-
1
-
-
0002145419
-
New technologies in epidermal growth factor receptor-targeted cancer therapy
-
Baselga J. New technologies in epidermal growth factor receptor-targeted cancer therapy. Signal. 1:2000;12-21
-
(2000)
Signal
, vol.1
, pp. 12-21
-
-
Baselga, J.1
-
2
-
-
0001933248
-
The epidermal growth factor receptor (EGFR) - A new target in cancer therapy
-
Wells A. The epidermal growth factor receptor (EGFR) - a new target in cancer therapy. Signal. 1:2000;4-11
-
(2000)
Signal
, vol.1
, pp. 4-11
-
-
Wells, A.1
-
3
-
-
0033757709
-
Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy
-
Raymond E., Faivre S., Armand J.P. Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy. Drugs. 60:(Suppl 1):2000;15-23
-
(2000)
Drugs
, vol.60
, Issue.SUPPL. 1
, pp. 15-23
-
-
Raymond, E.1
Faivre, S.2
Armand, J.P.3
-
5
-
-
0028800035
-
Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors
-
Moscatello D.K., Holgado-Madruga M., Godwin A.K., et al. Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors. Cancer Res. 55:1995;5536-5539
-
(1995)
Cancer Res
, vol.55
, pp. 5536-5539
-
-
Moscatello, D.K.1
Holgado-Madruga, M.2
Godwin, A.K.3
-
6
-
-
1842626080
-
Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer
-
Olapade-Olaopa E.O., Moscatello D.K., MacKay E.H., et al. Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer. Br J Cancer. 82:2000;186-194
-
(2000)
Br J Cancer
, vol.82
, pp. 186-194
-
-
Olapade-Olaopa, E.O.1
Moscatello, D.K.2
MacKay, E.H.3
-
7
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F., Caputo R., Bianco R., et al. Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res. 7:2001;1459-1465
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
-
8
-
-
0034799139
-
A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor
-
Ciardiello F., Tortora G. A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res. 7:2001;2958-2970
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2958-2970
-
-
Ciardiello, F.1
Tortora, G.2
-
9
-
-
5344229422
-
-
Inhibition of P21-activated kinase 1, directional cell motility and invasion of growth-factor-activated human cancer cells by the selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa'). Poster presentation. San Francisco :April 6-10. (poster 786)
-
Mandal M., Adam L., Wang R.-A., et al. Inhibition of P21-activated kinase 1, directional cell motility and invasion of growth-factor-activated human cancer cells by the selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa'). Poster presentation at the AACR. San Francisco :April 6-10, 2002;. (poster 786)
-
(2002)
AACR
-
-
Mandal, M.1
Adam, L.2
Wang, R.-A.3
-
10
-
-
0034068319
-
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
-
Ciardiello F., Caputo R., Bianco R., et al. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res. 6:2000;2053-2063
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2053-2063
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
-
11
-
-
0000238822
-
Potentiation of cytotoxic agents against human tumors in mice by ZD1839 (Iressa™), an inhibitor of EGFR tyrosine kinase, does not require high levels of expression of EGFR
-
(abstract 3076)
-
Sirotnak F.M., Zakowsky M.F., Miller V.A., Scher H.I., Kris M.G. Potentiation of cytotoxic agents against human tumors in mice by ZD1839 (Iressa™), an inhibitor of EGFR tyrosine kinase, does not require high levels of expression of EGFR. Proc Am Assoc Cancer Res. 41:2000;482. (abstract 3076)
-
(2000)
Proc Am Assoc Cancer Res
, vol.41
, pp. 482
-
-
Sirotnak, F.M.1
Zakowsky, M.F.2
Miller, V.A.3
Scher, H.I.4
Kris, M.G.5
-
12
-
-
0037673681
-
Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumours
-
Nakagawa K., Tamura T., Negoro S., et al. Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumours. Ann Oncol. 14:2003;922-930
-
(2003)
Ann Oncol
, vol.14
, pp. 922-930
-
-
Nakagawa, K.1
Tamura, T.2
Negoro, S.3
-
13
-
-
0036842170
-
Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
-
Baselga J., Rischin D., Ranson M., et al. Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol. 20:2002;4292-4302
