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Volumn 44, Issue 6, 1998, Pages 428-432

Inositol levels are decreased in postmortem brain of schizophrenic patients

Author keywords

Inositol levels; Postmortem brain; Schizophrenic patients

Indexed keywords

INOSITOL; LITHIUM; MYOINOSITOL 1 PHOSPHATE SYNTHASE;

EID: 0032530495     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00071-7     Document Type: Article
Times cited : (37)

References (36)
  • 3
    • 0030220460 scopus 로고    scopus 로고
    • Inositol monophosphatase, the putative therapeutic target for lithium
    • Atack J.R. Inositol monophosphatase, the putative therapeutic target for lithium. Brain Res Rev. 22:1996;183-190.
    • (1996) Brain Res Rev , vol.22 , pp. 183-190
    • Atack, J.R.1
  • 4
    • 0032171218 scopus 로고    scopus 로고
    • Behavioral reversal of lithium effects by four inositol isomers correlates perfectly with biochemical effects on the PI cycle; depletion by chronic lithium of brain inositol is specific to hypothalamus; and inositol levels may be abnormal in post-mortem brain for bipolar patients
    • (in press)
    • Belmaker RH, Agam G, van Calker D, Richards MH, Kofman O (in press): Behavioral reversal of lithium effects by four inositol isomers correlates perfectly with biochemical effects on the PI cycle; depletion by chronic lithium of brain inositol is specific to hypothalamus; and inositol levels may be abnormal in post-mortem brain for bipolar patients. Neuropsychopharmacology.
    • Neuropsychopharmacology
    • Belmaker, R.H.1    Agam, G.2    Van Calker, D.3    Richards, M.H.4    Kofman, O.5
  • 5
    • 0029069839 scopus 로고
    • Inositol treatment for panic disorder: A double-blind placebo-controlled crossover trial
    • Benjamin J., Levine J., Fux M., Aviv A., Levy D., Belmaker R.H. Inositol treatment for panic disorder A double-blind placebo-controlled crossover trial . Am J Psychiatry. 152:1995;1084-1086.
    • (1995) Am J Psychiatry , vol.152 , pp. 1084-1086
    • Benjamin, J.1    Levine, J.2    Fux, M.3    Aviv, A.4    Levy, D.5    Belmaker, R.H.6
  • 6
    • 0024341795 scopus 로고
    • Neural and developmental action of lithium: A unifying hypothesis
    • Berridge M.J., Downes C.P., Hanley R.R. Neural and developmental action of lithium A unifying hypothesis . Cell. 59:1989;411-419.
    • (1989) Cell , vol.59 , pp. 411-419
    • Berridge, M.J.1    Downes, C.P.2    Hanley, R.R.3
  • 7
    • 0028854590 scopus 로고
    • Severity of symptoms in chronically institutionalized geriatric schizophrenic patients
    • Davidson M., Harvey P.D., Powchik P., et al. Severity of symptoms in chronically institutionalized geriatric schizophrenic patients. Am J Psychiatry. 152:1995;197-207.
    • (1995) Am J Psychiatry , vol.152 , pp. 197-207
    • Davidson, M.1    Harvey, P.D.2    Powchik, P.3
  • 8
    • 0028173472 scopus 로고
    • 31Phosphorus magnetic response spectroscopy of the frontal and parietal lobes in chronic schizophrenia
    • 31Phosphorus magnetic response spectroscopy of the frontal and parietal lobes in chronic schizophrenia. Biol Psychiatry. 36:1994;503-510.
    • (1994) Biol Psychiatry , vol.36 , pp. 503-510
    • Deicken, R.F.1    Calabrese, G.2    Merrin, E.L.3
  • 9
    • 0029036333 scopus 로고
    • Abnormal frontal lobe phosphorus metabolism in bipolar disorder
    • Deicken R.F., Fein G., Weiner M.W. Abnormal frontal lobe phosphorus metabolism in bipolar disorder. Am J Psychiatry. 152:1995;915-918.
    • (1995) Am J Psychiatry , vol.152 , pp. 915-918
    • Deicken, R.F.1    Fein, G.2    Weiner, M.W.3
