Microemulsions as colloidal vehicle systems for dermal drug delivery. Part V: Microemulsions without and with glycolipid as penetration enhancer

Journal of Pharmaceutical Sciences

Volumn 94, Issue 4, 2005, Pages 821-827

  Neubert, Reinhard H H ^a   Schmalfuß, Ulrike ^a   Wolf, Raik ^a,b   Wohlrab, Wolfgang A ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b PROBIODRUG AG   (Germany)

Author keywords

Colloidal vehicle systems (microemulsions); Drug localizer effect; Glycolipid, penetration modifier; Human skin ex vivo

Indexed keywords

DIPHENHYDRAMINE; GLUCOPYRANOSIDE; GLYCOLIPID; PALMITIC ACID ISOPROPYL ESTER; PENETRATION ENHANCING AGENT; POLYSORBATE 80; SORBITAN LAURATE;

AQUEOUS SOLUTION; ARTICLE; COLLOID; DERMIS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; EPIDERMIS; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROGEL; HYDROPHILICITY; IN VITRO STUDY; MASS SPECTROMETRY; MEASUREMENT; MICROEMULSION; MODEL; SKIN PENETRATION;

EID: 17744386772     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20233     Document Type: Article

References (26)

1. Ternjala S. 1999. Microemulsions: An overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst 16:461-521.
2. Jahn K, Krause A, Janich M, Neubert RHH. 2002. Colloidal drug carrier systems. In: Bronaugh RL, Maibach HI, editors. Topical absorption of dermatological products. New York: Marcel Dekker, Inc.
3. Lehmann L, Keipert S, Gloor M. 2001. Effects of microemulsions on the stratum corneum and hydrocortison penetration. Eur J Pharm Biopharm 52: 129-136.
4. von Rybinski W, Guckembiel B, Tesmann H. 1998. Influence of co-surfactants on microemulsions with alkyl polyglycosides. Colloids Surf A 142:333-342.
5. Kreilgaard M, Kremme MJB, Burggraaf J, Schoemaker RC, Cohen AF. 2001. Influence of microemulsion vehicle on cutaneous bioequivalence of a lipohilic model drug assesed by microdialysis and pharmacodynamics. Pharm Res 18:593-599.
6. Alvarez-Figueroa MJ, Blanco-Mendez J. 2001. Transdermal delivery of methotrexate: Iontophoretic delivery from hydrogels and passive delivery from microemulsions. Int J Pharm 215:57-65.
7. Kreilgaard M. 2001. Dermal pharmacokinetics of microemulsion formulations determined by in vivo microdialysis. Pharm Res 18:367-373.
8. Kreilgaard M, Pedersen EJ, Jarozewski JW. 2000. NMR characterisation and transdermal drug delivery potential of microemulsion systems. J Controlled Release 69:421-433.
9. Paolino D, Ventura CA, Nistico S, Pugilsi G, Fresta M. 2002. Lecthin micro-emulsions for topical administration of ketoprofen: Percutaneous absorption through human skin and in vivo humen tolerability. Int J Pharm 244:21-31.
10. Trotta M, Pattarino F, Grosa G. 1998. Formation of lecithin-based microemulsions containing n-alkanol phosphocholines. Int J Pharm 174:253-259.
11. Park K-M, Lee M-K, Hwang K-J, Kim C-K. 1999. Phospholipid-based microemulsions of flurbiprofen by the spontaneous emusification process. Int J Pharm 183:145-154.
12. Peira E, Scolari P, Gasco MR. 2001. Transdermal permeation of apomorphine through hairless mouse skin from microemulsions. Int J Pharm 226:47-51.
13. Bolzinger MA, Thevenin MA, Carduner C, Poelman MC. 1998. Bicontinuous sucrose ester microemulsion: A new vehicle for topical delivery of niflumic acid. Int J Pharm 176:39-45.
14. Dalmora MEA, Oliviera AG. 1999. Inclusion complex of piroxicam with β-cyclodextrin and incorporation in hexadecyltrimethyammonium bromide based microemulsion. Int J Pharm 184:157-164.
15. Dalmora MEA, Dalmora SL, Oliviera AG. 2001. Inclusion complex of piroxicam with cyclödextrin and incorporation in cationic microemulsion. In vitro drug release and in vivo topical anti-inflammatory effect. Int J Pharm 222:45-55.
16. Alany RG, Tucker IG, Davis NM, Rades T. 2001. Chracterizing colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphilic systems. Drug Dev Ind Pharm 27:31-38.
17. Lee PJ, Langer R, Shastri VP. 2003. Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs. Pharm Res 20:264-269.
18. Trotta M, Morel S, Gasco MR. 1997. Effect of oil phase composition on the skin permeation of felodipine from o/w microemulsions. Pharmazie 52:51-53.
19. Shukla A, Krause A, Neubert RHH. 2003. Microemulsions as colloidal vehicle systems for dermal drug delivery. Part IV: Investigation of microemulsion systems based on a eutectic mixture of lidocain and prilocains as colloidal phase by dynamic light scattering. J Pharm Pharmacol 55:741-748.
20. Shukla A, Janich M, Jahn K, Krause A, Kiselev MA, Neubert RHH. 2002. Investigations of pharmaceutical oil/water microemulsions by small-angle scattering. Pharm Res 18:881-886.
21. Shukla A, Janich M, Jahn K, Neubert RHH. 2003. Microemulsions for dermal delivery studied by dynamic light scattering: Effect of interparticle interaction in oil-in-water microemulsions. J Pharm Sci 92:730-738.
22. Rhee Y-S, Choi J-G, Park E-S, Chi S-C. 2001. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm 228:161-170.
23. Wilhelm F, Chatterjee SK, Rattay B, Nuhn P, Benecke R, Ortwein J. 1995. Synthesis of glycolipids as membrane-bound stabilizing carbohydrates. Liebigs Ann 1995:1673-1679.
24. Neubert RHH, Bendas C, Wohlrab W, Gienau B, Fürst W. 1991. A multilayer membrane system for modelling drug penetration into skin. Int J Pharm 75:89-94.
25. Schneider I-M. 1997. Untersuchungen zum Einfluss von Glycolipiden und Fettsäuren auf den Wirkstofftransport in humane Haut und das Proliferationsverhalten von humanen Keratinozyten. PhD Thesis, Martin-Luther-University, Halle-Wittenberg.
26. Mrestani Y, Neubert R. 2000. Characterization of cephalosporin transfer between aqueous and colloidal phases by micellar electrokinetic chromatography. J Chromatogr A 871:439-448.