-
(2002)
J Clin Oncol
, vol.20
, pp. 4292-4302
-
-
Baselga, J.1
Rischin, D.2
Ranson, M.3
-
14
-
-
0036569870
-
ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
-
Ranson M., Hammond L.A., Ferry D., et al. ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J Clin Oncol. 20:2002;2240-2250
-
(2002)
J Clin Oncol
, vol.20
, pp. 2240-2250
-
-
Ranson, M.1
Hammond, L.A.2
Ferry, D.3
-
15
-
-
0037106377
-
Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a phase I trial
-
Herbst R.S., Maddox A.M., Rothenberg M.L., et al. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. J Clin Oncol. 20:2002;3815-3825
-
(2002)
J Clin Oncol
, vol.20
, pp. 3815-3825
-
-
Herbst, R.S.1
Maddox, A.M.2
Rothenberg, M.L.3
-
16
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
Fukuoka M., Yano S., Giaccone G., et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol. 21:2003;2237-2246
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
17
-
-
0001303063
-
A phase II trial of ZD1839 ('Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2)
-
(abstract 1166)
-
Kris M.G., Natale R.B., Herbst R.S., et al. A phase II trial of ZD1839 ('Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2). Proc Am Soc Clin Oncol. 21:2002;292a. (abstract 1166)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
18
-
-
0242668485
-
Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib ('Iressa', ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2
-
(abstract LB-170)
-
Bailey L.R., Kris M., Wolf M., et al. Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib ('Iressa', ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2. Proc Am Assoc Cancer Res. 44:2003;. (abstract LB-170)
-
(2003)
Proc Am Assoc Cancer Res
, vol.44
-
-
Bailey, L.R.1
Kris, M.2
Wolf, M.3
-
19
-
-
0346031809
-
Interobserver reproducibility of visually interpreted EGFR immunohistochemical staining in non-small-cell lung cancer
-
(abstract LB-213)
-
Janas M.S., Franklin W.A., Schmidt K., Bailey L.R. Interobserver reproducibility of visually interpreted EGFR immunohistochemical staining in non-small-cell lung cancer. Proc Am Assoc Cancer Res. 44:2003;. (abstract LB-213)
-
(2003)
Proc Am Assoc Cancer Res
, vol.44
-
-
Janas, M.S.1
Franklin, W.A.2
Schmidt, K.3
Bailey, L.R.4
-
20
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature. 411:2001;355-365
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
21
-
-
0026316096
-
Growth factors and cancer
-
Aaronson S.A. Growth factors and cancer. Science. 254:1991;1146-1153
-
(1991)
Science
, vol.254
, pp. 1146-1153
-
-
Aaronson, S.A.1
-
22
-
-
0347910287
-
Quantitative gene expression in non-small cell lung cancer from paraffin-embedded tissue specimens: Predicting response to gefitinib, an EGFR kinase inhibitor
-
(abstract 763)
-
Natale R.B., Shak S., Aronson N., et al. Quantitative gene expression in non-small cell lung cancer from paraffin-embedded tissue specimens: Predicting response to gefitinib, an EGFR kinase inhibitor. Proc Am Soc Clin Oncol. 22:2003;190. (abstract 763)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 190
-
-
Natale, R.B.1
Shak, S.2
Aronson, N.3
-
23
-
-
5344236093
-
Identification of genes associated with sensitivity to the EGFR tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer cell lines and tumor xenografts
-
(abstract 3773)
-
Suzuki C., Daigo Y., Kakiuchi S., Zembutzu H., Furukawa C., Nakamura Y. Identification of genes associated with sensitivity to the EGFR tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer cell lines and tumor xenografts. Proc Am Assoc Cancer Res. 44:2003;. (abstract 3773)
-
(2003)
Proc Am Assoc Cancer Res
, vol.44
-
-
Suzuki, C.1
Daigo, Y.2
Kakiuchi, S.3
Zembutzu, H.4
Furukawa, C.5
Nakamura, Y.6
-
24
-
-
0036384579
-
Prognostic factors in non-small cell lung cancer. A decade of progress
-
Brundage M.D., Davies D., Mackillop W.J. Prognostic factors in non-small cell lung cancer. A decade of progress. Chest. 122:2002;1037-1057
-
(2002)
Chest
, vol.122
, pp. 1037-1057
-
-
Brundage, M.D.1
Davies, D.2
MacKillop, W.J.3