  • 10
    • 0029781472 scopus 로고    scopus 로고
    • Inositol treatment of obsessive-compulsive disorder
    • Fux M., Levine J., Aviv A., Belmaker R.H. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry. 153:1996;1219-1221.
    • (1996) Am J Psychiatry , vol.153 , pp. 1219-1221
    • Fux, M.1    Levine, J.2    Aviv, A.3    Belmaker, R.H.4
  • 11
    • 0021740333 scopus 로고
    • Phosphorylethanolamine: The major constituent of the phosphomonoester peak observed by P-31 NMR of developing dog brain
    • Gyulai L., Bolinger L., Leigh J.S., Barlow C., Chance B. Phosphorylethanolamine The major constituent of the phosphomonoester peak observed by P-31 NMR of developing dog brain . FEBS Lett. 178:1984;137-142.
    • (1984) FEBS Lett , vol.178 , pp. 137-142
    • Gyulai, L.1    Bolinger, L.2    Leigh, J.S.3    Barlow, C.4    Chance, B.5
  • 12
    • 0021921539 scopus 로고
    • Patients dying after long terminal phase have acidotic brains: Implications for biochemical measurements on autopsy tissue
    • Hardy J.A., Wester P., Winblad B., Gezelius C., Bring G., Eriksson A. Patients dying after long terminal phase have acidotic brains Implications for biochemical measurements on autopsy tissue . J Neural Transm Gen Sect. 61:1985;253-264.
    • (1985) J Neural Transm Gen Sect , vol.61 , pp. 253-264
    • Hardy, J.A.1    Wester, P.2    Winblad, B.3    Gezelius, C.4    Bring, G.5    Eriksson, A.6
  • 13
    • 0029736547 scopus 로고    scopus 로고
    • Advances in post mortem molecular neurochemistry and neuropathology: Examples from schizophrenia research
    • Harrison P.J. Advances in post mortem molecular neurochemistry and neuropathology Examples from schizophrenia research . Br Med Bull. 52:1996;527-538.
    • (1996) Br Med Bull , vol.52 , pp. 527-538
    • Harrison, P.J.1
  • 14
    • 0028037077 scopus 로고
    • Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy
    • Haussinger D., Laubenberger J., Dahl V., et al. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology. 107:1994;1475-1480.
    • (1994) Gastroenterology , vol.107 , pp. 1475-1480
    • Haussinger, D.1    Laubenberger, J.2    Dahl, V.3
  • 16
    • 0025173203 scopus 로고
    • Increased forskolin binding in the left parahippocampal gyrus and CA1 region in post mortem schizophrenic brain determined by quantitative autoradiography
    • Kerwin R.W., Beats B.C. Increased forskolin binding in the left parahippocampal gyrus and CA1 region in post mortem schizophrenic brain determined by quantitative autoradiography. Neurosci Lett. 118:1990;164-168.
    • (1990) Neurosci Lett , vol.118 , pp. 164-168
    • Kerwin, R.W.1    Beats, B.C.2
  • 17
    • 0001403330 scopus 로고
    • 31P nuclear magnetic resonance (NMR) spectroscopy of the frontal lobe metabolism in neuroleptic naive first episode psychoses: Preliminary studies
    • 31P nuclear magnetic resonance (NMR) spectroscopy of the frontal lobe metabolism in neuroleptic naive first episode psychoses Preliminary studies . Schizophr Res. 2:1989;122.
    • (1989) Schizophr Res , vol.2 , pp. 122
    • Keshavan, M.S.1    Pettegrew, J.W.2    Panchalingam, K.3    Kaplan, D.4    Brar, J.5    Campbell, K.6
  • 18
    • 0028650388 scopus 로고
    • CSF inositol levels in schizophrenia are unchanged and inositol is not therapeutic in anergic schizophrenia
    • Levine J., Goldberger I., Rapaport A., et al. CSF inositol levels in schizophrenia are unchanged and inositol is not therapeutic in anergic schizophrenia. Eur Neuropsychopharmacol. 4:1994;487-490.
    • (1994) Eur Neuropsychopharmacol , vol.4 , pp. 487-490
