Exercise improves postischemic cardiac function in males but not females: Consequences of a novel sex-specific heat shock protein 70 response

Circulation Research

Volumn 90, Issue 8, 2002, Pages 911-917

  Paroo, Zain ^a   Haist, James V ^c   Karmazyn, Morris ^c   Noble, Earl G ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c Schulich School of Medicine and Dentistry   (Canada)

Author keywords

Antisense oligonucleotides; Heat shock proteins; Hormones; Sex; Stress

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ESTROGEN; HEAT SHOCK PROTEIN 70;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HEART FUNCTION; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE RELAXATION; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INDUCTION, SYNTHESIS AND MODIFICATION; RAT; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TREADMILL; WESTERN BLOTTING;

ANIMALS; CARDIOTONIC AGENTS; ESTRADIOL; EXERCISE TEST; EXERTION; FEMALE; HEART; HEAT-SHOCK RESPONSE; HSP70 HEAT-SHOCK PROTEINS; KINETICS; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OLIGONUCLEOTIDES, ANTISENSE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEX FACTORS; TRANS-ACTIVATION (GENETICS); VENTRICULAR DYSFUNCTION, LEFT;

EID: 0037013182     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000016963.43856.B1     Document Type: Article

References (36)

1. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
2. Heat-shock response is associated with enhanced postischemic ventricular recovery
3. Acquisition and decay of heat-shock-enhanced postischemic ventricular recovery
4. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury
5. Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70
6. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery
7. Exercising mammals synthesize stress proteins
8. Can estrogens diminish exercise induced muscle damage?
9. Protection against muscle damage exerted by oestrogen: Hormonal or antioxidant action?
10. Effect of estradiol on tissue glycogen metabolism in exercised oophorectomized rats
11. Normative reproductive indices for male and female adult Sprague-Dawley rats
12. Tamoxifen and oestrogen both protect the rat muscle against physiological damage
13. Neuroprotection against oxidative stress by estrogens: Structure-activity relationship
14. Maximum oxygen consumption of rats and its changes with various experimental procedures
15. Activation of heat-shock transcription factor in rat heart after heat shock and exercise
16. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
17. ATP channels and interaction with the sodium-hydrogen exchange inhibitor HOE 642 (cariporide)
18. Heat shock protein-70 induction mediates luteal regression in the rat
19. Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation
20. Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1
21. Cardiac myocytes and fibroblasts contain functional estrogen receptors
22. Tamoxifen: New membrane-mediated mechanisms of action and therapeutic advances
23. On the path to the heat shock response: Destabilization and formation of partially folded protein intermediates, a consequence of protein thiol modification
24. The protective effects of estrogen on the cardiovascular system
25. Hormone therapy to prevent disease and prolong life in postmenopausal women
26. Women, work and coronary heart disease: Prospective findings from the Framingham heart study
27. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women: Heart and Estrogen/Progestin Replacement Study (HERS) Research Group
28. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis
29. Sex-based differences in early mortality after myocardial infarction: National Registry of Myocardial Infarction 2 Participants
30. Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats
31. Potential repair of rat spinal cord injuries using stimulated homologous macrophages
32. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats
33. In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat
34. Gene therapy for myocardial protection: Transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-reperfusion injury
35. Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury