Hyperandrogenism in the adolescent female

Steroids

Volumn 63, Issue 5-6, 1998, Pages 308-313

  Toscano, Vincenzo ^a   Balducci, Rina ^b   Mangiantini, Adele ^b   Falasca, Paolo ^a   Sciarra, Francesco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Hirsufism; Precocious pubarche; Prepubertal hypertrichosis

Indexed keywords

ANDROSTENEDIONE; FOLLITROPIN; HYDROCORTISONE; HYDROXYPROGESTERONE; LUTEINIZING HORMONE; PRASTERONE SULFATE; SPIRONOLACTONE; STEROID 21 MONOOXYGENASE; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE;

ADOLESCENT; ADULT; AMENORRHEA; ANDROGEN BLOOD LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FEMALE INFERTILITY; HIRSUTISM; HUMAN; HYPERANDROGENISM; MAJOR CLINICAL STUDY; OLIGOMENORRHEA; OVARY POLYCYSTIC DISEASE; PRECOCIOUS PUBERTY; RISK FACTOR; STEROID 21 MONOOXYGENASE DEFICIENCY;

ADOLESCENT; AMENORRHEA; CHILD; FEMALE; HIRSUTISM; HUMANS; HYPERANDROGENISM; PROGNOSIS; PROSPECTIVE STUDIES; PUBERTY, PRECOCIOUS; RETROSPECTIVE STUDIES;

EID: 17744420628     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(98)00032-4     Document Type: Conference Paper

References (26)

1. 1. Rittmaster RS (1997). Hirsutism. Lancet 349:191-195.
2. 2. Toscano V (1991). Hirsutism: Pilosebaceous unit dysregulation. Role of peripheral and glandular factors. J Endocrinol Invest 14: 153-170.
3. 3. Franks S (1995). Medical progress: Polycystic ovary syndrome. New Engl J Med 333:853-861.
4. 4. Rosenfeld RL (1997). Is polycystic ovary syndrome a neuroendocrine or an ovarian disorder? Clin Endocr (Oxf) 47:423-424.
5. 5. Gilling-Smith C, Story H, Rogers V, Franks S (1997). Evidence for a primary abnormality of techal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocr (Oxf) 47:93-99.
6. 6. Balducci R, Boscherini B, Mangiantini A, Morellini M, Toscano V (1994). Isolated precocious pubarche: An approach. J Clin Endocrinol Metab 79:582-589.
7. 7. Temeck JV, Pang S, Nelson C, New MI (1987). Genetic defects of steroidogenesis in premature pubarche. J Clin Endocr Metab 64: 609-617.
8. 8. Balducci R, Toscano V (1990). Bioactive and peripheral androgens in prepubertal simple hypertrichosis. Clin Endocr (Oxf) 33:407-414.
9. 9. Toscano V, Bianchi P, Balducci R, Guglielmi R, Mangiantini A, Lubrano C, Sciarra F (1992). Lack of linear relationship between hyperinsulinemia and hyperandrogenism. Clin Endocr (Oxf) 36: 197-202.
10. 10. Ibanez L, Potau N, Zampolli M, Riquè S, Saenger P, Carrascosa A (1997). Hyperinsulinemia and decreased insulin-like-growth-factor-binding protein-1 are common features in prepubertal and pubertal girls with a history of premature pubarche. J Clin Endocrinol Metab 82:2283-2288.
11. 11. Ibanez L, Virdis R, Potau N, Zampolli M, Ghizzoni L, Albisu MA, Carrascosa A, Bernasconi S, Vicens-Calvet E (1992). Natural history of premature pubarche: An auxological study. J Clin Endocrinol Metab 74:254-257.
12. 12. Ibanez L, Potau N, Zampolli M, Street M, Carrascosa A (1997). Girls diagnosed with premature pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty: Evidence from gonadotropin-releasing hormone agonist testing. Fertil Steril 67:849-855.
13. 13. Allen SE, Potter HD, Azziz R (1997). Prevalence of hyperandrogenemia among nonhirsute oligo-ovulatory women. Fertil Steril 67:569-572.
14. 14. Yen SS C (1986). Chronic anovulation caused by peripheral endocrine disorders. In: Yen SS C, Jaffe RB (Eds), Reproductive Endocrinology II edition. W B Saunders, Philadelphia, pp 441-499.
15. 15. Saenger P (1992). Editorial. Premature adrenarche: A normal variant of puberty? J Clin Endocrinol Metab 74:236-238.
16. 16. Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA (1989). Pituitary-ovarian responses to naferelin testing in the polycystic ovary syndrome. New Engl J Med 320:559-565.
17. 17. Ehrmann DA, Rosenfield RL, Barnes RB, Brigell DF, Sheikh Z (1992). Detection of functional ovarian hyperandrogenism in women with androgen excess. New Engl J Med 327:157-162.
18. 18. Rosenfield RL, Barnes RB, Ehrmann DA (1994). Studies on the nature of 17-hydroxyprogesterone hyperresponsiveness to gonatrodopin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 79:1686-1692.
19. 19. Loughlin T, Cunningham S, Moore A, Smith P, McKenna T (1986). Adrenal abnormalities in polycystic ovary syndrome. J Clin Endocrinol Metab 62:142-147.
20. 20. Bianchi P, Toscano V, Monaco G, Marano G, Lubrano C, Sciarra F (1993). Effects of ACTH, insulin, insulin-like growth factor 1 on guinea pig adrenals fasciculata-glomerulosa cells. J Endocrinol Invest 16:88 (Abstract).
21. 21. Rosenfield RL (1996). Editorial: Evidence that idiopathic functional adrenal hyperandrogenism is caused by dysregulation of adrenal steroidogenesis and that hyperinsulinemia may be involved. J Clin Endocrinol Metab 81:878-880.
22. 22. Moghetti P, Castello R, Negri C, Tosi F, Spiazzi GG, Brun E, Balducci R, Toscano V, Muggeo M (1996). Insulin infusion amplifies 17α-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: Apparent relative impairment of 17,20-lyase activity. J Clin Endocrinol Metab 81:881-886.
23. 23. Toscano V, Adamo MV, Caiola S, Foli S, Petrangeli E, Casilli D, Sciarra F (1983). Is hirsutism an evolving syndrome? J Endocrinology 97:379-387.
24. 24. Toscano V, Balducci R, Bianchi P, Guglielmi R, Mangiantini A, Sciarra F (1992). Steroidal and non-steroidal factors in plasma sex hormone binding globulin regulation. J Steroid Biochem Mol Biol 43:431-437.
25. 25. Moghetti P, Tosi F, Castello R, Magnani C M, Negri C, Brun E, Furlani L, Caputo M, Muggeo M (1996). The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: Evidence that androgens impair insulin action in women. J Clin Endocrinol Metab 81:952-960.
26. 26. Darendeliler F, Bas F, Balaban S, Bundak R, Demirkol R, Saka N, Gunoz H (1996). Spironolactone therapy in hypertrichosis. Eur J Endocrinol 135:604-608.