    • Levine, J.1    Goldberger, I.2    Rapaport, A.3
  • 19
    • 0028904032 scopus 로고
    • A double-blind controlled trial of inositol treatment of depression
    • Levine J., Barak Y., Gonsalves M., et al. A double-blind controlled trial of inositol treatment of depression. Am J Psychiatry. 152:1995;792-794.
    • (1995) Am J Psychiatry , vol.152 , pp. 792-794
    • Levine, J.1    Barak, Y.2    Gonsalves, M.3
  • 20
    • 0027336369 scopus 로고
    • Increase in [3H] cAMP binding sites and decrease in Gi alpha and Go alpha immunoreactivities in left temporal cortices from patients with schizophrenia
    • Nishino N., Kitamura N., Hashimoto T., et al. Increase in [3H] cAMP binding sites and decrease in Gi alpha and Go alpha immunoreactivities in left temporal cortices from patients with schizophrenia. Brain Res. 615:1993;41-49.
    • (1993) Brain Res , vol.615 , pp. 41-49
    • Nishino, N.1    Kitamura, N.2    Hashimoto, T.3
  • 22
    • 0025070025 scopus 로고
    • G proteins (Gi, Go) and the basal ganglia of control and schizophrenic brain
    • Okada F., Crow T.J., Roberts G.W. G proteins (Gi, Go) and the basal ganglia of control and schizophrenic brain. J Neural Transm Gen Sect. 79:1990;227-234.
    • (1990) J Neural Transm Gen Sect , vol.79 , pp. 227-234
    • Okada, F.1    Crow, T.J.2    Roberts, G.W.3
  • 23
    • 84995059859 scopus 로고
    • Low amounts of the α-subunit of GTP-binding protein Go in orbital frontal cortex of schizophrenic brain: Biochemical evidence of the hypofrontality hypothesis of schizophrenia
    • Okada F., Tokumitsu T., Asano K., et al. Low amounts of the α-subunit of GTP-binding protein Go in orbital frontal cortex of schizophrenic brain Biochemical evidence of the hypofrontality hypothesis of schizophrenia . Schizophr Res. 4:1991;353-354.
    • (1991) Schizophr Res , vol.4 , pp. 353-354
    • Okada, F.1    Tokumitsu, T.2    Asano, K.3
  • 24
    • 0028174005 scopus 로고
    • Reduced concentrations of the alpha-subunit of GTP-binding protein Go in schizophrenic brain
    • Okada F., Tokumitsu Y., Takahashi N., Crow T.J., Roberts G.W. Reduced concentrations of the alpha-subunit of GTP-binding protein Go in schizophrenic brain. J Neural Transm Gen Sect. 95:1994;95-104.
    • (1994) J Neural Transm Gen Sect , vol.95 , pp. 95-104
    • Okada, F.1    Tokumitsu, Y.2    Takahashi, N.3    Crow, T.J.4    Roberts, G.W.5
  • 25
    • 0030610611 scopus 로고    scopus 로고
    • 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia
    • 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia. Biol Psychiatry. 42:1997;359-366.
    • (1997) Biol Psychiatry , vol.42 , pp. 359-366
    • Omori, M.1    Pearce, J.2    Komoroski, R.A.3
  • 26
    • 0023784340 scopus 로고
    • Are post-mortem biochemical studies of human brain worthwhile?
    • Palmer A.M., Lowe S.L., Francis P.T., Bowen D.M. Are post-mortem biochemical studies of human brain worthwhile? Biochem Soc Trans. 16:1988;472-475.
    • (1988) Biochem Soc Trans , vol.16 , pp. 472-475
    • Palmer, A.M.1    Lowe, S.L.2    Francis, P.T.3    Bowen, D.M.4
  • 27
    • 0030273350 scopus 로고    scopus 로고
    • Effect of age, sex, steroids, brain region and genetic strain on brain inositol monophosphatase activity
    • Patishi Y., Belmaker R.H., Agam G. Effect of age, sex, steroids, brain region and genetic strain on brain inositol monophosphatase activity. Biol Psychiatry. 40:1996;656-659.
    • (1996) Biol Psychiatry , vol.40 , pp. 656-659
    • Patishi, Y.1    Belmaker, R.H.2    Agam, G.3
  • 28
