Exercise interventions for cancer patients: Systematic review of controlled trials

Cancer Causes and Control

Volumn 15, Issue 10, 2004, Pages 1035-1056

  Stevinson, Clare ^a   Lawlor, Debbie A ^a   Fox, Kenneth R ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Cancer; Exercise; Fatigue; Rehabilitation; Walking

Indexed keywords

BODY COMPOSITION; CANCER; CANCER PATIENT; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL TRIAL; DATA BASE; EXERCISE; FATIGUE; HUMAN; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SOCIAL PSYCHOLOGY; CONTROLLED CLINICAL TRIAL; FEMALE; KINESIOTHERAPY; MALE; NEOPLASM;

CONTROLLED CLINICAL TRIALS; EXERCISE THERAPY; FEMALE; HUMANS; MALE; NEOPLASMS;

EID: 17844368113     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-004-1325-4     Document Type: Review

References (120)

1. Jolliffe J, Rees K, Taylor RS, Thompson D, Oldridge N, Abrahim S (2004) Exercise-based rehabilitation for coronary heart disease [Cochrane Review]. The Cochrane Library Issue 2. Oxford: Update Software.
2. Pescatello L, Franklin, BA, Fagard R, Farquhar WB, Kelley GA, Ray CA, American College of Sports Medicine (2004) American College of Sports Medicine position stand. Exercise and hypertension. Med Sci Sports Exerc 36: 533-553.
3. Gordon N, Gulanick M, Costa F, et al., American Heart Association Council on Clinical Cardiology, Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention; the Council on Cardiovascular Nursing; the Council on Nutrition, Physical Activity, and Metabolism; and the Stroke Council (2004) Physical activity and exercise recommendations for stroke survivors. Stroke 35: 1230-1240.
4. Jakicic J, Clark K, Coleman E, et al., American College of Sports Medicine (2001) American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 33: 2145-2156.
5. Albright A, Franz M, Hornsby G, et al. (2000) American College of Sports Medicine position stand. Exercise and type 2 diabetes. Med Sci Sports Exerc 32: 1345-1360.
6. Vuori I (2001) Dose-response of physical activity and low back pain, osteoarthritis, and osteoporosis. Med Sci Sports Exerc 33: S551-S586.
7. Schneider C, Dennehy C, Carter S (2003) Exercise and Cancer Recovery. Champaign, IL: Human Kinetics.
8. Jones L, Courneya KS (2002) Exercise discussions during cancer treatment consultations. Cancer Pract 10: 66-74.
9. Stevinson C, Fox K (2004) Role of exercise for cancer rehabilitation in UK hospitals: a survey of oncology nurses. Eur J Cancer Care (in press).
10. Curt G (2001) Fatigue in cancer. BMJ 322: 1560.
11. Smith S (1996) Physical exercise as an oncology nursing intervention to enhance quality of life. Oncol Nurs Forum 23: 771-778.
12. Thune I, Smeland S (2000) Is physical activity important in treatment and rehabilitation of cancer patients? [Norwegian]. Tidsskr Nor Laegeforen 120: 3302-3304.
13. Pinto B, Maruyama NC (1999) Exercise in the rehabilitation of breast cancer survivors. Psychooncology 8: 191-206.
14. Courneya K, Friedenreich CM (1999) Physical exercise and quality of life following cancer diagnosis: a literature review. Ann Behav Med 21: 171-179.
15. Courneya K, Mackey JR, Jones LW (2000) Coping with cancer: can exercise help? Phys Sportsmed 28: 49-73.
16. Courneya K (2001) Exercise interventions during cancer treatment: biopsychosocial outcomes. Exerc Sport Sci Rev 29: 60-64.
17. Courneya K, Mackey JR, McKenzie DC (2002) Exercise for breast cancer survivors: research evidence and clinical guidelines. Phys Sportsmed 30: 33-42.
18. Sibbald B, Roland M (1998) Why are randomised controlled trials important? BMJ 316: 201.
19. Oldervoll L, Kaasa S, Hjermstad MJ, Lund JA, Loge JH (2004) Physical exercise results in the improved subjective well-being of a few or is effective rehabilitation for all cancer patients? Eur J Cancer 40: 951-962.
20. McManus R, Wilson S, Delaney BC, et al. (1998) Review of the usefulness of contacting other experts when conducting a literature search for systematic reviews. BMJ 317: 1562-1563.
21. Blanchard C, Courneya KS, Laing D (2001) Effects of acute exercise on state anxiety in breast cancer survivors. Oncol Nurs Forum 28: 1617-1621.
22. Schultz I, Barholm M, Grondal S (1997) Delayed shoulder exercises in reducing seroma frequency after modified radical mastectomy: a prospective randomized study. Ann Surg Oncol 4: 293-297.
