.
31. Przyklenk K, Ovize M, Bauer B & Kloner RA (1995). Gender does not influence acute myocardial infarction in adult dogs. Am Heart J 129, 1108-1113.
32. + channels. J Am Coll Cardiol 38, 906-915.
33. Sbarouni E, Iliodromitis EK, Bofilis E, Kyriakides ZS & Kremastinos DT (1998). Short-term estrogen reduces myocardial infarct size in oophorectomized female rabbits in a dose-dependent manner. Cardiovasc Drugs Ther 12, 457-462.
34. Sbarouni E, Iliodromitis EK, Bofilis E, Kyriakides ZS & Kremastinos DT (2003). Estrogen alone or combined with medroxyprogesterone but not raloxifene reduce myocardial infarct size. Eur J Pharmacol 467, 163-168.
35. Starnes JW, Taylor RP & Park Y (2003). Exercise improves postischemic function in aging hearts. Am J Physiol Heart Circ Physiol 285, H347-H351.
36. World Health Organization (2003). Facts and figures. The World Health Report 2003, pp. 1-6. World Health Organization.
37. Yamashita N, Baxter GF & Yellon DM (2001). Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism. Heart 85, 331-336.
38. Yamashita N, Hoshida S, Otsu K, Asahi M, Kuzuya T & Hori M (1999). Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation. J Exp Med 189, 1699-1706.
39. Yamashita N, Hoshida S, Otsu K, Taniguchi N, Kuzuya T & Hori M (2000). Involvement of cytokines in the mechanism of whole-body hyperthermia-induced cardioprotection. Circulation 102, 452-457.
40. Yellon DM & Downey JM (2003). Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 83 1113-1151.