-
25
-
-
0034329630
-
Second-line chemotherapy in relapsing or refractory non-small-cell lung cancer: A review
-
Huisman C., Smit E.F., Giaccone G., Postmus P.E. Second-line chemotherapy in relapsing or refractory non-small-cell lung cancer: a review. J Clin Oncol. 18:2000;3722-3730
-
(2000)
J Clin Oncol
, vol.18
, pp. 3722-3730
-
-
Huisman, C.1
Smit, E.F.2
Giaccone, G.3
Postmus, P.E.4
-
26
-
-
5344270545
-
-
Results of a multivariate analysis of prognostic factors for overall survival of patients with advanced non-small-cell lung cancer treated with gefitinib ('Iressa', ZD1839) in combination with platinum-based chemotherapy in two large phase III trials (INTACT 1 and INTACT 2). Poster presentation. Chicago, IL, USA :May 31-June 3, (poster 2522)
-
Giaccone G., Johnson D., Scagliotti G.V., et al. Results of a multivariate analysis of prognostic factors for overall survival of patients with advanced non-small-cell lung cancer treated with gefitinib ('Iressa', ZD1839) in combination with platinum-based chemotherapy in two large phase III trials (INTACT 1 and INTACT 2). Poster presentation at ASCO. Chicago, IL, USA :May 31-June 3, 2003;. (poster 2522)
-
(2003)
ASCO
-
-
Giaccone, G.1
Johnson, D.2
Scagliotti, G.V.3
-
27
-
-
0037674062
-
Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
-
Cohen E.E.W., Rosen F., Stadler W.M., et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 21:2003;1980-1987
-
(2003)
J Clin Oncol
, vol.21
, pp. 1980-1987
-
-
Cohen, E.E.W.1
Rosen, F.2
Stadler, W.M.3
-
28
-
-
5344266105
-
Clinical benefits in patients with advanced non-small-cell lung cancer treated with gefitinib in the compassionate use programme
-
Abstract presented. Vancouver, Canada :August 10-14. (abstract O-243)
-
Jänne P.A., Gurubhagavatula S., Lucca J., et al. Clinical benefits in patients with advanced non-small-cell lung cancer treated with gefitinib in the compassionate use programme. Abstract presented at the 10th WCLC. Vancouver, Canada :August 10-14, 2003;. (abstract O-243)
-
(2003)
10th WCLC
-
-
Jänne, P.A.1
Gurubhagavatula, S.2
Lucca, J.3
-
29
-
-
0000329007
-
A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small-cell lung cancer (NSCLC)
-
(abstract 1235)
-
Perez-Soler R., Chachoua A., Huberman M., et al. A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small-cell lung cancer (NSCLC). Proc Am Soc Clin Oncol. 20:2001;310a. (abstract 1235)
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Perez-Soler, R.1
Chachoua, A.2
Huberman, M.3
-
30
-
-
0003241755
-
Final report of the efficacy and safety of the anti-epidermal growth factor antibody Erbitux (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck to cisplatin containing chemotherapy
-
(abstract 925)
-
Kies M.S., Arquette M.A., Nabell L. Final report of the efficacy and safety of the anti-epidermal growth factor antibody Erbitux (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck to cisplatin containing chemotherapy. Proc Am Soc Clin Oncol. 21:2002;232a. (abstract 925)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Kies, M.S.1
Arquette, M.A.2
Nabell, L.3
-
31
-
-
0011516690
-
Initial results from a Phase II trial of ZD1839 ('Iressa') as second- and third-line monotherapy for patients with advanced non-small-cell lung cancer (IDEAL 1)
-
Poster presentation. Miami Beach, Florida, USA :October 29-November 2. (poster 630A)
-
Baselga J., Yano S., Giaccone G., et al. Initial results from a Phase II trial of ZD1839 ('Iressa') as second- and third-line monotherapy for patients with advanced non-small-cell lung cancer (IDEAL 1). Poster presentation at the AACR-NCI-EORTC. Miami Beach, Florida, USA :October 29-November 2, 2001;. (poster 630A)
-
(2001)
AACR-NCI-EORTC
-
-
Baselga, J.1
Yano, S.2
Giaccone, G.3
-
32
-
-
0036139727
-
Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
-
Albanell J., Rojo F., Averbuch S., et al. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. J Clin Oncol. 20:2002;110-124
-
(2002)
J Clin Oncol
, vol.20
, pp. 110-124
-
-
Albanell, J.1
Rojo, F.2
Averbuch, S.3
|