23. Juni P, Altman G, Egger M (2001) Assessing the quality of controlled clinical trials. BMJ 323: 42-46.
24. Rosenthal R (1994) Parametric measures of effect size. In: Cooper H, Hedges LV, eds. The Handbook of Research Synthesis. New York: Russell Sage Foundation, pp. 231-244.
25. DerSimonian R, Laird N (1986) Meta-regression analysis in clinical trials. Control Clin Trials 7: 177-188.
26. Sterne J, Bradburn MJ, Egger M (2001) Meta-analysis in Stata™. In: Egger M, Davey Smith G, Altman DG, eds. Systematic Reviews in Health Care: Meta-analysis in Context. London: BMA Books, pp. 347-369.
27. Turchetta A, Calzolari A, Donfrancesco A, Drago F, Miano C (1990) Physical activity and competitive sport in youngs with leukemia Off therapy' [abstract]. Proceedings of the World Congress on Sport for All: Tampere, Finland.
28. Whittaker J, Baracos VE, Haennel RG, Brown BE, Humen DP (1991) Exercise training in the posttreatment remission period of patients with limited small cell lung cancer [abstract]. Proceedings of the 24th Annual Meeting of the Canadian Association of Sport Sciences: Kingston, Ontario.
29. Adamsen L, Rasmussen JM, Pedersen LS (2001) 'Brothers in arms': how men with cancer experience a sense of comradeship through group intervention which combines physical activity with information relay. J Clin Nurs 10: 528-537.
30. Decker W, Turner-McGlade JT, Fehir KM (1989) Psychosocial aspects and the physiological effects of a cardiopulmonary exercise program in patients undergoing bone marrow transplantation for acute leukemia. Transplant Proc 21: 3068-3069.
31. Derman W, Coleman KL, Noakes TD (1999) Effects of exercise training in patients with cancer who have undergone chemotherapy [abstract]. 46th Annual Meeting of the American College of Sports Medicine: Seattle. Med Sci Sports Exerc 31: S368.
32. Dimeo F, Bertz H, Finke J, Fetscher S, Mertelsmann R, Keul J (1996) An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplant 18: 1157-1160.
33. Dimeo F, Rumberger G, Keul J (1998) Aerobic exercise as therapy for cancer fatigue. Med Sci Sports Exerc 30: 475-478.
34. Durak E, Lilly PC (1998) The application of an exercise and wellness program for cancer patients: a preliminary outcomes report. J Strength Cond Res 6: 3-6.
35. Durak E, Lilly PC (1999) A 5 year follow-up survey on health and exercise habits in women breast cancer survivors [abstract]. 2nd Annual Meeting of the American Society of Exercise Physiologists: Albuquerque. Breast Cancer Res Treat 57: 92.
36. Durak E, Lilly PC, Hack worth JL (1999) Physical and psychosocial responses to exercise in cancer patients: a two year follow-up survey with postale, leukemia and general carcinoma. J Exerc Physiol Online (http://www.css.edu/users/tboone2/asep/jan12b.htm. Accessed Oct 30, 2002).
37. Gaskin T, LoBuglio A, Kelly P, Doss M, Pizitz N (1989) STRETCH: a rehabilitative program for patients with breast cancer. South Med J 82: 467-469.
38. Kolden G, Strauman TJ, Ward A, et al. (2002) A pilot study of group exercise training (GET) for women with primary breast cancer: feasibility and health benefits. Psychooncology 11: 447-456.
39. Kramer MM (1996) The effects of exercise on psychological well-being in women recovering from breast cancer [abstract]. Diss Abstr Int 57: 2157.
40. Loetzerich H, Peters C, Niemeier B, Schule K, Hoff HG, Uhlenbruck G (1994) Influence of endurance training on natural cytotoxicity and behaviour in cancer patients. Psychologische-Beitraege 36: 47-52.
41. Peters C, Lotzerich H, Niemeier B, Schule K, Uhlenbruck G (1995) Exercise, cancer and the immune response of monocytes. Anticancer Res 15: 175-180.
42. Peters C, Lotzerich H, Niemeier B, Schule K, Uhlenbruck G (1994) Influence of a moderate exercise training on natural killer cytotoxicity and personality traits in cancer patients. Anticancer Res 14: 1033-1036.
43. Peters C (1992) Ausdauersport als Rehabilitationsmassnahme in der Krebsnachsorge: Immunologishce und Psychologische Aspekte [dissertation]. Köln: Deutschen Sporthochschule.
44. Porock D, Kristjanson L, Tinnelly K, Duke T, Blight J (2000) An exercise intervention for advanced cancer patients experiencing fatigue: a pilot study. J Palliat Care 16: 30-36.