    • 0025769846 scopus 로고
    • Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics
    • Pettegrew J.W., Keshavan M., Panchalingam K., et al. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. Arch Gen Psychiatry. 48:1991;563-568.
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 563-568
    • Pettegrew, J.W.1    Keshavan, M.2    Panchalingam, K.3
  • 29
    • 0026471211 scopus 로고
    • Lithium-induced modulation of cerebral inositol phosphate metabolism in the rat: A multinuclear magnetic resonance study in vivo
    • Preece N.E., Gadian D.G., Houseman J., Williams S.R. Lithium-induced modulation of cerebral inositol phosphate metabolism in the rat A multinuclear magnetic resonance study in vivo . Lithium. 3:1992;287-297.
    • (1992) Lithium , vol.3 , pp. 287-297
    • Preece, N.E.1    Gadian, D.G.2    Houseman, J.3    Williams, S.R.4
  • 30
    • 0027417568 scopus 로고
    • Severe cognitive impairments in elderly schizophrenic patients: A clinicopathological study
    • Purohit D.P., Davidson M., Perl D.P., et al. Severe cognitive impairments in elderly schizophrenic patients A clinicopathological study . Biol Psychiatry. 33:1993;255-260.
    • (1993) Biol Psychiatry , vol.33 , pp. 255-260
    • Purohit, D.P.1    Davidson, M.2    Perl, D.P.3
  • 32
    • 0019831422 scopus 로고
    • Evidence that lithium alters phosphoinositide metabolism: Chronic administration elevates primarily D-myo-inositol-1-phosphate in cerbral cortex of the rat
    • Sherman W.R., Leavitt A.L., Honchar M.P., Hallcher L.M., Phillips B.E. Evidence that lithium alters phosphoinositide metabolism Chronic administration elevates primarily D-myo-inositol-1-phosphate in cerbral cortex of the rat . J Neurochem. 36:1981;1947-1951.
    • (1981) J Neurochem , vol.36 , pp. 1947-1951
    • Sherman, W.R.1    Leavitt, A.L.2    Honchar, M.P.3    Hallcher, L.M.4    Phillips, B.E.5
  • 33
    • 0030877331 scopus 로고    scopus 로고
    • Reduced inositol levels in frontal cortex of post-mortem brain from bipolar patients and suicides
    • Shimon H., Agam G., Belmaker R.H., Hyde T., Kleinman J.E. Reduced inositol levels in frontal cortex of post-mortem brain from bipolar patients and suicides. Am J Psychiatry. 154:1997;1148-1150.
    • (1997) Am J Psychiatry , vol.154 , pp. 1148-1150
    • Shimon, H.1    Agam, G.2    Belmaker, R.H.3    Hyde, T.4    Kleinman, J.E.5
  • 34
    • 0025911775 scopus 로고
    • Localized phosphorous 31 magnetic resonance spectroscopy in chronic schizophrenic patients and normal controls [letter]
    • Williamson P., Drost D., Stanley J., Carr T., Morrison S., Merskey H. Localized phosphorous 31 magnetic resonance spectroscopy in chronic schizophrenic patients and normal controls [letter]. Arch Gen Psychiatry. 48:1991;578.
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 578
    • Williamson, P.1    Drost, D.2    Stanley, J.3    Carr, T.4    Morrison, S.5    Merskey, H.6
  • 35
    • 0025062555 scopus 로고
    • Progressive ventricular enlargement in schizophrenia: Comparison to bipolar affective disorder and correlation with clinical course
    • Woods B.T., Yurgelun-Todd D., Benes F.M., Frankenburg F.R., Pope H.G. Jr, McSparren J. Progressive ventricular enlargement in schizophrenia Comparison to bipolar affective disorder and correlation with clinical course . Biol Psychiatry. 27:1990;341-352.
    • (1990) Biol Psychiatry , vol.27 , pp. 341-352
    • Woods, B.T.1    Yurgelun-Todd, D.2    Benes, F.M.3    Frankenburg, F.R.4    Pope H.G., Jr.5    McSparren, J.6


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