45. Schulz K, Szlovak C, Schulz H, et al. (1998) Implementation and evaluation of an exercise rehabilitation training for breast cancer patients [German]. Psychother Psychosom Med Psychol 48: 398-407.
46. Schwartz A (1998) The relationship of exercise to fatigue and quality of life in women with breast cancer [dissertation]. Salt Lake City: University of Utah.
47. Schwartz AL (2000) Exercise and weight gain in breast cancer patients receiving chemotherapy. Cancer Pract 8: 231-237.
48. Schwartz AL, Mori M, Gao R, Nail LM, King ME (2001) Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc 33: 718-723.
49. Schwartz AL (1999) Fatigue mediates the effects of exercise on quality of life. Qual Life Res 8: 529-538.
50. Schwartz AL (2000) Daily fatigue patterns and effect of exercise in women with breast cancer. Cancer Pract 8: 16-24.
51. Sharkey A, Carey AB, Heise CT, Barber G (1993) Cardiac rehabilitation after cancer therapy in children and young adults. Am J Cardiol 71: 1488-1490.
52. Segal R, Reid R, Johnson D, et al. (1996) Pilot study of physical fitness and quality of life in patients with breast cancer [abstract]. 32nd Annual Meeting of the American Society of Clinical Oncology: Philadelphia, Pennsylvania.
53. Yoshioka H (1994) Rehabilitation for the terminal cancer patient. Am J Phys Med Rehabil 73: 199-206.
54. Shore S, Shepard RJ (1999) Immune responses to exercise in children treated for cancer. J Sports Med Phys Fitness 39: 240-243.
55. Earle C, Reid B, Johnson D (1996) Exercise may ameliate the effects of adjuvant breast cancer treatment on physical fitness and quality of life [abstract]. Clin Invest Med 19: 417.
56. Segal R, Reid B, Johnson D (1996) Effects of exercise on body composition in breast cancer patients receiving adjuvant therapy [abstract]. Clin Invest Med 19: 426.
57. Segal R, Reid B, Johnson D (1997) Progressive resistance exercise training in men with advanced prostate cancer [abstract]. Clin Invest Med 20: S58.
58. Segal R, Evans WK, Gayton J, Woodard S, Wells G, Reid, R (2000) Structured exercise improves physical functioning in women with breast cancer (BC): results of a randomized controlled trial [abstract]. Breast Cancer Res Treat 64: 128.
59. Segar M, Katch VL, Roth RS, et al. (1995) Aerobic exercise reduces depression and anxiety, and increases self-esteem among breast cancer survivors [abstract]. Med Sci Sports Exer 27: S212.
60. Seifert E, Ewert S, Werle J (1992) Physical training in the aftercare of patients with cancer of the head and neck [German]. Rehabilitation (Stuttg) 31: 33-37.
61. Durak E, Lilly PC (1999) Preliminary results of exercise in breast cancer: a two year follow up survey. J Rehabil Outcomes Meas 3: 53-60.
62. Lazowski DA, Ecclestone NA, Myers AM, et al. (1999) A randomized outcome evaluation of group exercise programs in long-term care institutions. J Gerontol 54: M621-M628.
63. Pfalzer L (1990) The responses of bone marrow transplant patients to graded exercise testing prior to transplant and after transplant with and without exercise training [dissertation]. Columbus: Ohio State University.
64. Schwartz AL, Thompson JA, Masood N (2002) Interferon-induced fatigue in patients with melanoma: a pilot study of exercise and methylphenidate. Oncol Nurs Forum 29: E85-E90.
65. Petersson LM, Berglund G, Brodin O, Glimelius B, Sjoden PO (2000) Group rehabilitation for cancer patients: satisfaction and perceived benefits. Patient Educ Couns 40: 219-229.
66. Mock V, Pickett M, Ropka ME, et al. (2001) Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract 9: 119-127.
67. Campbell A, Mutrie N, White F, McGuire F, Kearney N (2004) A pilot study of a supervised group exercise program as a rehabilitation treatment for women with breat cancer receiving adjuvant treatment. Eur J Oncol Nurs (in press).
68. Courneya K, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS (2003) Randomized controlled trial of exercise training in post-menopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol 21: 1660-1668.
69. Fairey AS, Courneya KS, Field CJ, Bell GJ, Jones LW, Mackey JR (2003) Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 12: 721-727.
70. Drouin J (2002) Aerobic exercise training effects on physical function, fatigue and mood, immune status, and oxidative stress in subjects undergoing radiation treatment for breast cancer [dissertation]. Detroit: Wayne State University.
71. Galantino ML, Capito L, Kane RJ, Ottey N, Switzer S, Packel L (2003) The effects of Tai Chi and walking on fatigue and body mass index in women living with breast cancer: a pilot study. Rehabil Oncol 21: 17-22.
72. Segal R, Evans W, Johnson D, et al. (2001) Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol 19: 657-665.
73. Segar ML, Katch VL, Roth RS, et al. (1998) The effect of aerobic exercise on self-esteem and depressive and anxiety symptoms among breast cancer survivors. Oncol Nurs Forum 25: 107-113.
74. Mock V, Dow KH, Meares CJ, et al. (1997) Effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer. Oncol Nurs Forum 24: 991-1000.
75. Nieman DC, Cook VD, Henson DA, et al. (1995) Moderate exercise training and natural killer cell cytotoxic activity in breast cancer patients. Int J Sports Med 16: 334-337.
76. Mock V, Burke MB, Sheehan P, et al. (1994) A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy. Oncol Nurs Forum 21: 899-907.
77. MacVicar MG, Winningham ML, Nickel JL (1989) Effects of aerobic interval training on cancer patients' functional capacity. Nurs Res 38: 348-351.
78. Winningham ML, MacVicar MG, Bondoc M, Anderson JI, Minton JP (1989) Effect of aerobic exercise on body weight and composition in patients with breast cancer on adjuvant chemotherapy. Oncol Nurs Forum 16: 683-689.
79. Winningham ML, MacVicar MG (1988) The effect of aerobic exercise on patient reports of nausea. Oncol Nurs Forum 15: 447-450.
80. MacVicar M, Winningham, ML (1986) Promoting the functional capacity of cancer patients. Cancer Bull 38: 235-239.
81. Winningham M (1983) Effects of a bicycle ergometry program on functional capacity and feelings of control in women with breast cancer [dissertation]. Columbus: Ohio State University.
82. Oliver S (2003) Physiological and psychological effects of progressive resistance training in elderly prostate cancer patients undergoing androgen deprivation therapy: a pilot study [dissertation]. Bangor: University of Wales - Bangor.
83. Segal R, Reid RD, Courneya KS, et al. (2003) Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 21: 1653-1659.
84. Berglund G, Petersson L-M, Eriksson KRN, Haggman M (2003) 'Between men': patient perceptions and priorities in a rehabilitation program for men with prostate cancer. Patient Educ Couns 49: 285-292.
85. Courneya K, Friedenreich CM, Sela RA, Quinney A, Rhodes RE, Handman M (2003) The group psychotherapy and home-based physical exercise (GROUP-HOPE) trial in cancer survivors: physical fitness and quality of life outcomes. Psychooncology 12: 357-374.
86. Hayes S, Davies PSW, Parker TW, Bashford J (2003) Total energy expenditure and body composition changes following peripheral blood stem cell transplantation and participation in an exercise programme. Bone Marrow Transplant 31: 331-338.
87. Hayes SC, Rowbottom D, Davies PSW, Parker TW, Bashford J (2003) Immunological changes after cancer treatment and participation in an exercise program. Med Sci Sports Exerc 35: 2-9.
88. Hayes S, Davies PSW, Parker TW, Bashford J, Green A (2004) The role of a mixed type, moderate intensity exercise program following peripheral blood stem cell transplantation. Br J Sports Med 38: 304-309.
89. Hayes S, Davies PSW, Parker TW, Bashford J, Newman B (2004) Quality of life changes following peripheral blood stem cell transplantation and participation in a mixed-type, moderate intensity exercise program. Bone Marrow Transplant 33: 553-558.
90. Burnham TR, Wilcox A (2002) Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc 34: 1863-1867.
91. Mello M, Tanaka C, Dulley FL (2003) Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplant. Bone Marrow Transplant 32: 723-728.
92. Petersson L-M, Nordin K, Glimelius B, Brekkan E, Sjödén P-O, Berglund G (2002) Differential effects of cancer rehabilitation depending on diagnosis and patients cognitive coping style. Psychosom Med 64: 971-980.
93. Dimeo FC, Stieglitz RD, Novelli-Fischer U, Fetscher S, Keul J (1999) Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer 85: 2273-2277.
94. Niesen-Vertommen S (1999) The recovery patterns and effects of exercise rehabilitation on the physiological and psychological health of children who have survived treatment for a malignancy [dissertation]. Vancouver: University of British Columbia.
95. Dimeo FC, Tilmann MH, Bertz H, Kanz L, Mertelsmann R, Keul J (1997) Aerobic exercise in the rehabilitation of cancer patients after high-dose chemotherapy and autologous peripheral stem cell transplantation. Cancer 79: 1717-1722.
96. Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J (1997) Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 90: 3390-3394.
97. Berglund G, Bolund C, Gustavsson U-L, Sjoden P-O (1994) A randomized study of a rehabilitation program for cancer patients: the 'starting again' group. Psychooncology 3: 109-120.
98. Berglund G, Bolund C, Gustafsson UL, Sjoden PO (1994) One-year follow-up of the 'Starting Again' group rehabilitation programme for cancer patients. Eur J Cancer 30: 1744-1751.
99. Berglund G, Bolund C, Gustavsson UL, Sjoden PO (1993) Starting again - a comparison study of a group of rehabilitation program for cancer patients. Acta Oncol 32: 15-21.
100. Buettner L, Gavon SJ (1981) Personality changes and physiological effects of a personalized fitness enrichment program for cancer patients [dissertation]. Bowling Green: Bowling Green State University.
101. Courneya K, Friendenreich CM, Quinney HA, Fields ALA, Jones LW, Fairey AS (2003) A randomised trial of exercise and quality of life in colorectal cancer survivors. Eur J Cancer Care 12: 347-357.
102. Coleman E, Hall-Barrow J, Coon S, Stewart CB (2003) Facilitating exercise adherence for patients with multiple myeloma. Clin J Oncol Nurs 7: 529-535.
103. Coleman E, Coon S, Hall-Barrow J, Richards K, Gaylor D, Stewart CB (2003) Feasibility of exercise during treatment for multiple myeloma. Cancer Nurs 26: 410-419.
104. Wall LM (2000) Changes in hope and power in lung cancer patients who exercise. Nurs Sci Q 13: 234-242.
105. Na YM, Kim MY, Kim YK, Ha YR, Yoon DS (2000) Exercise therapy effect on natural killer cell cytotoxic activity in stomach cancer patients after curative surgery. Arch Phys Med Rehabil 81: 777-779.
106. Cunningham BA, Morris G, Cheney CL, Buergel N, Aker SN, Lenssen P (1986) Effects of resistive exercise on skeletal muscle in marrow transplant recipients receiving total parenteral nutrition. J Parenter Enteral Nutr 10: 558-563.
107. Egger M, Dickersin K, Davey Smith G (2001) Problems and limitations in conducting systematic reviews. In: Egger M, Davey Smith G, Altman DG, eds. Systematic Reviews in Health Care: Meta-analysis in Context, 2nd edn. London: BMJ Publishing Group, pp. 43-68.
108. Easterbrook P, Berlin JA, Gopalan R, Matthews DR (1991) Publication bias in clinical research. Lancet 337: 867-872.
109. Ioannidis JPA (1998) Effect of the statistical signficance of results on the time to completion and publication of randomized efficacy trials. JAMA 279: 281-286.
110. Egger M, Zellweger-Zahner T, Schneider M, Junker C, Lengeier C, Antes G (1997) Language bias in randomised controlled trials published in English and German. Lancet 350: 326-329.
111. Nieminen P, Isohanni M (1999) Bias against European journals in medical publication databases. Lancet 353: 1592.
112. Schulz KF, Chalmers I, Hayes RJ, Altman DG (1995) Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 273: 408-412.
113. Moher D, Pham B, Jones A, et al. (1998) Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 352: 609-613.
114. Hollis S, Campbell F (1999) What is meant by intention to treat analysis? Survey of published randomised controlled trials. BMJ 319: 670-674.
115. Moore R, Gavaghan D, Tramer MR, Collins SL, McQuay HJ (1998) Size is everything - large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects. Pain 78: 209-216.
116. Bland J, Altman DG (1995) Multiple significance tests: the Bonferroni method. BMJ 310: 170-172.
117. Smith D G, Clemens J, Crede W, Harvey M, Gracely EJ (1987) Impact of multiple comparisons in randomized clinical trials. Am J Med 83: 545-550.
118. Dimeo F (2001) Effects of exercise on cancer-related fatigue. Cancer 92: 1689-1693.
119. Alderson P, Roberts I (2000) Should journals publish systematic reviews that find no evidence to guide practice? Examples from injury research. BMJ 320: 376-377.
120. Campbell M, Fitzpatrick, R, Haines, A, et al. (2000) Framework for design and evaluation of complex interventions to improve health. BMJ 321: 694-696.